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Categories: Biology: Molecular, Ecology: Animals

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All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.

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A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.

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Early experiences in an animal's life can have a significant impact on its capacity to thrive, even years or decades later, and DNA methylation may help record their effects. In a study of 256 wild baboons, researchers found that resource limitation during early life was associated with many differences in DNA methylation, a small chemical mark on the DNA sequence that can affect gene activity.

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Entropy is often associated with disorder and chaos, but in biology it is related to energy efficiency and is closely linked to metabolism, the set of chemical reactions that sustain life. An international research team has now developed a novel methodology for the measurement of entropy production at the scale of a nanometer, meaning one-billionth of a meter. The new approach enabled the scientists to measure the heat flow, known as the entropy production rate, of single red blood cells.

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Global change is altering the physiology of the hibernation and behavior of bats, according to a study carried out over a twenty year period. Given the milder winters we are having, bats are accumulating less fat reserves in autumn, they shorten their hibernation periods and they leave their winter shelter sooner. These changes could alter the migration pattern of bats and the phenology of their seasonal displacements.

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An updated method for directly observing physical interactions between cells, could allow scientists to one day map every possible cell interaction.

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'Random DNA' is naturally active in the one-celled fungi yeast, while such DNA is turned off as its natural state in mammalian cells, despite their having a common ancestor a billion years ago and the same basic molecular machinery, a new study finds.

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Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected cells. A major study now provides important new insights into how complex epigenetic modification signatures regulate the genome. This study will pave the way for new treatments of diseases caused by faulty epigenetic machineries.

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Researchers shed light on archaea, intriguing microbes found in extreme environments but also in the human gut microbiome.

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Fossils of a strange new species of marine lizard with dagger-like teeth that lived 66 million years ago, show a dramatically more biodiverse ocean ecosystem to what we see today.

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A globally distributed single-celled organism that occurs in harmful algal blooms has been found to exhibit an unusual organisation of photosynthesis. Researchers have taken a closer look at the unusual cell biology of the species Prorocentrum cordatum from the group of dinoflagellates. The results of their study could help to better understand the role of the species in the environment and the increased occurrence of algal blooms at higher water temperatures.

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These reptiles move around tree trunks to seek warmth or shade. With trees disappearing, they would have trouble controlling their body temperature, a new study shows.

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Scientists provide fresh insights on the origins of life, presenting compelling evidence supporting the 'RNA World' hypothesis. The study unveils an RNA enzyme that can make accurate copies of other functional RNA strands, while also allowing new variants of the molecule to emerge over time. These remarkable capabilities suggest the earliest forms of evolution may have occurred on a molecular scale in RNA, and also bring scientists one step closer to re-creating autonomous RNA-based life in the laboratory.

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Secrets of photosynthesis have been discovered at atomic level, shedding important new light on this plant super-power that greened the earth more than a billion years ago.

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When certain species of wild birds and primates discover new ways of finding food in the wild, it can serve to measure their flexibility and intelligence. In the largest experimental study ever conducted on this topic, researchers have shown that foraging problems requiring overcoming obstacles, such as removing the lid off a container of food, are the only predictors of brain size and innovative behavior in the wild.

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An orca (killer whale) has been observed, for the first-ever time, individually consuming a great white shark -- and within just two minutes.

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Researchers identified the proteins of a CO2-fixing organelle, namely, 'pyrenoid,' in the marine algal group Chlorarachniophyta and revealed various pyrenoid-associated proteins among algal groups, suggesting the independent evolution of pyrenoids in different algal groups.

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Researchers succeed at generating 3D visualizations of chloroplasts' copying machines.

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Researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi's sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.

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Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat. They also are modified extensively by bacteria, which greatly expand the types of bile acids found in the host. For most of a century, scientists believed that was the end of the bile-acid story. Recent technological advances, however, have led to a greater understanding of the origins of bile acids as well as their chemical relationships to the organisms in the gut microbiome and their host.