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Categories: Biology: Molecular, Mathematics: General

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A new analysis sheds light on the molecular processes involved when a carnivorous species of fungus known as Arthrobotrys oligospora senses, traps and consumes a worm.

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A team of researchers found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.

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Biological materials are made of individual components, including tiny motors that convert fuel into motion. This creates patterns of movement, and the material shapes itself with coherent flows by constant consumption of energy. Such continuously driven materials are called 'active matter'. The mechanics of cells and tissues can be described by active matter theory, a scientific framework to understand shape, flows, and form of living materials. The active matter theory consists of many challenging mathematical equations. Scientists have now developed an algorithm, implemented in an open-source supercomputer code, that can for the first time solve the equations of active matter theory in realistic scenarios. These solutions bring us a big step closer to solving the century-old riddle of how cells and tissues attain their shape and to designing artificial biological machines.

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Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers now report.

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CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions.   While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis.

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Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.

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A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation.  Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.

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Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.

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Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.

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A team of researchers looked back at a model that predicted nuclear power would expand dramatically in order to assess the efficacy of energy policies implemented today.

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Bacteria have an array of strategies to counter viral invasion, but how they first spot a stranger in their midst has long been a mystery.

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Researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage.

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Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles. 

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Rhomboid-like protein 10, or RBL10, is thought to be an enzyme that degrades other proteins in the chloroplast membrane, but its function is largely unknown. Researchers are studying how RBL10 affects photosynthetic membrane lipid metabolism, an essential process in photosynthesis.

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An international research team has made an unexpected discovery of a biased counting mechanism used by the single-celled green alga Chlamydomonas to control cell division. 

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A research team has presented its findings on the functioning of an atypical cryptochrome protein (Cry). These proteins are found in a variety of organisms, and they are often involved in light-controlled biological processes. The marine bristle worm Platynereis dumerilii, for example, employs a special Cry protein designated L-Cry to distinguish between sunlight and moonlight as well as between different moon phases. This is essential for the worms to synchronize their reproduction to the full moon phase via an inner monthly calendar, also called circalunar clock.

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Researchers have discovered the mechanism by which cholesterol in our diet is absorbed into our cells. This discovery opens up new opportunities for therapeutic intervention to control cholesterol uptake that could complement other therapies and potentially save lives.

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Researchers are working to understand how protein quality control works in cells. 

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Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.  Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells.

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Biologists have discovered a phosphorus-based bacterial metabolism that is both new and ancient. In a special role: a calculation from the 1980s, a sewage plant, a new bacterial organism, and a remnant from around 2.5 billion years ago.