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Categories: Biology: Molecular, Environmental: Biodiversity
Published Slugs and snails love the city, unlike other animals
(via sciencedaily.com) Original source Most native species avoid more urbanized areas of Los Angeles, but slugs and snails may actually prefer these environments, according to a new study.
Published Wild megalopolis: Study shows unexpected pockets of biodiversity pepper Los Angeles
(via sciencedaily.com) Original source Researchers, in partnership with the city of Los Angeles, have developed the urban association index to help identify how well or poorly individual wildlife species are doing in the city. The researchers found unexpected pockets of biodiversity deep in the city, but they say it will still be a challenge to elevate Los Angeles' overall level of biodiversity.
Published Marine Protected Areas don't line up with core habitats of rare migratory fish, finds new research
(via sciencedaily.com) Original source 62% of Marine Protected Areas (MPAs) designated to protect rare migratory fish species are outside of their core habitats, according to a new modeling study.
Published Intermittent fasting shows promise in improving gut health, weight management
(via sciencedaily.com) Original source Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction. The findings could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.
Published Smarter foragers do not forage smarter
(via sciencedaily.com) Original source Why do primates have big brains? In the Panamanian rainforest, scientists pitted large-brained primates against smaller-brained mammals to find out who was the smartest forager.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'Cloaked' proteins deliver cancer-killing therapeutics into cells
(via sciencedaily.com) Original source Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Global activity of seafloor biodiversity mapped
(via sciencedaily.com) Original source A team of scientists has used artificial intelligence (AI) to map the activities of seafloor invertebrate animals, such as worms, clams and shrimps, across all the oceans of the world.
Published Observing mammalian cells with superfast soft X-rays
(via sciencedaily.com) Original source Researchers have developed a new technique to view living mammalian cells. The team used a powerful laser, called a soft X-ray free electron laser, to emit ultrafast pulses of illumination at the speed of femtoseconds, or quadrillionths of a second. With this they could capture images of carbon-based structures in living cells for the first time, before the soft X-ray radiation damaged them.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development
(via sciencedaily.com) Original source Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Novel approach to interrogate tissue-specific protein-protein interactions
(via sciencedaily.com) Original source Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published Tracking down the genetic causes of lupus to personalize treatment
(via sciencedaily.com) Original source Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.
Published Exploring diversity in cell division
(via sciencedaily.com) Original source Animals and fungi predominantly use two different modes of cell division -- called open and closed mitosis, respectively. A new study has shown that different species of Ichthyosporea -- marine protists that are close relatives of both animals and fungi -- use either open and closed mitosis, closely correlated to whether the species has multinucleate life cycle stages. The study demonstrates the way animals do cell division might have evolved long before animals themselves did and how this is linked to an organism's life cycle.
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published Conservation of nature's strongholds needed to halt biodiversity loss
(via sciencedaily.com) Original source To achieve global biodiversity targets, conservationists and governments must prioritize the establishment and effective management of large, interconnected protected areas with high ecological integrity, researchers argue in a new essay.
Published Regional differences in bird diversity in agroforestry systems
(via sciencedaily.com) Original source The diversity and ecological functionality of bird communities in tropical agroforestry systems are shaped by the surrounding landscape, in particular the extent and composition of the forest.
Published Improving statistical methods to protect wildlife populations
(via sciencedaily.com) Original source In human populations, it is relatively easy to calculate demographic trends and make projections of the future if data on basic processes such as births and immigration is known. The data, given by individuals, can be also death and emigration, which subtract. In the wild, on the other hand, understanding the processes that determine wildlife demographic patterns is a highly complex challenge for the scientific community. Although a wide range of methods are now available to estimate births and deaths in wildlife, quantifying emigration and immigration has historically been difficult or impossible in many populations of interest, particularly in the case of threatened species.
Published Studies reveal cell-by-cell changes caused when pig hearts and kidneys are transplanted into humans
(via sciencedaily.com) Original source Two new studies detail the changes seen at the single-cell level in pig organs and recipient human bodies before, during, and just after the xenotransplantation surgeries in the decedents.
Published Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
(via sciencedaily.com) Original source Although periodontitis is an extremely prevalent disorder, it is challenging to conduct detailed and comprehensive analyses of its progression at the cellular level. Recently, researchers developed an improved periodontitis mouse model that simplifies the collection and analysis of multiple periodontal tissue types. Using this model, they clarified the role of an important signaling pathway in the inflammatory response of periodontal tissue, paving the way for better diagnostic and therapeutic strategies for periodontitis.