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Categories: Biology: Molecular, Environmental: Biodiversity

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Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases. This has led to a growing demand for selective, efficient, and safe ways of delivering siRNA in cells. Now, in a cooperation between the Universities of Amsterdam and Leiden, researchers have developed dedicated molecular nanocages for siRNA delivery. In a paper just out in the Journal Chem they present nanocages that are easy to prepare and display tuneable siRNA delivery characteristics.

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A new global survey of 1000 forest areas shows how climate change since the peak of the last ice age has had a major impact on the diversity and distribution of tree species we see today. The results can help us predict how ecosystems will react to future changes, thus having an impact on conservation management around the globe.

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Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail. This technology has potential uses in tissue engineering, regenerative medicine, and understanding how the body works. The scientists applied their new method to control the glow of a green fluorescent protein derived from Japanese eel muscle.

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The diverse swimming techniques of the ancient reptiles that ruled the Mesozoic seas have been revealed.

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Researchers have discovered how long ago the Australian Nullarbor plain dried out, with a new approach shedding light on how ancient climate change altered some of the driest regions of our planet.

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Scientists have discovered extensive, ancient deep-sea coral reefs within the Galápagos Marine Reserve (GMR) -- the first of their kind ever to be documented inside the marine protected area (MPA) since it was established in 1998. The first reef observed was found at 400-600m (1,310-1,970 feet) depth at the summit of a previously unmapped seamount in the central part of the archipelago and supports a breathtaking mix of deep marine life.

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A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study now shows how two molecular mechanisms can work together make the bacterium extra resistant.

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Research has traced the evolutionary adaptations of octopus and squid sensing capabilities. The researchers describe for the first time the structure of an octopus chemotactile receptor, which octopus arms use for taste-by-touch exploration of the seafloor.

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Researchers describe how the Epstein-Barr virus exploits genomic weaknesses to cause cancer while reducing the body's ability to suppress it.

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Origin-of-life chemists propose that glyoxylate could have been the original source of sugars on the 'prebiotic' Earth

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Wildfires. Many see them as purely destructive forces, disasters that blaze through a landscape, charring everything in their paths. But a new study reminds us that wildfires are also generative forces, spurring biodiversity in their wakes.

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A research team has recently made a significant discovery about the evolutionary age of different type of cells in a small animal called Caenorhabditis elegans (C. elegans). By using single-cell transcriptomic data and refined phylostratigraphy, the team determines the transcriptomic age of individual cells, which means they are able to estimate the evolutionary origin of different cells based on the age of the genes expressed in the cells.

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In a series of experiments, a team of researchers have compared de novo proteins with random-sequence proteins, looking at their stability and solubility. The results are set to advance basic research in this new field.

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Acylceramides and protein-bound ceramides are vital for the formation of the oral barrier in mice, similar to their role in skin, protecting from infection.

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Scientists have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers. With dietary restrictions, these processes could be reversed.

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A study of Britain's native flowering plants has led to new insights into the mysterious process that allows wild plants to breed across species -- one of plants' most powerful evolutionary forces.  When wild flowering plants are sizing up others they may often end up in a marriage between close relatives rather than neighbors, a new study has revealed.

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The island of Dominica took a direct hit from Category 5 Hurricane Maria. Nine months afterward, researchers found that while 89% percent of trees located in nine previously documented forest stands were damaged, but only 10 percent had immediately died. The most common damage was stem snapping and major branch damage. The damage with the highest rates of mortality were uprooting and being crushed by a neighboring tree. Large individual trees and species with lower wood density were susceptible to snapping, uprooting and mortality. Those on steeper slopes were more prone to being crushed by neighboring trees.

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Researchers discovered that males of the yellow crazy ant have maternal and paternal genomes in different cells of their body and are thus chimeras.

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Important species often get overlooked if they lack flashy colors or charismatic behavior. This is true of euptychiine butterflies, one of the most common insects in the Amazon Rainforest that have been largely ignored by scientists and naturalists throughout the 20th century. A new study pieces together the natural history of the group, in which males can look so unlike females, they've been repeatedly mistaken for separate species, diversity has been drastically underestimated, and more than 100 unnamed species are waiting on scientific description.

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An interdisciplinary team of researchers is advocating for convergent research that integrates the fields of biogeography and behavioral ecology to more rapidly respond to challenges associated with climate change and biodiversity loss.