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Categories: Biology: Molecular, Mathematics: General
Published Loops, flags and tension in DNA
(via sciencedaily.com) Original source Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei. DNA tension plays a surprising role in this. Nanoscientists now publish how they have visualized this.
Published New mechanism for DNA folding
(via sciencedaily.com) Original source A hitherto unknown mechanism for DNA folding is described in a new study. The findings provide new insights into chromosomal processes that are vital to both normal development and to prevent disease.
Published Rock, paper, scissors: Searching for stronger nonlocality using quantum computers
(via sciencedaily.com) Original source In the quantum world particles can instantaneously know about each other's state, even when separated by large distances. This is known as nonlocality. Now, A research group has produced some interesting findings on the Hardy nonlocality that have important ramifications for understanding quantum mechanics and its potential applications in communications.
Published Novel nanocages for delivery of small interfering RNAs
(via sciencedaily.com) Original source Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases. This has led to a growing demand for selective, efficient, and safe ways of delivering siRNA in cells. Now, in a cooperation between the Universities of Amsterdam and Leiden, researchers have developed dedicated molecular nanocages for siRNA delivery. In a paper just out in the Journal Chem they present nanocages that are easy to prepare and display tuneable siRNA delivery characteristics.
Published SpyLigation uses light to switch on proteins
(via sciencedaily.com) Original source Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail. This technology has potential uses in tissue engineering, regenerative medicine, and understanding how the body works. The scientists applied their new method to control the glow of a green fluorescent protein derived from Japanese eel muscle.
Published Molecular 'Superpower' of antibiotic-resistant bacteria
(via sciencedaily.com) Original source A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study now shows how two molecular mechanisms can work together make the bacterium extra resistant.
Published Tracking a new path to octopus and squid sensing capabilities
(via sciencedaily.com) Original source Research has traced the evolutionary adaptations of octopus and squid sensing capabilities. The researchers describe for the first time the structure of an octopus chemotactile receptor, which octopus arms use for taste-by-touch exploration of the seafloor.
Published How a virus causes chromosomal breakage, leading to cancer
(via sciencedaily.com) Original source Researchers describe how the Epstein-Barr virus exploits genomic weaknesses to cause cancer while reducing the body's ability to suppress it.
Published Where did the first sugars come from?
(via sciencedaily.com) Original source Origin-of-life chemists propose that glyoxylate could have been the original source of sugars on the 'prebiotic' Earth
Published Biologists determine the evolutionary age of individual cell types providing critical insights for animal development
(via sciencedaily.com) Original source A research team has recently made a significant discovery about the evolutionary age of different type of cells in a small animal called Caenorhabditis elegans (C. elegans). By using single-cell transcriptomic data and refined phylostratigraphy, the team determines the transcriptomic age of individual cells, which means they are able to estimate the evolutionary origin of different cells based on the age of the genes expressed in the cells.
Published Study compares de novo proteins with randomly produced proteins
(via sciencedaily.com) Original source In a series of experiments, a team of researchers have compared de novo proteins with random-sequence proteins, looking at their stability and solubility. The results are set to advance basic research in this new field.
Published Oral barrier is similar in ceramide composition to skin barrier
(via sciencedaily.com) Original source Acylceramides and protein-bound ceramides are vital for the formation of the oral barrier in mice, similar to their role in skin, protecting from infection.
Published Genes are read faster and more sloppily in old age
(via sciencedaily.com) Original source Scientists have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers. With dietary restrictions, these processes could be reversed.
Published Male yellow crazy ants are real-life chimeras
(via sciencedaily.com) Original source Researchers discovered that males of the yellow crazy ant have maternal and paternal genomes in different cells of their body and are thus chimeras.
Published Here's how a worm's embryonic cells changed its development potential
(via sciencedaily.com) Original source Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.
Published Researchers clear the way for well-rounded view of cellular defects
(via sciencedaily.com) Original source New research investigates how cells divide, particularly in the fibrous environment of living tissue. Cells are typically studied in a flat environment, and the difference between flat and fibrous landscapes opens new windows into the behavior of cells and the diseases that impact them.
Published Broccoli consumption protects gut lining, reduces disease, in mice
(via sciencedaily.com) Original source Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidence of cancer and type 2 diabetes. In a recent study, researchers found that broccoli contains certain molecules that bind to a receptor within mice and help to protect the lining of the small intestine, thereby inhibiting the development of disease. The findings lend support to the idea that broccoli truly is a 'superfood.'
Published Blind dating in bacteria evolution
(via sciencedaily.com) Original source A team of researchers reconstructed long-extinct proteins of a UV protection system of cyanobacteria. The surprising result: the proteins were already compatible with each other when they first met. This discovery expands the knowledge horizon on the rules of evolution.
Published Researchers create embryo-like structures from monkey embryonic stem cells
(via sciencedaily.com) Original source Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study. Investigators now report on the creation of embryo-like structures from monkey embryonic stem cells. The investigators also transferred these embryo-like structures into the uteruses of female monkeys and determined that the structures were able to implant and elicit a hormonal response similar to pregnancy.
Published Activating adult-born neurons through deep brain stimulation alleviates Alzheimer's symptoms in rodent models
(via sciencedaily.com) Original source People with Alzheimer's disease develop defects in cognitive functions like memory as well as problems with noncognitive functions that can lead to anxiety and depression. Investigators used mice to study a process through which new neurons are generated in adulthood, called adult hippocampus neurogenesis (AHN). The research showed that deep brain stimulation of new neurons helped restore both cognitive and noncognitive functions in mouse models of Alzheimer's disease.