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Categories: Biology: Molecular, Mathematics: Statistics
Published Vitamin B12 adaptability in Antarctic algae has implications for climate change, life in the Southern Ocean
(via sciencedaily.com) Original source The algae P. antarctica has two forms of the enzyme that makes the amino acid methionine, one needing B12, and one that is slower, but doesn't need it. This means it has the ability to adapt and survive with low B12 availability. The presence of the MetE gene in P. antarctica gives the algae the ability to adapt to lower vitamin B12 availability, giving it a potential advantage to bloom in the early austral spring when bacterial production is low. P. antarctica takes in the CO2 and releases oxygen through photosynthesis. Understanding its ability to grow in environments with low vitamin B12 availability can help climate modelers make more accurate predictions.
Published Scientists see an ultra-fast movement on surface of HIV virus
(via sciencedaily.com) Original source Seeing a glycoprotein on the envelope of the HIV virus snap open and shut in mere millionths of a second is giving investigators a new handle on the surface of the virus that could lead to broadly neutralizing antibodies for an AIDS vaccine. Being able to attach an antibody specifically to this little structure that would prevent it from popping open would be key.
Published Mechanism discovered that protects tissue after faulty gene expression
(via sciencedaily.com) Original source A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.
Published Disrupted cellular function behind type 2 diabetes in obesity
(via sciencedaily.com) Original source Disrupted function of 'cleaning cells' in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not. A study describes this newly discovered mechanism.
Published A clutch stretch goes a long way
(via sciencedaily.com) Original source New results reveal a new mode of force transmission in which dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. This discovery underscores the necessity of molecular elasticity and random coupling for sufficiently transmitting force. The findings also call for revising the role of molecular unfolding.
Published Plant receptors that control immunity and development share a common origin
(via sciencedaily.com) Original source Researchers have traced the origin and evolutionary trajectory of plant immune receptors. Their discovery will make it easier to identify immune receptor genes from genomic information and could help in the development of pathogen-resistant crops.
Published Gut bacteria can process dietary fiber into an anti-allergy weapon
(via sciencedaily.com) Original source Short-chain fatty acids (SCFAs), which are produced by gut bacteria from dietary fiber, regulate our immune system, but the mechanism of their action remains unknown. In a recent study, researchers investigated how SCFAs interact with mast cells, a type of white blood cell that plays a central role in allergic reactions. Their findings and insights could lead to innovative and effective anti-allergy medications, supplements, and diets, paving the way for healthier lives.
Published Shining a new light on the tug-of-war between virus and host
(via sciencedaily.com) Original source The interplay between ribonucleic acid (RNA) and proteins is not only important for maintaining cellular homeostasis but is also at the center of the tug-of-war between virus and host. Until now, there has been no method to globally map direct interactions of individual RNA regions in an unbiased fashion without the need for genetic modification of the target RNA or cell. Researchers have now developed a breakthrough tool that overcomes this limitation.
Published How seahorse-like toxins kill insects
(via sciencedaily.com) Original source Insect-killing bacteria typically release toxins to slay their hosts. The bacterium Photorhabdus luminescens, for example, pumps insect larvae full of the lethal 'Makes caterpillars floppy 1' (Mcf1) toxin, leading them to first become droopy and then dead. However, it has so far been a mystery how Mcf1 unfolds its devastating effect. Researchers successfully used cryo-electron microscopy (cryo-EM) and biochemical assays to characterize the first-ever Mcf1 structure, allowing them to propose a molecular mechanism of the toxin's action. Understanding how bacterial toxins perform their deadly task in such detail is very useful for engineering novel biopesticides, thereby reducing the use of barely specific chemical agents with harmful side effects for the ecosystem.
Published Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells
(via sciencedaily.com) Original source New research demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
Published DNA particles that mimic viruses hold promise as vaccines
(via sciencedaily.com) Original source Using a DNA-based delivery particle, researchers created a vaccine that can induce a strong antibody response against SARS-CoV-2.
Published Asparagus and orchids are more similar than you think
(via sciencedaily.com) Original source How is a beech leaf constructed? What determines the appearance of an asparagus? A new 'encyclopaedia' helps us learn more about the building blocks of plants. The encyclopaedia, probably the largest of its kind, could be used to improve targeted plant breeding efforts, to make them both more climate-resilient and more easily digestible.
Published 'Genomic time machine' reveals secrets of our DNA
(via sciencedaily.com) Original source Researchers reveal a novel method to uncover bits of our genetic blueprint that come from ancient genetic parasites, offering fresh insights into human evolution and health.
Published A non-allergenic wheat protein for growing better cultivated meat
(via sciencedaily.com) Original source As the world's population increases, cultivated or lab-grown meat -- animal muscle and fat cells grown in laboratory conditions -- has emerged as a potential way to satisfy future protein needs. And edible, inexpensive plant proteins could be used to grow these cell cultures. Now, researchers report that the non-allergenic wheat protein glutenin successfully grew striated muscle layers and flat fat layers, which could be combined to produce meat-like textures.
Published How obesity dismantles our mitochondria
(via sciencedaily.com) Original source Researchers found that when mice were fed a high-fat diet, mitochondria within their fat cells broke apart and were less able to burn fat, leading to weight gain. They also found they could reverse the effect by targeting a single gene, suggesting a new treatment strategy for obesity.
Published Soap bark discovery offers a sustainability booster for the global vaccine market
(via sciencedaily.com) Original source A valuable molecule sourced from the soapbark tree and used as a key ingredient in vaccines, has been replicated in an alternative plant host for the first time, opening unprecedented opportunities for the vaccine industry.
Published How HIV smuggles its genetic material into the cell nucleus
(via sciencedaily.com) Original source Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year. To replicate and spread the infection, the virus must smuggle its genetic material into the cell nucleus and integrate it into a chromosome. Research teams have now discovered that its capsid has evolved into a molecular transporter. As such, it can directly breach a crucial barrier, which normally protects the cell nucleus against viral invaders. This way of smuggling keeps the viral genome invisible to anti-viral sensors in the cytoplasm.
Published How macrophages regulate regenerative healing in spiny mice
(via sciencedaily.com) Original source A team of researchers is delving deeper into the science behind how spiny mice can regenerate lost tissue and using what they learn to trigger regeneration in other types of mice -- advances which one day may be translated into humans. Whereas adult laboratory mice heal injuries with scar tissue, spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.
Published Cellular scaffolding rewired to make microscopic railways
(via sciencedaily.com) Original source Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.
Published The underground network: Decoding the dynamics of plant-fungal symbiosis
(via sciencedaily.com) Original source The intricate dance of nature often unfolds in mysterious ways, hidden from the naked eye. At the heart of this enigmatic tango lies a vital partnership: the symbiosis between plants and a type of fungi known as arbuscular mycorrhizal (AM) fungi. New groundbreaking research delves into this partnership, revealing key insights that deepen our understanding of plant-AM fungi interactions and could lead to advances in sustainable agriculture.