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Categories: Biology: Molecular, Mathematics: Statistics

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Dendritic cells are immune cells that capture and present antigens to T cells, activating an immune response. Researchers have discovered that short-chain fatty acids produced by intestinal bacteria regulate a crucial step in this process, the extension of dendritic 'arms.' This breakthrough finding could potentially lead to the development of disease prevention strategies involving beneficial bacteria and new drugs targeting the regulation of dendritic cell function.

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Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.

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Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers.   

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Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.

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Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell. A study suggests that mammalian cells internalize phages as a resource to promote cellular growth and survival.

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Special proteins -- known as membrane transporters -- are key to the mobility of sperm cells. A research team has, with the aid of cryo-electron microscopy, succeeded in decoding the structure of such a transporter and its mechanism. These findings will enable a better understanding of the molecular foundations of reproductive capacity and could, in the long term, contribute to developing new approaches to treating fertility disorders and new methods of specific contraception.

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Mathematicians have invented a new statistical tool to analyze multiple outcomes from clinical trials, replacing the 60-year-old standard tool that could only look at binary outcomes (survived/ did not survive). This will allow researchers to ask more complex research questions with trials that involve fewer patients, thereby streamlining the process of getting effective treatments to patients.

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A team of researchers has gained new insights into the respiratory system of fruit flies -- the so-called tracheal system -- which could be important for future research into aneurysms. Scientists carried out genetic, cell biological and biochemical studies on Drosophila embryos. They found that the cells in the fruit fly's tracheal system are connected to the extracellular matrix by the proteins Dumpy and Piopio.

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Eggs of the mosquito that carries Zika virus can tolerate extended desiccation by altering their metabolism, according to a new study. The finding offers potential new ways to control the spread of this mosquito.

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Researchers have solved the structure of a novel insecticidal protein that is effective in protecting major crop plants like corn and soybean from pests and is naturally produced by ferns.

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What if your house plant could tell you your water isn't safe? Scientists are closer to realizing this vision, having successfully engineered a plant to turn beet red in the presence of a banned, toxic pesticide. 

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Stimulating muscle fibers with magnets causes them to grow in the same direction, aligning muscle cells within tissue. The findings offer a simpler, less time-consuming way for medical researchers to program muscle cell alignment, which is strongly tied to healthy muscle function.

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The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. Investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics.

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A new study reveals the pitfalls of deep generative models when they are tasked with solving engineering design problems. The researchers say if mechanical engineers want help from AI for novel ideas and designs, they'll have to refocus those models beyond 'statistical similarity.' 

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Turning unused waste from food production into clean energy: Researchers are using chicken feathers to make fuel cells more cost-effective and sustainable.

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Proteins are important molecules that perform a variety of functions essential to life. To function properly, many proteins must fold into specific structures. However, the way proteins fold into specific structures is still largely unknown. Researchers have developed a novel physical theory that can accurately predict how proteins fold. Their model can predict things previous models cannot. Improved knowledge of protein folding could offer huge benefits to medical research, as well as to various industrial processes.

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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.

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New soft, implantable fibers can deliver light to major nerves through the body. They are an experimental tool for scientists to explore the causes and potential treatments for peripheral nerve disorders in animal models.

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A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies.

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A research group has developed a new method for studying how cancer cells function in softer and stiffer tissue environments. This insight challenges the existing paradigm, opening up new possibilities for research in cancer biology and tissue engineering.