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Categories: Biology: Biotechnology, Biology: Molecular
Published Watch these cells rapidly create protrusions for exploration and movement
(via sciencedaily.com) Original source In order to move, cells must be able to rapidly change shape. A team of researchers show that cells achieve this by storing extra 'skin' in folds and bumps on their surface. This cell surface excess can be rapidly deployed to cover temporary protrusions and then folded away for next time.
Published Scales or feathers? It all comes down to a few genes
(via sciencedaily.com) Original source Scales, spines, feathers and hair are examples of vertebrate skin appendages, which constitute a remarkably diverse group of micro-organs. Despite their natural multitude of forms, these appendages share early developmental processes at the embryonic stage. Researchers have discovered how to permanently transform the scales that normally cover the feet of chickens into feathers, by specifically modifying the expression of certain genes.
Published A channel involved in pain sensation can also suppress it
(via sciencedaily.com) Original source Pain is good. It's the body's way to keep an animal from harming itself or repeating a dangerous mistake. But sometimes the debilitating sensation can get in the way. So evolution has devised ways to tamp that response down under certain circumstances.
Published Researchers reveal DNA repair mechanism
(via sciencedaily.com) Original source A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.
Published How superbug A. baumannii survives metal stress and resists antibiotics
(via sciencedaily.com) Original source The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.
Published Phage structure captured, to benefit biotech applications
(via sciencedaily.com) Original source Researchers have mapped out what a commonly-used form of phage looks like, which will help design better uses in future.
Published Researcher uses mammal DNA to zoom into the human genome with unprecedented resolution
(via sciencedaily.com) Original source Scientists have precisely identified base pairs of the human genome that remained consistent over millions of years of mammalian evolution, and which play a crucial role in human disease. The team analyzed the genomes of 240 mammals, including humans and identified base pairs that were 'constrained' -- meaning they remained generally consistent -- across mammal species over the course of evolution. The most constrained base pairs in mammals were over seven times more likely to be causal for human disease and complex trait, and over 11 times more likely when researchers looked at the most constrained base pairs in primates alone.
Published A look inside stem cells helps create personalized regenerative medicine
(via sciencedaily.com) Original source Researchers have examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.
Published Brain-belly connection: Gut health may influence likelihood of developing Alzheimer's
(via sciencedaily.com) Original source A new study pinpoints 10 bacterial groups associated with Alzheimer's disease, provides new insights into the relationship between gut makeup and dementia.
Published Ancestral mitoviruses discovered in mycorrhizal fungi
(via sciencedaily.com) Original source A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.
Published Bacteria killing material could tackle hospital superbugs
(via sciencedaily.com) Original source Researchers have used a common disinfectant and antiseptic to create a new antimicrobial coating material that effectively kills bacteria and viruses, including MRSA and SARS-COV-2.
Published Bacteria: Radioactive elements replace essential rare earth metals
(via sciencedaily.com) Original source Bacteria can use certain radioactive elements to sustain their metabolism.
Published How bacteria evolve resistance to antibiotics
(via sciencedaily.com) Original source Bacteria can rapidly evolve resistance to antibiotics by adapting special pumps to flush them out of their cells, according to new research. Antimicrobial resistance is a growing problem of global significance. The rise of resistant 'superbugs' threatens our ability to use antimicrobials like antibiotics to treat and prevent the spread of infections caused by microorganisms. It is hoped that the findings will improve how antibiotics are used to help prevent further spread of antimicrobial resistance.
Published Scientists create CRISPR-based drug candidate targeting the microbiome
(via sciencedaily.com) Original source A new drug candidate targeting E. coli in the gut is in phase 1 clinical trials. According to a new paper it may improve the well-being of blood cancer patients and reduce their mortality rate from E. coli infections.
Published 'Super-resolution' imaging technology
(via sciencedaily.com) Original source Researchers describe developing a super-resolution imaging platform technology to improve understanding of how nanoparticles interact within cells.
Published Scientists develop gene silencing DNA enzyme that can target a single molecule
(via sciencedaily.com) Original source Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.
Published T cells can activate themselves to fight tumors
(via sciencedaily.com) Original source Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.
Published New probe aids novel findings on cell functions
(via sciencedaily.com) Original source New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.
Published An unprecedented view of gene regulation
(via sciencedaily.com) Original source Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.
Published Tiny microbes could brew big benefits for green biomanufacturing
(via sciencedaily.com) Original source Scientists find new route in bacteria to decarbonize industry. The discovery could reduce greenhouse gas emissions from the manufacturing of fuels, drugs, and chemicals. A research team has engineered bacteria to produce new-to-nature carbon products that could provide a powerful route to sustainable biochemicals.