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Categories: Biology: Molecular, Mathematics: Puzzles
Published Octopuses rewire their brains to adapt to seasonal temperature shifts



Octopuses don't thermoregulate, so their powerful brains are exposed to -- and potentially threatened by -- changes in temperature. Researchers report that two-spot octopuses adapt to seasonal temperature shifts by producing different neural proteins under warm versus cool conditions. The octopuses achieve this by editing their RNA, the messenger molecule between DNA and proteins. This rewiring likely protects their brains, and the researchers suspect that this unusual strategy is used widely amongst octopuses and squid.
Published A compound from fruit flies could lead to new antibiotics



Research shows that the natural peptide, called drosocin, protects fruit flies from bacterial infections by binding to ribosomes in bacteria. Once bound, drosocin prevents the ribosome from making new proteins.
Published Muscle fibers: An unexpected organization revealed



Researchers have just made the unexpected discovery of a novel organization of muscle fibers in Parophidion vassali, a fish that lives in the Mediterranean Sea and, like many fish, uses specialized muscles to produce sounds. This is an important discovery that could well change our understanding of muscle contraction.
Published New class of antibiotics to fight resistant bacteria



Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.
Published Symbiotic and pathogenic fungi may use similar molecular tools to manipulate plants



Symbiotic and pathogenic fungi that interact with plants are distantly related and don't share many genetic similarities. Comparing plant pathogenic fungi and plant symbiotic fungi, scientists at the Sainsbury Laboratory Cambridge University (SLCU) have discovered that these remote relatives are using a similar group of proteins to manipulate and live within plants.
Published DNA damage repaired by antioxidant enzymes



In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.
Published Engineers report low-cost human biomarker sensor designs



Researchers have developed a low-cost, RNA-based technology to detect and measure biomarkers, which can help decode the body's physiology. The presence of protein biomarkers can indicate chronic or acute conditions, from arthritis to cancer to bacterial infections, for which conventional tests can cost anywhere from $100 to upwards of $1,000. The new technology can perform the same measurement for about a dollar.
Published A protein mines, sorts rare earths better than humans, paving way for green tech



Rare earth elements, like neodymium and dysprosium, are a critical component to almost all modern technologies, from smartphones to hard drives, but they are notoriously hard to separate from the Earth's crust and from one another. Scientists have discovered a new mechanism by which bacteria can select between different rare earth elements, using the ability of a bacterial protein to bind to another unit of itself, or 'dimerize,' when it is bound to certain rare earths, but prefer to remain a single unit, or 'monomer,' when bound to others.
Published Phenomenal phytoplankton: Scientists uncover cellular process behind oxygen production



According to new research, the amount of oxygen in one of 10 breaths was made possible thanks to a newly identified cellular mechanism that promotes photosynthesis in marine phytoplankton. The new study identifies how a proton pumping enzyme (known as VHA) aids in global oxygen production and carbon fixation from phytoplankton.
Published How the flu virus hacks our cells



Influenza epidemics, caused by influenza A or B viruses, result in acute respiratory infection. They kill half a million people worldwide every year. These viruses can also wreak havoc on animals, as in the case of avian flu. A team has now identified how the influenza A virus manages to penetrate cells to infect them. By attaching itself to a receptor on the cell surface, it hijacks the iron transport mechanism to start its infection cycle. By blocking the receptor involved, the researchers were also able to significantly reduce its ability to invade cells. These results highlight a vulnerability that could be exploited to combat the virus.
Published Eat right, live longer: Could a moderate protein diet be the coveted elixir of youth?



Consuming nutritious food can improve metabolic health and delay aging. But what are the appropriate quantities of dietary macronutrients that can help achieve this? To answer this, researchers fed isocaloric diets with varying amounts of protein to young and middle-aged male mice. They found that the mice were metabolically healthier when fed moderate-protein diets. These findings could provide valuable insights into developing nutritional interventions and improving metabolic health in people.
Published Researchers use 'natural' system to identify proteins most useful for developing an effective HIV vaccine



Scientists have spent years trying to develop an effective HIV vaccine, but none have proven successful. Based on findings from a recently published study, a research team may have put science one step closer to that goal.
Published Light conveyed by the signal transmitting molecule sucrose controls growth of plant roots



Researchers shows how information about the quantity of absorbed light passes from the leaves to the roots. Photosynthetic sucrose not only supplies roots with carbohydrates but also acts as a signal transmitter for light-dependent root architecture.
Published Scientists unveil RNA-guided mechanisms driving cell fate



The early stages of embryonic development contain many of life's mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new regenerative medicine treatments. Researchers have now characterized a critical time in mammalian embryonic development using powerful and innovative imaging techniques.
Published Protein-based nano-'computer' evolves in ability to influence cell behavior



The first protein-based nano-computing agent that functions as a circuit has been created. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer.
Published Researchers successfully induce primate oocytes in the lab



The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. Currently, it is challenging for researchers to control the differentiation of stem cells in the lab (in vitro). Of particular interest are oocytes, which are female germ cells that develop into eggs. Understanding their development could have far-ranging impacts, from infertility treatment to conservation of endangered species. A new study has successfully induced meiotic (dividing) oocytes from the embryonic stem cells of cynomolgus monkeys, which share many physiological traits with humans. By establishing a culture method for inducing the differentiation of meiotic oocytes, the researchers aimed to shed light on germ cell development in both humans and other primates.
Published The fast and the fibrous: Developing the muscles you need for speed



Researchers have identified the role of the large Maf transcription factor family in regulating fast twitch muscle fibers. A mouse model lacking Maf expression in the skeletal muscles exhibited a significant loss of type IIb myofibers, a subtype of fast twitch fibers. Overexpression of large Mafs promoted type IIb muscle fiber induction. The large Maf family may represent potential targets for developing treatments for muscular disorders involving fast twitch fibers.
Published How tasty is the food?



A hormone and specialized brain cells regulate feeding behavior in mice.
Published Where do our limbs come from?



Scientists have uncovered new clues about the origin of paired appendages -- a major evolutionary step that remains unresolved and highly debated.
Published A look into the heart of cellular waste disposal



Researchers reveal how a nanomachine takes care of cleaning up inside the cell.