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Categories: Biology: Evolutionary, Biology: Molecular

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A new technique to clone and reassemble DNA, dubbed CReATiNG, could simplify and lower the cost to make synthetic chromosomes. Potential applications are numerous, including pharmaceutical production, biofuel generation, cancer therapies, and environmental cleanup using modified organisms. The method adds a powerful, versatile tool to the burgeoning field of synthetic biology.

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Scientists have discovered that plants send tiny, innocuous-seeming lipid 'bubbles' filled with RNA across enemy lines, into the cells of the aggressive mold. Once inside, different types of RNA come out to suppress the infectious cells that sucked them in.

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Researchers describe unusual trilobite fossils prepared as thin sections showing the 3D soft tissues during enrollment. The study reveals the soft undersides of enrolled trilobites and the evolutionary mechanism that allows arthropods to enroll their bodies for protection from predators and adverse environmental conditions.

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Researchers have studied the relationships between five closely related species of larks that occur in Africa south of the Sahara. Two of these have not been observed for decades, so the researchers analyzed DNA from museum specimens, some of which were over 100 years old.

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A research team has uncovered a previously undetected mechanism in mice -- starring the genetic molecule RNA -- that could explain how each sensory cell, or neuron, in mammalian noses becomes tailored to detect a specific odor chemical.

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The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists have recently uncovered a fascinating aspect of this process known as 'replication timing' (RT) and how special this is when life commences.

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Researchers discover a new mechanism controlling the uptake of lipids from digested food.

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Aquaporin (Aqp) 10 water channels in humans allow the free passage of water, glycerol, urea, and boric acid across cells. However, Aqp10.2b in pufferfishes allows only the passage of water and glycerol and not urea and boric acid. Researchers sought to understand the evolutionary timeline that resulted in the variable substrate selection mechanisms among Aqp10s. Their results indicate that Aqp10.2 in ray-finned fishes may have reduced or lost urea and boric acid permeabilities through evolution.

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Nearly every organism on Earth follows a natural circadian rhythm that is coded by your cell's clock genes, which do exactly as you suspect from the name: regulate your body's rhythm on a 24-hour basis. Most cells in mammalian bodies have cilia of some sort, which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act as a sensory organ for the cell, a function which has illuminated the primary cilia's potential role in the healing process and how bodies heal at a different rate according to our circadian rhythm. In this research, the role of the primary cilia, biological clock and wound healing is explored.

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A newly identified protein helps poison dart frogs accumulate and store a potent toxin in their skin which they use for self-defence against predators.

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Almost all eukaryotic organisms, from plants and animals to fungi, can't survive without mitochondria -- the 'powerhouses of the cell,' which generate chemical energy using oxygen. However, a new study finds that multiple members of the oxymonads, a group of single-celled protists that live inside the guts of termites and other animals, have evolved to live quite happily without them.

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Wild North American grapes are now less of a mystery after researchers decoded and catalogued the genetic diversity of nine species of this valuable wine crop.

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Plants often develop communities with microorganisms in their roots, which influences plant health and development. Although the recruitment of these microbes is dictated by several factors, it is unclear whether the genetic variation in the host plants plays a role.

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A new study has demonstrate that the ingestion of two of the most commercially available algal species are rich in protein which supports muscle remodeling in young healthy adults. Their findings suggest that algae may be an interesting and sustainable alternative to animal-derived protein with respect to maintaining and building muscle.

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Scientists recently published findings indicating that Ebola virus creates and uses intercellular tunnels to move from cell to cell and evade treatments.

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Researchers have published an atlas of zebrafish development, detailing the gene expression programs that are activated within nearly every cell type during the first five days of development, a period in which embryos mature from a single cell into distinct cell types.

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Using optogenetics, researchers have detected a new acid sensor in plant cells that is addressing a cell-internal calcium store.  

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An international team of scientists led by geneticists and disease biologists has used ancient DNA to trace the evolution of Marek's Disease Virus (MDV). This global pathogen causes fatal infections in unvaccinated chickens and costs the poultry industry over $1 billion per year. The findings show how viruses evolve to become more virulent and could lead to the development of better ways to treat viral infections.

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An effective HIV vaccine may need to prompt strong responses from immune cells called CD8+ T cells to protect people from acquiring HIV, according to a new study. The study findings draw comparisons between the immune system activity of past HIV vaccine study participants and people with HIV who naturally keep the virus from replicating even in the absence of antiretroviral therapy (ART). The latter individuals are often called 'long-term non-progressors' or 'elite controllers' (LTNPs/ECs).

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Researchers have developed a theoretical framework that can reproduce and predict the patterns associated with gastrulation in a chicken embryo.