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Categories: Archaeology: General, Biology: Molecular
Published 3,500-year-old Mycenaean armor was suitable for extended battle
(via sciencedaily.com) Original source A 3,500-year-old suit of Mycenaean armour may have been used in battle -- and not just for ceremonial purposes as previously thought -- new research reveals.
Published Exploring diversity in cell division
(via sciencedaily.com) Original source Animals and fungi predominantly use two different modes of cell division -- called open and closed mitosis, respectively. A new study has shown that different species of Ichthyosporea -- marine protists that are close relatives of both animals and fungi -- use either open and closed mitosis, closely correlated to whether the species has multinucleate life cycle stages. The study demonstrates the way animals do cell division might have evolved long before animals themselves did and how this is linked to an organism's life cycle.
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published Excavation reveals 'major' ancient migration to Timor Island
(via sciencedaily.com) Original source The discovery of thousands of stone artefacts and animal bones in a deep cave in Timor Island has led archaeologists to reassess the route that early humans took to reach Australia. Researchers dated and analysed the artefacts and sediment at the Laili rock shelter in central-north Timor-Leste, north of Australia, to pinpoint the arrival of the colonists.
Published Studies reveal cell-by-cell changes caused when pig hearts and kidneys are transplanted into humans
(via sciencedaily.com) Original source Two new studies detail the changes seen at the single-cell level in pig organs and recipient human bodies before, during, and just after the xenotransplantation surgeries in the decedents.
Published Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
(via sciencedaily.com) Original source Although periodontitis is an extremely prevalent disorder, it is challenging to conduct detailed and comprehensive analyses of its progression at the cellular level. Recently, researchers developed an improved periodontitis mouse model that simplifies the collection and analysis of multiple periodontal tissue types. Using this model, they clarified the role of an important signaling pathway in the inflammatory response of periodontal tissue, paving the way for better diagnostic and therapeutic strategies for periodontitis.
Published Modern plant enzyme partners with surprisingly ancient protein
(via sciencedaily.com) Original source Scientists have discovered that a protein responsible for the synthesis of a key plant material evolved much earlier than suspected. This new research explored the origin and evolution of the biochemical machinery that builds lignin, a structural component of plant cell walls with significant impacts on the clean energy industry.
Published Sweet taste receptor affects how glucose is handled metabolically by humans
(via sciencedaily.com) Original source The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption and assimilation, as part of this system. A team found that stimulation and inhibition of the sweet receptor helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes.
Published Scientists discover mechanism of sugar signaling in plants
(via sciencedaily.com) Original source A paper describes how the moving parts of a particular plant protein control whether plants can grow and make energy-intensive products such as oil -- or instead put in place a series of steps to conserve precious resources. The study focuses specifically on how the molecular machinery is regulated by a molecule that rises and falls with the level of sugar -- plants' main energy source.
Published Pagan-Christian trade networks supplied horses from overseas for the last horse sacrifices in Europe
(via sciencedaily.com) Original source Horses crossed the Baltic Sea in ships during the Late Viking Age and were sacrificed for funeral rituals. Studies on the remains of horses found at ancient burial sites in Russia and Lithuania show that they were brought overseas from Scandinavia utilizing expansive trade networks connecting the Viking world with the Byzantine and Arab Empires. Up to now, researchers had believed sacrificial horses were always locally-sourced stallions. But these results reveal horses from modern Sweden or Finland traveled up to 1,500 km across the Baltic Sea. The findings also show that the sex of the horse was not necessarily a factor in them being chosen for sacrifice, with genetic analysis showing one in three were mares.
Published Plants restrict use of 'Tipp-Ex proteins'
(via sciencedaily.com) Original source Plants have special corrective molecules at their disposal that can make retrospective modifications to copies of genes. However, it would appear that these 'Tipp-Ex proteins' do not have permission to work in all areas of the cell, only being used in chloroplasts and mitochondria. A study has now explained why this is the case. It suggests that the correction mechanism would otherwise modify copies that have nothing wrong with them, with fatal consequences for the cell.
Published Fruit fly wing research offers window into birth defects
(via sciencedaily.com) Original source If fruit fly wings do not develop into the right shape, the flies will die. Researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.
Published Early arrival and expansion of palaeolithic people on Cyprus
(via sciencedaily.com) Original source The patterns of dispersal of early humans across continents and islands are hotly debated, but researchers have found that Pleistocene hunter-gatherers settled in Cyprus thousands of years earlier than previously thought. In examining the timing of the first human occupation of Cyprus, research found that large islands in the Mediterranean Sea were attractive and favorable destinations for palaeolithic peoples. These findings refute previous studies that suggested Mediterranean islands would have been unreachable and inhospitable for Pleistocene hunter-gatherer societies.
Published A new 'rule of biology' may have come to light, expanding insight into evolution and aging
(via sciencedaily.com) Original source A molecular biologist may have found a new 'rule of biology.' The rule challenges long-held notions that most living organisms prefer stability over instability because stability requires less energy and fewer resources.
Published New sensor gives unprecedented look at changes in cell's energy 'currency'
(via sciencedaily.com) Original source A new sensor is giving researchers the best look yet at ATP levels inside living cells, enabling scientists to study in greater detail than ever before how fluctuations in this cellular currency affect the cell and contribute to disease.
Published Bioengineered enzyme creates natural vanillin from plants in one step
(via sciencedaily.com) Original source Vanilla, the most widely used flavoring compound in confectionaries and cosmetics, gets its sweet flavor and aroma from the chemical compound -- 'vanillin'. However, the large-scale production of natural vanillin is impeded by the lack of microbial processes and enzymes which can commercially generate vanillin. Now, researchers have genetically engineered a novel enzyme which can convert ferulic acid from plant waste into vanillin in a one-step sustainable process.
Published Heating proteins to body temperature reveals new drug targets
(via sciencedaily.com) Original source Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications. The findings could revolutionize wide swathes of biology by fundamentally changing how protein structure is studied and leveraged for drug design.
Published Now we know, what gets roots to grow: Can help in future droughts
(via sciencedaily.com) Original source A biological mechanism familiar to people who fast helps plant roots grow strong. The discovery provides an answer to a long-unanswered question and a deeper understanding of the 'mouths' of plants that can help to develop climate-resilient crops.
Published An active agent against hepatitis E
(via sciencedaily.com) Original source At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one. A team may have found what they're looking for. The researchers showed that the compound K11777 prevents host cells from helping the virus out of its shell by cleaving the viral capsid. This means it can no longer infect cells.
Published Exploring the mechanism behind drug eruptions in the skin
(via sciencedaily.com) Original source Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.