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Categories: Biology: Molecular, Geoscience: Oceanography

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Study reveals how drug molecules bind in channels between neighboring cells, changing intercellular communication.

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Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles -- structures that transport waste or food within cells. In a recent paper, researchers shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.

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Colossal undersea mountains, towering up to thousands of metres high, stir up deep sea currents: impacting how our ocean stores heat and carbon. An international team used numerical modelling to quantify how underwater turbulence around these mountains, called seamounts, influences ocean circulation; finding it is an important mechanism in ocean mixing and one that is missing from climate models used in policymaking.

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New research describes how nerve cells and muscle cells communicate through electrical signals during development -- a phenomenon known as bioelectricity. The communication, which takes place via specialized channels between cells, is vital for proper development and behavior. The study identifies specific genes that control the process, and pins down what happens when it goes wrong. The finding offers clues to the genetic origins of muscle disorders in humans.

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The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.

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Research shows that the increasingly popular weight-loss strategy is safe. Intermittent fasting has become an increasingly popular way to lose weight without counting calories. And a large body of research has shown it s safe. Still, several myths about fasting have gained traction.

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Researchers have discovered a salt adaptation mechanism in plants that facilitates chloride removal from the roots and enhancing salinity tolerance. A research team has uncovered a novel mechanism of plant adaptation to salt stress involving the NaCl-induced translocation of a specific chloride channel protein, AtCLCf.

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The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.

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Much of the methane released into the southern Baltic Sea from the Nord Stream gas pipeline has remained in the water. This is shown by measurements taken by researchers from the University of Gothenburg.

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An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

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Archipelago case-study shows that removing invasive rats and restoring native vegetation could help bring back hundreds of thousands of breeding pairs of seabirds lost to tropical islands. Calculating that there are enough fish to sustain restored seabird populations should be an important consideration for restoration projects, scientists say. Restored seabird populations also provide huge boost to the health of surrounding coral reef ecosystems through restored nutrient cycles.

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Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.

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The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice. While uncovering how the high fat, low carbohydrate diet boosts memory in older mice, scientists identified a new molecular signaling pathway that improves synapse function and helps explain the diet's benefit on brain health and aging.

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Detecting marine debris from space is now a reality, according to a new study. Until now, the amount of litter -- mostly plastic -- on the sea surface was rarely high enough to generate a detectable signal from space. However, using supercomputers and advanced search algorithms, the research team has demonstrated that satellites are an effective tool for estimating the amount of litter in the sea.

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In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.

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Thirty-by-thirty: protect 30% of the planet by 2030. While conservation is popular in principle, the costs of actually enacting it often stall even the most earnest efforts. Researchers have now proposed a market-based approach to achieving the 30x30 targets in the ocean.

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The understanding of the global zinc cycle in our oceans has important implications in the context of warming oceans. A warmer climate increases erosion, leading to more dust in the atmosphere and consequently more dust being deposited into the oceans. More dust means more scavenging of zinc particles, leading to less zinc being available to sustain phytoplankton and other marine life, thereby diminishing the oceans' ability to absorb carbon.

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When it comes to the ocean's response to global warming, we're not in entirely uncharted waters. A new study shows that episodes of extreme heat in Earth's past caused the exchange of waters from the surface to the deep ocean to decline.

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Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.

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Deposits of deep-pink sand washing up on South Australian shores shed new light on when the Australian tectonic plate began to subduct beneath the Pacific plate, as well as the presence of previously unknown ancient Antarctic mountains.