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Categories: Biology: Molecular, Ecology: General
Published New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells
(via sciencedaily.com) Original source Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process. Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells.
Published The mystery of phosphite -- a scientific detective story
(via sciencedaily.com) Original source Biologists have discovered a phosphorus-based bacterial metabolism that is both new and ancient. In a special role: a calculation from the 1980s, a sewage plant, a new bacterial organism, and a remnant from around 2.5 billion years ago.
Published Yeast cells can produce drugs for treatment of psychotic disorders
(via sciencedaily.com) Original source An international team of researchers has demonstrated that genetically engineered yeast cells can produce the natural plant product alstonine, which has shown positive effects in treating schizophrenia.
Published Team creates synthetic enzymes to unravel molecular mysteries
(via sciencedaily.com) Original source A bioengineer has developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in the development of muscle, bone and blood in vertebrate embryos. The team of researchers is using a new approach, called the Synthetic Processing (SynPro) system, in zebrafish to study how Vg1 is formed. By learning the molecular rules of signal formation in a developing animal, researchers aim to engineer mechanisms -- such as giving cells new instructions -- that could play a role in treating or preventing disease.
Published Scientists use quantum biology, AI to sharpen genome editing tool
(via sciencedaily.com) Original source Scientists used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
Published First live birth of a chimeric monkey using embryonic stem cell lines
(via sciencedaily.com) Original source A team of researchers has reported for the first time the live birth of a monkey that contains a high proportion of cells derived from a monkey stem cell line. This 'chimeric' monkey is composed of cells that originate from two genetically distinct embryos of the same species of monkey. This has previously been demonstrated in rats and mice but, until now, has not been possible in other species, including non-human primates.
Published Zen and the art of mitochondrial maintenance: The machinery of death makes a healthier life
(via sciencedaily.com) Original source While we all aspire for a long lifespan, what is most coveted is a long period of vigor and health, or 'healthspan,' that precedes the inevitable decline of advancing age. Researchers have discovered that instruments of death that cells use to commit suicide when things go wrong contribute to making a longer and healthier life by revitalizing the specialized cellular compartments called mitochondria.
Published Temperature increase triggers viral infection
(via sciencedaily.com) Original source Researchers have mapped on an atomic level what happens in a virus particle when the temperature is raised.
Published A fifth of European Red List flora and fauna species may be at risk of extinction
(via sciencedaily.com) Original source A new analysis of 14,669 threatened species of plants and animals found in Europe reveals that about one fifth face the risk of extinction, and that agricultural land-use change poses a significant threat to these species.
Published Southern Alaska's national forests key to meeting climate, conservation goals
(via sciencedaily.com) Original source Analyses of U.S. national forests shows that increased protections for two Alaskan forests is a key to meeting climate and biodiversity goals.
Published Experts predict 'catastrophic ecosystem collapse' of UK forests within the next 50 years if action not taken
(via sciencedaily.com) Original source Experts predict 'catastrophic ecosystem collapse' of UK forests within the next 50 years if action not taken. Other threats to UK forests include competition with society for water, viral diseases, and extreme weather affecting forest management.
Published Device 'smells' seawater to discover, detect novel molecules
(via sciencedaily.com) Original source Under the ocean's surface, marine organisms are constantly releasing invisible molecules. Some of the chemical clues reveal which creatures are nearby, while others could be used someday as medications. Now, researchers report a proof-of-concept device that 'sniffs' seawater, trapping dissolved compounds for analyses. The team showed that the system could easily concentrate molecules that are present in underwater caves and holds promise for drug discovery in fragile ecosystems, including coral reefs.
Published Yeast with an over half synthetic genome is created in the lab
(via sciencedaily.com) Original source Researchers have combined over seven synthetic chromosomes that were made in the lab into a single yeast cell, resulting in a strain with more than 50% synthetic DNA that survives and replicates similarly to wild yeast strains. A global consortium is working to develop the first synthetic eukaryote genome from scratch. The team has now synthesized and debugged all sixteen yeast chromosomes.
Published Scientists one step closer to re-writing world's first synthetic yeast genome, unravelling the fundamental building blocks of life
(via sciencedaily.com) Original source Scientists have engineered a chromosome entirely from scratch that will contribute to the production of the world's first synthetic yeast.
Published Scientists take major step towards completing the world's first synthetic yeast
(via sciencedaily.com) Original source A team of Scientists has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The work represents completion of one of the 16 chromosomes of the yeast genome, which is part of the biggest project ever in synthetic biology; the international synthetic yeast genome collaboration. The collaboration, known as 'Sc2.0' has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes. Alongside this paper, another 9 publications are also released today from other teams describing their synthetic chromosomes. The final completion of the genome project -- the largest synthetic genome ever -- is expected next year.
Published Obesity linked to neurodegeneration through insulin resistance
(via sciencedaily.com) Original source Researchers have discovered a link between obesity and neurodegenerative disorders like Alzheimer's disease. Using the common fruit fly, the research shows that a high-sugar diet -- a hallmark of obesity -- causes insulin resistance in the brain, which in turn reduces the ability to remove neuronal debris, thus increasing the risk of neurodegeneration.
Published 'Biodiversity time machine' provides insights into a century of loss
(via sciencedaily.com) Original source AI analysis shows pollution levels, extreme weather events and increasing temperatures devastates biodiversity in freshwater lakes.
Published City and highway lights threaten mountain lion habitats
(via sciencedaily.com) Original source Artificial light pollution at night threatens mountain lion habitat, making it a factor to consider for wildlife crossings and land use, finds a new study.
Published New algae species rewrites understanding of reef systems
(via sciencedaily.com) Original source An international team of marine scientists has identified and officially named four species of algae new to science, challenging previous taxonomical assumptions within the Porolithon genus. The discovery has far-reaching implications for our understanding of the ecological role of these algae in the coral reef ecosystem.
Published Threatened sharks and rays caught off Cyprus
(via sciencedaily.com) Original source Sharks and rays from threatened species are being caught off northern Cyprus, according to a new study by scientists who are working with local authorities and fishers to protect the animals.