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Categories: Anthropology: General, Biology: Molecular
Published Peering inside cells to see how they respond to stress
(via sciencedaily.com) Original source The heat shock response of cells is a classic model of biological adaptation, part of the fundamental processes of life -- conserved in creatures from single-celled yeast to humans -- that allow our cells to adjust to changing conditions in their environment. For years, scientists have focused on how different genes respond to heat stress to understand this survival technique. Now, thanks to the innovative use of advanced imaging techniques, researchers are getting an unprecedented look at the inner machinery of cells to see how they respond to heat stress.
Published Climate change coping mechanism discovered in humble algae
(via sciencedaily.com) Original source One of the building blocks of ocean life can adapt to cope with the effects of climate change, according to new research. The discovery holds promises for biotechnology developments that could counter the negative effects of changing environmental conditions, such as ocean warming and even the reduction in the productivity of crops.
Published Fecal microbe transplants: B. vulgatus genes that correlate with early colonization
(via sciencedaily.com) Original source Fecal microbe transplants from healthy donors can treat patients with recurrent Clostridium difficile infections. However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant. Most failures of fecal microbe transplantation occur in the first four weeks. Researchers have now found 19 Bacteroides vulgatus genes that were unique to three strains that show early engraftment in patients after a fecal transplant, as opposed to seven strains that did not show early engraftment.
Published Win-win in muscle research: Faster results and fewer laboratory animals thanks to new method
(via sciencedaily.com) Original source To study muscle diseases, scientists rely on the mouse as a model organism. Researchers have now developed a new method that is not only faster and more efficient than conventional ones but also greatly reduces the number of experimental animals needed for studying the function of genes in muscle fibers.
Published Omega-3 discovery moves us closer to 'precision nutrition' for better health
(via sciencedaily.com) Original source Researchers have obtained new insights into how African-American and Hispanic-American people’s genes influence their ability to use Omega-3 and Omega-6 fatty acids for good health. The findings are an important step toward “precision nutrition” – where a diet tailored to exactly what our bodies need can help us live longer, healthier lives.
Published Evolutionary secrets of 'Old Tom' and the killer whales of Eden revealed by genetic study
(via sciencedaily.com) Original source Evolutionary biologists have for the first time decoded the genetic lineage of a famous killer whale and a pod that once worked alongside whale hunters off the coast of Australia. In the Australian tradition of claiming New Zealand's celebrities as its own, Old Tom, the leader of a pod of killer whales that famously helped whalers hunt baleen whales in the 20th century, has ancestral links to modern-day killer whales in New Zealand, according to new DNA research. Old Tom also shared a common ancestor with killer whales from Australasia, the North Pacific, and North Atlantic Oceans, but is most similar to modern New Zealand killer whales. However, most of Tom's DNA code is not found in other killer whales globally suggesting that the killer whales of Eden may have become extinct locally.
Published Neanderthal gene variants associated with greater pain sensitivity
(via sciencedaily.com) Original source People who carry three gene variants that have been inherited from Neanderthals are more sensitive to some types of pain, according to a new study.
Published Evidence from the remains of 1918 flu pandemic victims contradicts long-held belief that healthy young adults were particularly vulnerable
(via sciencedaily.com) Original source New analysis of the remains of victims of the 1918 influenza pandemic, which killed an estimated 50 million people worldwide, contradicts the widespread belief the flu disproportionately impacted healthy young adults.
Published Newfound mechanism suggests drug combination could starve pancreatic cancer
(via sciencedaily.com) Original source A study found that a new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for fuel.
Published Epigenetic regulator MOF drives mitochondrial metabolism
(via sciencedaily.com) Original source Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17. Cells lacking MOF-mediated COX17 acetylation exhibit dramatic mitochondrial defects and impaired ability to produce energy. Underscoring the clinical relevance of these findings, the team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF.
Published How male mosquitoes compensate for having only one X chromosome
(via sciencedaily.com) Researchers have discovered the master regulator responsible for balancing the expression of X chromosome genes between males and females in the malaria mosquito. This discovery helps scientists better understand the evolution of the epigenetic mechanisms responsible for equalizing gene expression between the sexes. The findings may contribute to the development of new ways to prevent the spread of malaria.
Published New discovery may 'unlock' the future of infectious disease and cancer treatment
(via sciencedaily.com) Original source Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.
Published The end of genes: Routine test reveals unique divergence in genetic code
(via sciencedaily.com) Original source Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics. The genome of a protist has revealed a seemingly unique divergence in the DNA code signalling the end of a gene, suggesting the need for further research to better understand this group of diverse organisms.
Published New open-source method to improve decoding of single-cell data
(via sciencedaily.com) Original source Researchers have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data. By guiding data analysis in a unique way, Spectra can offer new insights into the complex interplay between cells — like the interactions between cancer cells and immune cells, which are critical to improving immunotherapy treatments.
Published Early human migrants followed lush corridor-route out of Africa
(via sciencedaily.com) Original source Scientists have found early human migrants left Africa for Eurasia, across the Sinai peninsula and on through Jordan, over 80-thousand years ago. Researchers have proved there was a 'well-watered corridor' which funneled hunter-gatherers through The Levant towards western Asia and northern Arabia via Jordan.
Published Proteins roll the dice to determine bee sex
(via sciencedaily.com) Original source To date it has been unclear exactly how the sex of a bee is determined. A research team comprising biologists and chemists has now identified a key gene and the molecular mechanism linked with it. They describe how this process is similar to a game involving two dice.
Published Avatars to help tailor glioblastoma therapies
(via sciencedaily.com) Original source Scientists have created a new zebrafish xenograft platform to screen for novel treatments for an aggressive brain tumor called glioblastoma, according to a new study.
Published Honeybees are more selective in their choices for nutrition than previously thought
(via sciencedaily.com) Original source An international research group examined which plants honeybees favor when collecting nectar and pollen. The choices honeybees make have an impact on their health and also on humans, as honeybees pollinate important crop plants.
Published How new plant cell walls change their mechanical properties after cell division
(via sciencedaily.com) Original source Scientists reveal new plant cell walls can have significantly different mechanical properties compared to surrounding parental cell walls, enabling cells to change their local shape and influence the growth of plant organs.
Published DNA from discarded whale bones suggests loss of genetic diversity due to commercial whaling
(via sciencedaily.com) Original source Commercial whaling in the 20th century decimated populations of large whales but also appears to have had a lasting impact on the genetic diversity of today’s surviving whales, new research shows.