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Categories: Biology: Molecular, Mathematics: Statistics
Published New approach to fighting malaria
(via sciencedaily.com) Original source Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.
Published Unlocking the secrets of cell antennas
(via sciencedaily.com) Original source The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.
Published Researchers describe rebuilding, regenerating lung cells
(via sciencedaily.com) Original source Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.
Published The 'treadmill conveyor belt' ensuring proper cell division
(via sciencedaily.com) Original source Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.
Published Researchers target lifecycle of parasite behind Chagas disease
(via sciencedaily.com) Original source Researchers are studying the signaling pathway that leads the parasite responsible for Chagas disease to transform and reproduce. They follow that pathway from the beginning when an uninfected kissing bug acquires the parasite by biting an infected mammal host all the way to the time the parasite develops in the insect's gut to be spread to people or animals through the bug's poop.
Published Researchers unearth a new process by which algae pass on nurtrients to their coral host
(via sciencedaily.com) Researchers have identified a new pathway by which sugar is released by symbiotic algae. This pathway involves the largely overlooked cell wall, showing that this structure not only protects the cell but plays an important role in symbiosis and carbon circulation in the ocean.
Published High-fat diets alter gut bacteria, boosting colorectal cancer risk in mice
(via sciencedaily.com) Original source Researchers have discovered how high-fat diets can change gut bacteria and alter digestive molecules called bile acids that are modified by those bacteria, predisposing mice to colorectal cancer. The findings bring scientists closer to understanding the causes of and how to prevent colorectal cancer.
Published Research team developing a nano-sized force sensor and improving high-precision microscopy technology
(via sciencedaily.com) Recent research in cell biology highlights groundbreaking results. An international team of researchers have recently established a tool they developed to study the mechanics of the cell. The tool can be used to study the inner forces of the cell, for example, the stretching of the nuclear membrane. The microscopic force sensor, only about 0.00002 mm long, is constructed of exotic ingredients such as spider web protein parts, fluorescent proteins from jellyfish, and antibodies from alpaca. In addition, the multidisciplinary team of researchers has developed further the sensitivity of super-resolution microscopy technique.
Published 'Viral relicts' in the genome could fuel neurodegeneration
(via sciencedaily.com) Original source Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures.
Published Ancient metal cauldrons give us clues about what people ate in the Bronze Age
(via sciencedaily.com) Original source Archaeologists have long been drawing conclusions about how ancient tools were used by the people who crafted them based on written records and context clues. But with dietary practices, they have had to make assumptions about what was eaten and how it was prepared. A new study analyzed protein residues from ancient cooking cauldrons and found that the people of Caucasus ate deer, sheep, goats, and members of the cow family during the Maykop period (3700--2900 BCE).
Published Increasing legumes and reducing red meat is safe for bone health and protein intake
(via sciencedaily.com) Original source A study has demonstrated that the partial substitution of red and processed meat with pea- and faba bean -- based food products ensured sufficient intake of amino acids in the diet and did not negatively affect bone metabolism.
Published Scientists reveal how sensory protein changes shape with nanometer resolution
(via sciencedaily.com) The sensory receptor PIEZO1 changes shape in response to mechanical stimuli. The super high-resolution microscopy technology used in this discovery is a breakthrough in enabling protein structures to be studied within the cellular environment.
Published AI transformation of medicine: Why doctors are not prepared
(via sciencedaily.com) The success of artificial intelligence technologies depends largely on how physicians interpret and act upon a tool's risk predictions -- and that requires a unique set of skills that many are currently lacking, according to a new perspective article.
Published How good is that AI-penned radiology report?
(via sciencedaily.com) New study identifies concerning gaps between how human radiologists score the accuracy of AI-generated radiology reports and how automated systems score them. Researchers designed two novel scoring systems that outperform current automated systems that evaluate the accuracy of AI narrative reports. Reliable scoring systems that accurately gauge the performance of AI models are critical for ensuring that AI continues to improve and that clinicians can trust them.
Published Breakthrough in Monte Carlo computer simulations
(via sciencedaily.com) Researchers have developed a highly efficient method to investigate systems with long-range interactions that were previously puzzling to experts. These systems can be gases or even solid materials such as magnets whose atoms interact not only with their neighbors but also far beyond.
Published Efficient discovery of improved energy materials by a new AI-guided workflow
(via sciencedaily.com) Scientists have recently proposed a workflow that can dramatically accelerate the search for novel materials with improved properties. They demonstrated the power of the approach by identifying more than 50 strongly thermally insulating materials. These can help alleviate the ongoing energy crisis, by allowing for more efficient thermoelectric elements, i.e., devices able to convert otherwise wasted heat into useful electrical voltage.
Published Participating in genetic studies is in your genes
(via sciencedaily.com) Original source Why do some people take part in genetic studies while others do not? The answer may lie within our genetic makeup. According to a groundbreaking study, people who participate in genetic studies are genetically more likely to do so, leaving detectable 'footprints' in genetics data. This breakthrough equips researchers with the ability to identify and address participation bias, a significant challenge in genetic research.
Published Number cruncher calculates whether whales are acting weirdly
(via sciencedaily.com) Original source We humans can be a scary acquaintance for whales in the wild. This includes marine biologists tagging them with measuring devices to understand them better. These experiences can make whales behave erratically for a while. Such behaviour can affect research quality and highlights an animal ethics dilemma. Now, researchers have figured out how to solve the problems with math.
Published Geologists are using artificial intelligence to predict landslides
(via sciencedaily.com) Original source Many factors influence where a landslide will occur, including the shape of the terrain, its slope and drainage areas, the material properties of soil and bedrock, and environmental conditions like climate, rainfall, hydrology and ground motion resulting from earthquakes. Geologists have developed a new technique that uses artificial intelligence to better predict where and why landslides may occur could bolster efforts to protect lives and property in some of the world's most disaster-prone areas. The new method improves the accuracy and interpretability of AI-based machine-learning techniques, requires far less computing power and is more broadly applicable than traditional predictive models.
Published Researchers develop digital test to directly measure HIV viral load
(via sciencedaily.com) Original source A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression. The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in single drop of blood.