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Categories: Biology: Molecular, Environmental: Biodiversity
Published Genome editing: Reducing off-target mutations in DNA
(via sciencedaily.com) Original source Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.
Published Genetically modified bacteria break down plastics in saltwater
(via sciencedaily.com) Original source Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.
Published Researchers discover tissue-specific protection against protein aggregation
(via sciencedaily.com) Original source Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.
Published Rivers are rapidly warming, losing oxygen; aquatic life at risk
(via sciencedaily.com) Original source Rivers are warming and losing oxygen faster than oceans, according to a new article. The study shows that of nearly 800 rivers, warming occurred in 87% and oxygen loss occurred in 70%.
Published Pollination by more than one bee species improves cherry harvest
(via sciencedaily.com) Original source To obtain the biggest cherry harvest, trees should be pollinated by both honey bees and mason bees. This new study shows yet another benefit of biodiversity.
Published From hagfish to membrane: Modeling age-related macular degeneration
(via sciencedaily.com) Original source Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.
Published Earth's stability and ability to support civilization at risk: Six of nine planetary boundaries exceeded
(via sciencedaily.com) Original source A new study updates the planetary boundary framework and shows human activities are increasingly impacting the planet and, thereby, increasing the risk of triggering dramatic changes in overall Earth conditions.
Published Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
(via sciencedaily.com) Original source During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.
Published Mysterious family of microbial proteins hijack crops' cellular plumbing
(via sciencedaily.com) Original source Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.
Published A protein on cancer cells supports the immune response against tumors
(via sciencedaily.com) Original source Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation of T cells, thus improving the immune response against the tumor.
Published Protected nature reserves alone are insufficient for reversing biodiversity loss
(via sciencedaily.com) Original source Protected nature areas are considered fundamental for maintaining biodiversity and countering its loss. But how effectively do established protected areas work and prevent negative trends? Research shows mixed effects of protected areas on various species.
Published Some spiders can transfer mercury contamination to land animals
(via sciencedaily.com) Sitting calmly in their webs, many spiders wait for prey to come to them. Arachnids along lakes and rivers eat aquatic insects, such as dragonflies. But, when these insects live in mercury-contaminated waterways, they can pass the metal along to the spiders that feed on them. Now, researchers have demonstrated how some shoreline spiders can move mercury contamination from riverbeds up the food chain to land animals.
Published More Texas owls are testing positive for rat poisons
(via sciencedaily.com) New research suggests that owls in Texas have high rates of anticoagulant rodenticides (AR) -- blood thinning rat poisons -- in their systems.
Published 'Dormant' HIV produces RNA and proteins during anti-retroviral therapy
(via sciencedaily.com) Original source HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.
Published Freshwater connectivity can transport environmental DNA through the landscape
(via sciencedaily.com) A new article uses environmental DNA (eDNA) metabarcoding to analyze fish and zooplankton communities. The study found that the movement of water between freshwater bodies, or freshwater connectivity, can transport eDNA. This highlights the potential of eDNA to provide a comprehensive view of freshwater biodiversity.
Published Comprehensive insulin signalling map shows interplay between genes and diet
(via sciencedaily.com) Original source Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.
Published Plant-based food alternatives could support a shift to global sustainability
(via sciencedaily.com) Replacing 50% of meat and milk products with plant-based alternatives by 2050 can reduce agriculture and land use related greenhouse gas (GHG) emissions by 31% and halt the degradation of forest and natural land, according to new research.
Published Super antifreeze in cells: The ability to survive in ice and snow developed in animals far earlier than we thought
(via sciencedaily.com) Original source More than 400 million years ago, an insect-like animal called the springtail developed a small protein that prevents its cells from freezing.
Published Researcher helps boost immune system memory against influenza
(via sciencedaily.com) Original source Researchers are one step closer to making the T cell army stronger. In a recent study, researchers found that by manipulating one molecular signaling pathway in the T cells that participate in clearing influenza virus in the lungs, the strength and longevity of immunological memory produced can be improved.
Published Auxin signaling pathway controls root hair formation for nitrogen uptake
(via sciencedaily.com) Original source Root hairs represent a low-cost strategy to enhance nutrient uptake because they can significantly increase the nutrient-acquiring surface of plant roots. While primary and lateral roots are stimulated to elongate when plants grow under mild nitrogen deficiency, the existence of such a foraging response for root hairs and its underlying regulatory mechanism remain elusive. Now, researchers have revealed a framework composed of specific molecular players meditating auxin synthesis, transport and signaling that triggers root hair elongation for nitrogen acquisition.