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Categories: Anthropology: Cultures, Biology: Molecular
Published AI can improve Alzheimer's treatment through the 'gut-brain axis'
(via sciencedaily.com) Original source Researchers are using artificial intelligence to uncover the link between the gut microbiome and Alzheimer's disease. Previous studies showed that Alzheimer's disease patients have changes in their gut bacteria as the disease develops. The study outlines a computational method to determine how bacterial byproducts called metabolites interact with receptors on cells and contribute to Alzheimer's disease.
Published Scientists discover the cellular functions of a family of proteins integral to inflammatory diseases
(via sciencedaily.com) Original source In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.
Published Protein network dynamics during cell division
(via sciencedaily.com) Original source An international team has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the cell cycle, which required a combination of deep learning and high-throughput microscopy.
Published The enemy within: How pathogens spread unrecognized in the body
(via sciencedaily.com) Original source Some pathogens hide inside human cells to enhance their survival. Researchers have uncovered a unique tactic certain bacteria use to spread in the body without being detected by the immune system. In their study, they reveal the crucial role of a bacterial nanomachine in this infection process.
Published Breakthrough rice bran nanoparticles show promise as affordable and targeted anticancer agent
(via sciencedaily.com) Original source Plant-derived nanoparticles have demonstrated significant anticancer effects. Researchers recently developed rice bran-derived nanoparticles (rbNPs) that efficiently suppressed cell proliferation and induced programmed cell death of only cancer cells. Furthermore, rbNPs successfully suppressed the growth of tumors in mice having aggressive adenocarcinoma in their peritoneal cavity, without any adverse effects. Given their low production costs and high efficacy, rbNPs hold great promise for developing affordable and safe anticancer agents.
Published Key protein regulates immune response to viruses in mammal cells
(via sciencedaily.com) Original source Researchers have revealed the regulatory mechanism of a specific protein, TRBP, that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development of antiviral therapies and nucleic acid medicines to treat genetic disorders.
Published Light show in living cells
(via sciencedaily.com) Original source Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.
Published Why can zebrafish regenerate damaged heart tissue, while other fish species cannot?
(via sciencedaily.com) Original source A heart attack will leave a permanent scar on a human heart, yet other animals, including zebrafish, can clear cardiac scar tissue and regrow damaged muscle as adults. Biologists sheds new light on how zebrafish heal heart tissue by comparing how this species responds to heart injury with medaka, a fish species that cannot regenerate cardiac tissue.
Published RNA's hidden potential: New study unveils its role in early life and future bioengineering
(via sciencedaily.com) Original source The origin of life continues to remain a matter of debate. The ribonucleic acid (RNA) world hypothesis proposes that 'ribozymes' which store genetic information and possess catalytic functions may have supported the activities of early life forms. Now, researchers explore how RNA elongation is regulated allosterically, shedding light on its impact on early life processes and offering insights into the fabrication of arbitrary RNA nanostructures with various modern applications.
Published First evidence of human occupation in lava tube cave in Saudi Arabia
(via sciencedaily.com) Original source New research has highlighted an area in Arabia that once acted as a key point for cultural exchanges and trades amongst ancient people -- and it all took place in vast caves and lava tubes that have remained largely untapped reservoirs of archaeological abundance in Arabia. Through meticulous excavation and analysis, the international team uncovered a wealth of evidence at Umm Jirsan, spanning from the Neolithic to the Chalcolithic/Bronze Age periods (~10,000-3,500 years ago).
Published Solving a mini mystery of cell division
(via sciencedaily.com) Original source Trying to hit a target size before dividing seems like the best strategy for maintaining a precise cell size, but bacteria don't do that. Now we know why.
Published Plant sensors could act as an early warning system for farmers
(via sciencedaily.com) Original source Using a pair of sensors made from carbon nanotubes, researchers discovered signals that help plants respond to stresses such as heat, light, or attack from insects or bacteria. Farmers could use these sensors to monitor threats to their crops, allowing them to intervene before the crops are lost.
Published Tracking a protein's fleeting shape changes
(via sciencedaily.com) Original source Researchers have developed a powerful, new technique to generate 'movies' of changing protein structures and speeds of up to 50 frames per second.
Published Researchers uncover human DNA repair by nuclear metamorphosis
(via sciencedaily.com) Original source Researchers have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.
Published How blue-green algae manipulate microorganisms
(via sciencedaily.com) Original source A research team discovers previously unknown gene that indirectly promotes photosynthesis Protein regulator NirP1 influences the coordination of the nitrogen and carbohydrate metabolism 'Such protein regulators could in future be deployed in 'green' and 'blue' biotechnology for targeted control of the metabolism,' says geneticist.
Published Unlocking the 'chain of worms'
(via sciencedaily.com) Original source An international team of scientists has published a single-cell atlas for Pristina leidyi (Pristina), the water nymph worm, a segmented annelid with extraordinary regenerative abilities that has fascinated biologists for more than a century.
Published Starving cells hijack protein transport stations
(via sciencedaily.com) Original source Study details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions.
Published Cell's 'garbage disposal' may have another role: Helping neurons near skin sense the environment
(via sciencedaily.com) Original source The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but researchers, studying nerve cells grown in the lab and mice, say that the proteasome's role may go well beyond that.
Published How seaweed became multicellular
(via sciencedaily.com) Original source A deep dive into macroalgae genetics has uncovered the genetic underpinnings that enabled macroalgae, or 'seaweed,' to evolve multicellularity. Three lineages of macroalgae developed multicellularity independently and during very different time periods by acquiring genes that enable cell adhesion, extracellular matrix formation, and cell differentiation, researchers report. Surprisingly, many of these multicellular-enabling genes had viral origins. The study, which increased the total number of sequenced macroalgal genomes from 14 to 124, is the first to investigate macroalgal evolution through the lens of genomics.
Published Microbial food as a strategy food production of the future
(via sciencedaily.com) Original source Scientists have summarized microbial food production strategies.