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Categories: Biology: Developmental, Biology: Molecular
Published Precise package delivery in cells?
(via sciencedaily.com) Original source Researchers have developed new real-time microscopy technology and successfully observed the behavior of 'motor proteins', which may hold the key to unraveling the efficient material transport strategy of cells.
Published Breakthrough in plant disease: New enzyme could lead to anti-bacterial pesticides
(via sciencedaily.com) Original source Scientists uncover a pivotal enzyme, XccOpgD, and its critical role in synthesizing C G16, a key compound used by Xanthomonas pathogens to enhance their virulence against plants. This breakthrough opens new avenues for developing targeted pesticides that combat plant diseases without harming beneficial organisms. Insights into XccOpgD's enzymatic mechanism and optimal conditions offer promising prospects for sustainable agriculture, bolstering crop resilience and global food security while minimizing environmental impact.
Published Talking about regeneration
(via sciencedaily.com) Original source Researchers transferred genes from simple organisms capable of regenerating their bodies into common fruit flies, more complex animals that cannot. They found the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest studying genes specific to animals with high regenerative capability may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.
Published Mass extinction 66 million years ago triggered rapid evolution of bird genomes
(via sciencedaily.com) Original source Study finds that the mass extinction caused by an asteroid about 66 million years ago led to critical changes in bird genomes that ultimately sparked the incredibly diversity living birds.
Published The next generation of RNA chips
(via sciencedaily.com) Original source An international research team has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research. The chemical synthesis of these chips is now twice as fast and seven times more efficient.
Published New principle for treating tuberculosis
(via sciencedaily.com) Original source Researchers have succeeded in identifying and synthesizing a group of molecules that can act against the cause of tuberculosis in a new way. They describe that the so-called callyaerins act against the infectious disease by employing a fundamentally different mechanism compared to antibiotic agents used to date.
Published Unraveling a key junction underlying muscle contraction
(via sciencedaily.com) Original source Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal kingdom and setting the stage for possible future treatments for muscular disorders.
Published Precise genetics: New CRISPR method enables efficient DNA modification
(via sciencedaily.com) Original source A research group has developed a new method that further improves the existing CRISPR/Cas technologies: it allows a more precise and seamless introduction of tags into proteins at the gene level. This technology could significantly improve research on proteins in living organisms and opens up new possibilities for medical research.
Published Platypus and chicken reveal how chromosomes balance between the sexes
(via sciencedaily.com) Original source Geneticists uncover new insights into how sex chromosome systems work in the platypus and the chicken -- which will lead to better understandings of our own sex chromosome evolution and gene regulation.
Published How researchers turn bacteria into cellulose-producing mini-factories
(via sciencedaily.com) Original source Researchers have modified certain bacteria with UV light so that they produce more cellulose. The basis for this is a new approach with which the researchers generate thousands of bacterial variants and select those that have developed into the most productive.
Published MicroRNA study sets stage for crop improvements
(via sciencedaily.com) Original source MicroRNAs can make plants more capable of withstanding drought, salinity, pathogens and more. However, in a recent study scientists showed just how much we didn't know about the intricate processes plants use to produce them.
Published Fetal brain impacted when mom fights severe flu: New mouse study explains how
(via sciencedaily.com) Original source New research using live mouse-adapted influenza virus improves upon previous mouse experiments to explain how maternal infection impacts fetal brain development. The study also indicates fetal brain changes are more likely once the severity of the mother's infection meets a specific threshold.
Published Researchers decipher new molecular mechanisms related to biological tissue regeneration
(via sciencedaily.com) Original source A study opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor- (TNF- ) and its receptors TNFR, molecules of key interest in biomedicine due to their involvement in multiple diseases such as obesity related to type 2 diabetes mellitus, inflammatory bowel disease and several types of cancer.
Published Lampreys possess a 'jaw-dropping' evolutionary origin
(via sciencedaily.com) Original source Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.
Published New drug shows promise in clearing HIV from brain
(via sciencedaily.com) Original source An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.
Published New groups of methane-producing organisms in Yellowstone
(via sciencedaily.com) Original source The team verified that microbes found in Yellowstone National Park hot springs produce methane to grow.
Published Researchers are closing in on a mouse model for late-onset Alzheimer's
(via sciencedaily.com) Original source Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.
Published Research sheds light on the role of PTPRK in tissue repair and cancer
(via sciencedaily.com) Original source New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.
Published Under pressure: How cells respond to physical stress
(via sciencedaily.com) Original source Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.
Published Dual action antibiotic could make bacterial resistance nearly impossible
(via sciencedaily.com) Original source New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.