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Categories: Biology: Molecular, Mathematics: Statistics
Published Simulations show how HIV sneaks into the nucleus of the cell
(via sciencedaily.com) Original source A new study has revealed how HIV squirms its way into the nucleus as it invades a cell.
Published Researchers pinpoint most likely source of HIV rebound infection
(via sciencedaily.com) Original source Antiretroviral therapy (ART) does an excellent job at suppressing HIV to undetectable levels in the blood. However, small amounts of latent virus hide throughout the body, and when treatment is stopped, it opens the door for the virus to rebound. Researchers identified which tissues SIV, the nonhuman primate version of HIV, reemerges from first, just seven days after ART is stopped.
Published How does HIV get into the cell's cenetr to kickstart infection?
(via sciencedaily.com) Original source UNSW Sydney medical scientists have cracked a mystery whose solution has long eluded researchers. UNSW Sydney medical scientists have cracked a mystery whose solution has long eluded researchers.
Published Research of water droplet interfaces that offer the secret ingredient for building life
(via sciencedaily.com) Original source Scientists have experimental evidence that the key step in protein formation can occur in droplets of pure water.
Published New tool reveals gene behavior in bacteria
(via sciencedaily.com) Original source Researchers showed that the way in which genes are turned on and off as bacteria grow provide clues to their regulation.
Published New study unveils how plants control the production of reactive oxygen species
(via sciencedaily.com) Original source Reactive oxygen species (ROS), though generally regarded as toxic byproducts of biological processes, serve many important functions in plants. However, the precise mechanism that plants use to regulate the production of ROS remains elusive. In a recent study, researchers clarified how an important ROS-generating enzyme is activated, revealing mechanisms likely conserved across all land plants. Their findings could pave the way for breakthroughs in agricultural and environmental remediation tools.
Published Health researchers develop software to predict diseases
(via sciencedaily.com) Original source IntelliGenes analyzes genomic data to discover biomarkers associated with health traits.
Published Tiny worm, giant leap: Discovery of highly specific fatty acid attachment to proteins
(via sciencedaily.com) Original source In a world where the intricacies of molecular biology often seem as vast and mysterious as the cosmos, a new groundbreaking study delves into the microscopic universe of proteins, unveiling a fascinating aspect of their existence. This revelation could hold profound implications for the understanding and treatment of a myriad of human diseases.
Published Don't overeat: How archaea toggle the nitrogen-uptake switch
(via sciencedaily.com) Original source By tightly regulating nitrogen uptake, microorganisms avoid overeating nitrogen and thus wasting energy. Scientists now reveal how some methanogenic archaea manage to do so.
Published Single-celled kamikazes spearhead bacterial infection
(via sciencedaily.com) Original source You suddenly feel sick -- pathogenic bacteria have managed to colonize and spread in your body! The weapons they use for their invasion are harmful toxins that target the host's defense mechanisms and vital cell functions. Before these deadly toxins can attack host cells, bacteria must first export them from their production site -- the cytoplasm -- using dedicated secretion systems.
Published DNA construction led to unexpected discovery of important cell function
(via sciencedaily.com) Original source Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signalling pathway works and how it is involved in several serious diseases.
Published New technique visualizes mechanical structure of the cell nucleus
(via sciencedaily.com) Original source The cell nucleus is considered to be the control center of vital cellular processes, but its material properties continue to puzzle scientists. An international research team has now developed a new technique that provides a previously unattainable view of the mechanical properties inside this control center. For the first time, it has been possible to visualize over time its peculiar dynamic structural features in living cells, which appear to be crucial for cell function.
Published Nearly dead plants brought back to life: Keys to aging hidden in the leaves
(via sciencedaily.com) Original source Scientists have known about a particular organelle in plant cells for over a century. However, scientists have only now discovered that organelle's key role in aging.
Published Study throws our understanding of gene regulation for a loop
(via sciencedaily.com) Original source To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops can help repress or silence gene activity, with potentially far-reaching effects on human health.
Published Machine learning reveals sources of heterogeneity among cells in our bodies
(via sciencedaily.com) Original source A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria.
Published Glowing COVID-19 diagnostic test prototype produces results in one minute
(via sciencedaily.com) Original source Cold, flu and COVID-19 season brings that now-familiar ritual: swab, wait, look at the result. But what if, instead of taking 15 minutes or more, a test could quickly determine whether you have COVID-19 with a glowing chemical? In a new study, researchers describe a potential COVID-19 test inspired by bioluminescence. Using a molecule found in crustaceans, they have developed a rapid approach that detects SARS-CoV-2 protein comparably to one used in vaccine research.
Published Unraveling the role of supersulfides in regulating mitochondrial function and longevity
(via sciencedaily.com) Original source Supersulfides, many of which are produced by cysteinyl-tRNA synthetase (CARS), are essential compounds across many different lifeforms. However, the precise physiological roles of CARS-produced supersulfide are unclear. Now, using a strategically engineered yeast mutant with a deficient CARS gene, researchers from Japan have shown that supersulfides control cell longevity by mediating mitochondrial energy metabolism and regulating protein quality.
Published Bioinformatics: Researchers develop a new machine learning approach
(via sciencedaily.com) Original source To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.
Published A novel pathway regulating lipid biosynthesis by fatty acids
(via sciencedaily.com) Original source Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid biosynthesis. Moreover, the team unveiled, for the first time, that the biosynthesis process of fatty acid in the liver is activated by saturated fatty acids and inhibited by polyunsaturated fatty acids, providing new insights into the intricate workings of this cleavage system.
Published New insights into what helps Salmonella cause infections
(via sciencedaily.com) Original source In a new study, researchers have discovered how a system of proteins, called TamAB, helps Salmonella survive under the harsh conditions inside macrophages.