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Categories: Biology: Cell Biology, Biology: Molecular
Published Cell's 'garbage disposal' may have another role: Helping neurons near skin sense the environment



The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but researchers, studying nerve cells grown in the lab and mice, say that the proteasome's role may go well beyond that.
Published How seaweed became multicellular



A deep dive into macroalgae genetics has uncovered the genetic underpinnings that enabled macroalgae, or 'seaweed,' to evolve multicellularity. Three lineages of macroalgae developed multicellularity independently and during very different time periods by acquiring genes that enable cell adhesion, extracellular matrix formation, and cell differentiation, researchers report. Surprisingly, many of these multicellular-enabling genes had viral origins. The study, which increased the total number of sequenced macroalgal genomes from 14 to 124, is the first to investigate macroalgal evolution through the lens of genomics.
Published Microbial food as a strategy food production of the future



Scientists have summarized microbial food production strategies.
Published Decoding the language of cells: Unveiling the proteins behind cellular organelle communication



A collaboration unveils a novel strategy for identifying key proteins in organelle communication. This approach advances our ability to pinpoint proteins essential for organelle interactions within specific spatial and temporal contexts.
Published Innovative antiviral defense with new CRISPR tool



The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.
Published Researchers identify new genetic risk factors for persistent HPV infections



Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide. While the immune system usually clears HPV infections, those that persist can lead to cancer, and a new finding suggests that certain women may have a genetic susceptibility for persistent or frequent HPV infections. These genetic variants could raise a woman's risk of getting cervical cancer from a high-risk HPV infection.
Published First step to untangle DNA: Supercoiled DNA captures gyrase like a lasso ropes cattle



Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications. Gyrases are biomedical targets for the treatment of bacterial infections and the similar human versions of the enzymes are targets for many anti-cancer drugs. Better understanding of how gyrases work at the molecular level can potentially improve clinical treatments.
Published Brainless memory makes the spinal cord smarter than previously thought



Researchers have discovered the neural circuitry in the spinal cord that allows brain-independent motor learning. The study found two critical groups of spinal cord neurons, one necessary for new adaptive learning, and another for recalling adaptations once they have been learned. The findings could help scientists develop ways to assist motor recovery after spinal cord injury.
Published New approach for combating 'resting' bacteria



Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick. But just as dangerous as this rapid growth can be a bacterium's resting state, which helps the pathogen evade antibiotics and contributes to severe chronic infections in the lungs and blood, within wounds, and on the surfaces of medical devices. Now, scientists have discovered how long chains of molecules called polyphosphates (polyP) are needed for bacteria to slow down movements within cells and let them enter this resting state.
Published Tropical coral-infecting parasites discovered in cold marine ecosystems



Parasites thought only to infect tropical coral reefs have been discovered in a large variety of creatures in cold marine ecosystems along the Northeast Pacific, according to new research.
Published Method to extract useful proteins from beer-brewing leftovers



Researchers have created a method that extracts over 80 percent of the available protein in grain leftovers from brewing beer, commonly known as brewers' spent grain.
Published Genetic underpinnings of environmental stress identified in model plant



Researchers have identified 14 genes that thale cress -- a plant commonly used in genetic investigations since its genome is well documented -- express more when responding to five specific stressors, as well as eight genes that the plant suppresses.
Published Geobiology: New placozoan habitat discovered



Traces of DNA in the stomachs of predatory snails give a team og geobiologists new insights into the ecology of placozoans.
Published New drug prevents flu-related inflammation and lung damage



Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.
Published The genesis of our cellular skeleton, image by image



Cells contain various specialized structures -- such as the nucleus, mitochondria or peroxisomes -- known as 'organelles'. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction.
Published Researchers discover how we perceive bitter taste



A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.
Published A new coating method in mRNA engineering points the way to advanced therapies



Researchers have developed a novel method of adding polyethylene glycol molecules to engineered groups of messenger RNAs called 'mRNA polyplexes', which enable the cells that receive them to produce specific proteins. This technique allows greater control of the site in the body to which the polyplexes are delivered, significantly advancing the field of therapeutic mRNA technologies, with applications in vaccine development and the treatment of cancer and other diseases.
Published Cockayne syndrome: New insights into cellular DNA repair mechanism



Researchers decode repair mechanism during transcription of genetic information.
Published A microbial plastic factory for high-quality green plastic



Engineered bacteria can produce a plastic modifier that makes renewably sourced plastic more processable, more fracture resistant and highly biodegradable even in sea water. The development provides a platform for the industrial-scale, tunable production of a material that holds great potential for turning the plastic industry green.
Published Machine learning method reveals chromosome locations in individual cell nucleus



Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.