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Categories: Biology: Molecular, Ecology: Research
Published New deep-learning model outperforms Google AI system in predicting peptide structures
(via sciencedaily.com) Original source Researchers have developed a deep-learning model, called PepFlow, that can predict all possible shapes of peptides -- chains of amino acids that are shorter than proteins, but perform similar biological functions. Peptides are known to be highly flexible, taking on a wide range of folding patterns, and are thus involved in many biological processes of interest to researchers in the development of therapeutics.
Published Wolves reintroduced to Isle Royale temporarily affect other carnivores, humans have influence as well
(via sciencedaily.com) Original source In a rare opportunity to study carnivores before and after wolves were reintroduced to their ranges, researchers found that the effects of wolves on Isle Royale have been only temporary. And even in the least-visited national park, humans had a more significant impact on carnivores' lives.
Published A promising weapon against measles
(via sciencedaily.com) Original source What happens when measles virus meets a human cell? The viral machinery unfolds in just the right way to reveal key pieces that let it fuse itself into the host cell membrane.
Published Potent therapy candidate for fatal prion diseases
(via sciencedaily.com) Original source Scientists have developed a gene-silencing tool that shows promise as a therapy against fatal prion diseases. The tool, a streamlined epigenetic editor, paves the way for a new class of genetic approaches to treat certain diseases.
Published New, holistic way to teach synthetic biology
(via sciencedaily.com) Original source Synthetic biology combines principles from science, engineering and social science, creating emerging technologies such as alternative meats and mRNA vaccines; Deconstructing synthetic biology across scales gives rise to new approach to uniting traditional disciplines; Case studies offer a modular, accessible approach to teaching at different institutions.
Published From takeoff to flight, the wiring of a fly's nervous system is mapped
(via sciencedaily.com) Original source Although a fly's motor neurons are few, it performs remarkable aerial and terrestrial feats. A wiring diagram recently created of the motor circuits in the central nervous system of the fruit fly is providing detailed information on how the nerve coordination of leg movements differs from that controlling the wings. Such studies reveal the unexpected complexity of the fly's tiny motor system. They also advance the understanding of how the central nervous system in animals coordinates individual muscles to carry out a variety of behaviors.
Published Cell division: Before commitment, a very long engagement
(via sciencedaily.com) Original source Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours -- sometimes more than a day -- in a reversible intermediate state, according to a new discovery. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.
Published Unlocking the world of bacteria
(via sciencedaily.com) Original source Bacteria possess unique traits with great potential for benefiting society. However, current genetic engineering methods to harness these advantages are limited to a small fraction of bacterial species. A team has now introduced a novel approach that can make many more bacteria amenable to genetic engineering. Their method, called IMPRINT, uses cell-free systems to enhance DNA transformation across various bacterial strains.
Published The on-and-off affair in DNA
(via sciencedaily.com) Original source Researchers have discovered that in thale cresses histone H3 lysine-9 (H3K9) methylation, conventionally thought to be a mark of turning off gene transcription, can also turn on gene expression via the interactions of two other proteins and histone marks. The molecular mechanisms demonstrate that rather than functioning as a simple 'off switch,' H3K9 methylation is more like a 'dimmer switch' that fine-tunes DNA transcription. The discovery suggests there might be similar mechanisms in other organisms, too.
Published Future risk of coral bleaching set to intensify globally
(via sciencedaily.com) Original source Researchers have projected future marine heatwaves will cause coral reefs to be at severe risk of bleaching for longer periods than previously seen.
Published Slipping a note to a neighbor: The cellular way
(via sciencedaily.com) Original source Study reveals how drug molecules bind in channels between neighboring cells, changing intercellular communication.
Published Plankton researchers urge their colleagues to mix it up
(via sciencedaily.com) Original source A new article encourages researchers to focus their attention on mixoplankton, providing a set of methodologies to help expand our understanding of this critically important component of the marine ecosystem.
Published Revealing the dynamic choreography inside multilayer vesicles
(via sciencedaily.com) Original source Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles -- structures that transport waste or food within cells. In a recent paper, researchers shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.
Published Frog 'saunas' a lifeline for endangered frog populations
(via sciencedaily.com) Original source New biologist-designed shelters will help endangered frogs survive the devastating impacts of a deadly fungal disease by regulating their body temperature to fight off infections.
Published Zebrafish reveal how bioelectricity shapes muscle development
(via sciencedaily.com) Original source New research describes how nerve cells and muscle cells communicate through electrical signals during development -- a phenomenon known as bioelectricity. The communication, which takes place via specialized channels between cells, is vital for proper development and behavior. The study identifies specific genes that control the process, and pins down what happens when it goes wrong. The finding offers clues to the genetic origins of muscle disorders in humans.
Published Discovery of vast sex differences in cellular activity has major implications for disease treatment
(via sciencedaily.com) Original source The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.
Published Myths about intermittent fasting, debunked
(via sciencedaily.com) Original source Research shows that the increasingly popular weight-loss strategy is safe. Intermittent fasting has become an increasingly popular way to lose weight without counting calories. And a large body of research has shown it s safe. Still, several myths about fasting have gained traction.
Published Fuel treatments reduce future wildfire severity
(via sciencedaily.com) Original source There is a common belief that prescribed burning, thinning trees, and clearing underbrush reduce risks of the severity of future fires. But is that true? A new project analyzing 40 studies where wildfire burned into different vegetation treatments, spanning 11 western states. Researchers found overwhelming evidence that in seasonally dry mixed conifer forests in the western U.S., reducing surface and ladder fuels and tree density through thinning, coupled with prescribed burning or pile burning, could reduce future wildfire severity by more than 60% relative to untreated areas.
Published Removal of excess chloride ions by plants when subjected to salt stress
(via sciencedaily.com) Original source Researchers have discovered a salt adaptation mechanism in plants that facilitates chloride removal from the roots and enhancing salinity tolerance. A research team has uncovered a novel mechanism of plant adaptation to salt stress involving the NaCl-induced translocation of a specific chloride channel protein, AtCLCf.
Published How cells boost gene expression
(via sciencedaily.com) Original source The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.