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Categories: Biology: Biotechnology, Biology: Molecular
Published Researchers discover a way to fight the aging process and cancer development
(via sciencedaily.com) Damage in the human genome can be repaired. But this works better in germ cells, sperm and eggs, than in normal body cells. Responsible for this is the DREAM protein complex, which prevents the activation of all available repair mechanisms. A research team has now shown that normal body cells can also be repaired better once this complex has been deactivated. In the long run, the scientists hope to develop better therapies to prevent cancer and aging-associated diseases.
Published Without this, plants cannot respond to temperature
(via sciencedaily.com) Scientists have significantly advanced the race to control plant responses to temperature on a rapidly warming planet. Key to this breakthrough is miRNA, a molecule nearly 200,000 times smaller than the width of a human hair.
Published Genome of a drought-tolerant plant: Many genes are involved in 'resurrection'
(via sciencedaily.com) Some plants can survive months without water, only to turn green again after a brief downpour. A recent study shows that this is not due to a 'miracle gene.' Rather, this ability is a consequence of a whole network of genes, almost all of which are also present in more vulnerable varieties.
Published Memory B cell marker predicts long-lived antibody response to flu vaccine
(via sciencedaily.com) Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. Researchers have now described a distinct and novel subset of memory B cells that predict long-lived antibody responses to influenza vaccination in humans. These effector memory B cells appear to be poised for a rapid serum antibody response upon secondary challenge one year later.
Published Researchers create artificial enzyme for fast detection of disease-related hormone in sweat
(via sciencedaily.com) Researchers have developed a handheld sensor that tests perspiration for cortisol and provides results in eight minutes, a key advance in monitoring a hormone whose levels are a marker for many illnesses including various cancers.
Published Photosynthesis 'hack' could lead to new ways of generating renewable energy
(via sciencedaily.com) Researchers have 'hacked' the earliest stages of photosynthesis, the natural machine that powers the vast majority of life on Earth, and discovered new ways to extract energy from the process, a finding that could lead to new ways of generating clean fuel and renewable energy.
Published Novel drug makes mice skinny even on sugary, fatty diet
(via sciencedaily.com) Deleting a gene that promotes magnesium transport into mitochondria (which are cells' power plants) resulted in more efficient metabolism of sugar and fat in the energy centers. The result: skinny, healthy mice. Now the research team, has developed a small-molecule drug that accomplishes the same effect in mice.
Published To ward off aging, stem cells must take out the trash
(via sciencedaily.com) Researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.
Published In hot water: Ocean warming impacts growth, metabolic rate and gene activity of newly hatched clownfish
(via sciencedaily.com) Future ocean warming and marine heatwaves could impact the growth and development of clownfish during their earliest life stages, suggests a new study.
Published Scientists use tardigrade proteins for human health breakthrough
(via sciencedaily.com) Original source Natural and engineered versions of tardigrade proteins can be used to stabilize an important pharmaceutical used to treat people with hemophilia and other conditions without the need for refrigeration -- even amid high temperatures and other difficult conditions.
Published Muscle health depends on lipid synthesis
(via sciencedaily.com) Original source Muscle degeneration, the most prevalent cause of frailty in hereditary diseases and aging, could be caused by a deficiency in one key enzyme in a lipid biosynthesis pathway. Researchers now characterize how the enzyme PCYT2 affects muscle health in disease and aging in laboratory mouse models.
Published Discovery of an unexpected function of blood immune cells: Their ability to proliferate
(via sciencedaily.com) The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell. It also allows the replacement of used cells from a limited number of 'stem' cells, which then proliferate and specialize. In cancer, however, cell proliferation is no longer controlled and becomes chaotic. Researchers have discovered that, in a healthy individual, certain blood immune cells, the monocytes, also have this ability to proliferate, with the aim to replace tissue macrophages, which are essential for the proper functioning of our body.
Published Discovery of root anatomy gene may lead to breeding more resilient corn crops
(via sciencedaily.com) A new discovery, reported in a global study that encompassed more than a decade of research, could lead to the breeding of corn crops that can withstand drought and low-nitrogen soil conditions and ultimately ease global food insecurity.
Published How can we tackle the biggest challenges? Ask a plant
(via sciencedaily.com) Without plants, we'd have no air to breathe or food to eat, yet plant science lingers in the shadowy wings while other fields take center stage. With the goal of shining the spotlight on plants, a new study presents the field's top 100 most pressing questions for research to address the greatest challenges facing humanity.
Published Study shines new light on ancient microbial dark matter
(via sciencedaily.com) An international research team produced the first large-scale analysis of more than 400 newly sequenced and existing Omnitrophota genomes, uncovering new details about their biology and behavior.
Published An extra X chromosome-linked gene may explain decreased viral infection severity in females
(via sciencedaily.com) It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery -- until possibly now. Researchers have found that female mouse and human Natural Killer cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.
Published Loss of Menin helps drive the aging process, and dietary supplement can reverse it in mice
(via sciencedaily.com) Decline in the hypothalamic Menin may play a key role in aging, according to a new study. The findings reveal a previously unknown driver of physiological aging, and suggest that supplementation with a simple amino acid may mitigate some age-related changes.
Published Humans bite back by deactivating mosquito sperm
(via sciencedaily.com) New research makes it likely that proteins responsible for activating mosquito sperm can be shut down, preventing them from swimming to or fertilizing eggs.
Published Compressive stress shapes the symmetry of Arabidopsis root vascular tissue
(via sciencedaily.com) A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that mechanical stress of the surrounding tissues guides growth in an apical-oriented manor, maintaining cell patterning throughout the tissue section.
Published Where the HI-Virus sleeps in the brain
(via sciencedaily.com) The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells.