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Categories: Biology: Biotechnology, Biology: Molecular
Published Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells
(via sciencedaily.com) Original source Creating a functional lung using interspecies chimeric animals is an attractive albeit challenging option for lung transplantation, requiring more research on the viable conditions needed for organ generation. A new study uses reverse-blastocyst complementation and tetraploid-based organ complementation methods to first determine these conditions in lung-deficient mice and then to generate rat-derived lungs in these mice. It provides useful insights on the intrinsic species-specific barriers and factors associated with lung development in interspecies chimeric animals.
Published A new approach can address antibiotic resistance to Mycobacterium abscessus
(via sciencedaily.com) Original source Scientists have created analogs of the antibiotic spectinomycin that are significantly more effective against these highly resistant bacteria.
Published Scientists engineer plant microbiome to protect crops against disease
(via sciencedaily.com) Original source Scientists have engineered the microbiome of plants for the first time, boosting the prevalence of 'good' bacteria that protect the plant from disease. The findings could substantially reduce the need for environmentally destructive pesticides.
Published New roles for autophagy genes in cellular waste management and aging
(via sciencedaily.com) Original source Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. Scientists have now uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins -- and ultimately affect aging.
Published The surprisingly resourceful ways bacteria thrive in the human gut
(via sciencedaily.com) Original source New research shows that some groups of bacteria in the gut are amazingly resourceful, with a large repertoire of genes that help them generate energy for themselves and potentially influence human health as well.
Published Scientists solve mystery of how predatory bacteria recognizes prey
(via sciencedaily.com) Original source A decades-old mystery of how natural antimicrobial predatory bacteria are able to recognize and kill other bacteria may have been solved, according to new research.
Published Treating tuberculosis when antibiotics no longer work
(via sciencedaily.com) Original source A research team has detected various substances that have a dual effect against tuberculosis: They make the bacteria causing the disease less pathogenic for human immune cells and boost the activity of conventional antibiotics.
Published Nematode proteins shed light on infertility
(via sciencedaily.com) Original source Biologists developed a method for illuminating the intricate interactions of the synaptonemal complex in the nematode C. elegans. The authors identified a trio of protein segments that guide chromosomal interactions, and pinpointed the location where they interact with each other. Their novel method uses a technique known as genetic suppressor screening, which can serve as a blueprint for research on large cellular assemblies that resist traditional structural analysis.
Published Study reveals clues to how Eastern equine encephalitis virus invades brain cells
(via sciencedaily.com) Original source Researchers have determined how Eastern equine encephalitis virus attaches to a receptor it uses to enter and infect cells. The findings laid the groundwork for a receptor decoy molecule that protects mice from encephalitis caused by the virus.
Published Bacteria load their syringes
(via sciencedaily.com) Original source Many bacterial pathogens use small injection apparatuses to manipulate the cells of their hosts, such as humans, so that they can spread throughout the body. To do this, they need to fill their syringes with the relevant injection agent. A technique that tracks the individual movement of proteins revealed how bacteria accomplish this challenging task.
Published New reasons eating less fat should be one of your resolutions
(via sciencedaily.com) Original source A new study to motivate your New Year's resolutions: it demonstrates that high-fat diets negatively impact genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system and brain function.
Published Elusive cytonemes guide neural development, provide signaling 'express route'
(via sciencedaily.com) Original source Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.
Published First step towards synthetic CO2 fixation in living cells
(via sciencedaily.com) Original source Three modules forming a new-to-nature CO2 fixation cycle have been successfully implemented in E.coli.
Published Big impacts from small changes in cell
(via sciencedaily.com) Original source Tiny things matter -- for instance, one amino acid can completely alter the architecture of the cell. Researchers have now investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin. Actin is found in all living cells where it has a range of important functions -- from muscle contraction to cell signalling and cell shape. This protein comes in two different varieties termed 'isoforms', which are known as gamma actin and beta actin.
Published How jellyfish regenerate functional tentacles in days
(via sciencedaily.com) Original source At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.
Published Researchers map how measles virus spreads in human brain
(via sciencedaily.com) Original source Researchers mapped how the measles virus mutated and spread in the brain of a person who succumbed to a rare, lethal brain disease. New cases of this disease, which is a complication of the measles virus, may occur as measles reemerges among the unvaccinated, say researchers.
Published GPCR structure: Research reveals molecular origins of function for a key drug target
(via sciencedaily.com) Original source Scientists reveal how G protein-coupled receptors, major therapeutic drug targets, decode critical properties of their ligands.
Published New tool unifies single-cell data
(via sciencedaily.com) Original source A new methodology that allows for the categorization and organization of single-cell data has been launched. It can be used to create a harmonized dataset for the study of human health and disease.
Published Location, location, location: The hidden power of intracellular neighborhoods
(via sciencedaily.com) Original source New findings provide details about the hidden organization of the cytoplasm, showing it makes a big difference where in that cellular broth that messenger RNA (mRNA) get translated into proteins. The findings hold promise for increasing or altering the production of proteins in mRNA vaccines and therapies.
Published The future of canine stem cell therapy: unprecedented, painless, and feeder-free
(via sciencedaily.com) Original source Scientists have developed an efficient, non-invasive, and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost canine iPSC generation by 120 times compared to conventional methods using fibroblasts. The iPSCs were created from urine-derived cells without the need for feeder cells, an impossible feat until now. Their findings are expected to advance regenerative medicine and genetic disease research in veterinary medicine.