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Categories: Biology: Evolutionary, Biology: Molecular
Published Multiple evolutionary trajectories in aquatic crocodiles



In the geological past, several groups of crocodiles evolved towards a morphology adapted to marine life. However, the extent of these adaptations and their evolutionary trajectories remained unknown. An exhaustive study of their morphology has now shed light on the evolutionary mechanisms at work, thanks to three-dimensional reconstructions.
Published Colliding ribosomes activate RNA repair



Researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage.
Published Novel C. diff structures are required for infection, offer new therapeutic targets



Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles.
Published Previously unknown luminescence revealed in ten deep sea species and an order of sea cucumbers



Researchers present evidence of previously unknown luminosity in 10 deep-sea species, suggesting underestimated diversity. These new discoveries include a member of the order Molpadia, which was previously thought not to be luminescent. The authors stress the importance of considering the ecological role of bioluminesence and the need for conservation.
Published A tale of two proteins: Fundamental research could make growing better crops like clockwork



Rhomboid-like protein 10, or RBL10, is thought to be an enzyme that degrades other proteins in the chloroplast membrane, but its function is largely unknown. Researchers are studying how RBL10 affects photosynthetic membrane lipid metabolism, an essential process in photosynthesis.
Published Evolution of taste: Early sharks were able to perceive bitter substances



New genetic data show that humans and sharks share bitter taste receptors, even though their evolutionary pathways separated nearly 500 million years ago.
Published New discovery on how green algae count cell divisions illuminates key step needed for the evolution of multicellular life



An international research team has made an unexpected discovery of a biased counting mechanism used by the single-celled green alga Chlamydomonas to control cell division.
Published How marine bristle worms use a special protein to distinguish between sunlight and moonlight



A research team has presented its findings on the functioning of an atypical cryptochrome protein (Cry). These proteins are found in a variety of organisms, and they are often involved in light-controlled biological processes. The marine bristle worm Platynereis dumerilii, for example, employs a special Cry protein designated L-Cry to distinguish between sunlight and moonlight as well as between different moon phases. This is essential for the worms to synchronize their reproduction to the full moon phase via an inner monthly calendar, also called circalunar clock.
Published Ground-breaking discovery could pave the way for new therapies to prevent cardiovascular disease and stroke



Researchers have discovered the mechanism by which cholesterol in our diet is absorbed into our cells. This discovery opens up new opportunities for therapeutic intervention to control cholesterol uptake that could complement other therapies and potentially save lives.
Published The Goldilocks Effect: Researchers establish framework for protein regulation



Researchers are working to understand how protein quality control works in cells.
Published New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells



Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process. Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells.
Published The mystery of phosphite -- a scientific detective story



Biologists have discovered a phosphorus-based bacterial metabolism that is both new and ancient. In a special role: a calculation from the 1980s, a sewage plant, a new bacterial organism, and a remnant from around 2.5 billion years ago.
Published Yeast cells can produce drugs for treatment of psychotic disorders



An international team of researchers has demonstrated that genetically engineered yeast cells can produce the natural plant product alstonine, which has shown positive effects in treating schizophrenia.
Published Team creates synthetic enzymes to unravel molecular mysteries



A bioengineer has developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in the development of muscle, bone and blood in vertebrate embryos. The team of researchers is using a new approach, called the Synthetic Processing (SynPro) system, in zebrafish to study how Vg1 is formed. By learning the molecular rules of signal formation in a developing animal, researchers aim to engineer mechanisms -- such as giving cells new instructions -- that could play a role in treating or preventing disease.
Published Scientists use quantum biology, AI to sharpen genome editing tool



Scientists used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
Published Bacteria-virus arms race provides rare window into rapid and complex evolution



Rather than a slow, gradual process as Darwin envisioned, biologists can now see how evolutionary changes unfold on much more accelerated timescales. Using an accelerated arms race between bacteria and viruses, researchers are documenting rapid evolutionary processes in simple laboratory flasks in only three weeks.
Published Poison dart frogs: Personality determines reproductive strategies



Unlike their relatives, individuals of the poison frog Allobates femoralis are not poisonous but are captivating due to their different behavioral profiles: They successfully reproduce with different strategies depending on whether they are bold, aggressive or explorative. In addition, certain character traits are already present in this species at the tadpole stage.
Published First live birth of a chimeric monkey using embryonic stem cell lines



A team of researchers has reported for the first time the live birth of a monkey that contains a high proportion of cells derived from a monkey stem cell line. This 'chimeric' monkey is composed of cells that originate from two genetically distinct embryos of the same species of monkey. This has previously been demonstrated in rats and mice but, until now, has not been possible in other species, including non-human primates.
Published Zen and the art of mitochondrial maintenance: The machinery of death makes a healthier life



While we all aspire for a long lifespan, what is most coveted is a long period of vigor and health, or 'healthspan,' that precedes the inevitable decline of advancing age. Researchers have discovered that instruments of death that cells use to commit suicide when things go wrong contribute to making a longer and healthier life by revitalizing the specialized cellular compartments called mitochondria.
Published Temperature increase triggers viral infection



Researchers have mapped on an atomic level what happens in a virus particle when the temperature is raised.