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Categories: Biology: Developmental, Biology: Molecular

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A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.

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Scientists have succeeded in pinpointing the neurons within a female fruit fly's brain that respond to signals from the male during mating.

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Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease. Now, research uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.

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Researchers have found a new way to identify genetic targets useful for control of mosquito populations, potentially offering an alternative to insecticides. Their study focused on the genetic basis of species incompatibility. They crossed Ae. aegypti, a major global arboviral disease vector, and its sibling species, Ae. mascarensis, from the Indian Ocean. When offspring is crossed back with one parent, about 10 percent of the progeny becomes intersex and is unable to reproduce.

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A bitter taste is traditionally considered a warning sign of potentially toxic substances. But not all bitter substances are harmful. For example, some peptides and free amino acids taste bitter, even though they are non-toxic, nutritious and sometimes even vital for humans. A new study now offers an explanation for this seemingly paradoxical phenomenon.

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A little leg may reveal something big about how closely related insect species can drastically differ in body shape, according to a new study. The team imaged live cells of fruit flies in the last stages of development over several days and found a new structure that appears to help guide a section of the leg into its final shape.

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New research is shedding light on how viruses ensure their survival by precisely timing the release of new viruses. The discovery offers a new theoretical framework for understanding these dynamic biological phenomena.

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The human genome is filled with flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago. Scientists used to think they were harmless, but new research shows that, when reawakened, they help cancer survive and thrive.

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High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results suggest caution when following these diets.

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Genomes can now be used to store information about a variety of transient biological events inside of living cells, as they happen, like a flight recorder collecting data from an aircraft. The method, called ENGRAM, aims to turn cells into their own historians. ENGRAM couples each kind of biological signal or event inside a cell to a symbolic barcode. This new strategy traces and archives the type and timing of biological signals inside the cell by inserting this information into the genome. For example, this record-keeping can track the commands that turn genes on or off.

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Most influenza viruses enter human or animal cells through specific pathways on the cells' surface. Researchers have now discovered that certain human flu viruses and avian flu viruses can also use a second entry pathway, a protein complex of the immune system, to infect cells. This ability helps the viruses infect different species -- and potentially jump between animals and humans.

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CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.

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Research achieves scientific breakthrough in understanding cell division.

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Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system. For analysis of the necessary complex antigen processing and transport processes in real time, researchers have developed a 'cage' that is opened with light to release trapped antigens at a specific place and time.

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Researchers have discovered that a single-celled organism, a close relative of animals, harbors the remnants of ancient giant viruses woven into its own genetic code. This finding sheds light on how complex organisms may have acquired some of their genes and highlights the dynamic interplay between viruses and their hosts.

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A study opens new possibilities to improve production efficiency in the cattle industry and potentially animal agriculture more broadly.

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Scientists have successfully created mechanical force sensors directly in the developing brains and spinal cords of chicken embryos, which they hope will improve understanding and prevention of birth malformations such as spina bifida.

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RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste. Researchers report a new, enzyme-based RNA synthesis method that can produce strands of RNA with both natural and modified nucleotides without the environmental hazards.

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The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study.

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Researchers have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS) -- commonly known as forever chemicals -- disrupt biomolecular structure and function. The work shows that the compounds can alter proteins found in human breast milk and infant formulas -- potentially causing developmental issues downstream.