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Categories: Archaeology: General, Biology: Molecular
Published Scientists present evidence for a billion-years arms race between viruses and their hosts



Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.
Published Wiggly proteins guard the genome



Dynamic network in the pores of the nuclear envelope blocks dangerous invaders.
Published Do people and monkeys see colors the same way?



New findings in color vision research imply that humans can perceive a greater range of blue tones than monkeys do. Distinct connections found in the human retina may indicate recent evolutionary adaptations for sending enhanced color vision signals from the eye to the brain.
Published Previously unknown intercellular electricity may power biology



Researchers have discovered that the electrical fields and activity that exist through a cell's membrane also exist within and around another type of cellular structure called biological condensates. Like oil droplets floating in water, these structures exist because of differences in density. Their foundational discovery could change the way researchers think about biological chemistry. It could also provide a clue as to how the first life on Earth harnessed the energy needed to arise.
Published Artificial photosynthesis for environmentally friendly food production



Ensuring the supply of food to the constantly growing world population and protecting the environment at the same time are often conflicting objectives. Now researchers have successfully developed a method for the synthetic manufacture of a nutritional protein using a type of artificial photosynthesis. The animal feed industry is the primary driver of high demand for large volumes of this nutritional protein L-alanine, which is also suitable for use in meat substitute products.
Published Scientists identify antivirals that could combat emerging infectious diseases



A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.
Published Scientists slow aging by engineering longevity in cells



Researchers have developed a biosynthetic 'clock' that keeps cells from reaching normal levels of deterioration related to aging. They engineered a gene oscillator that switches between the two normal paths of aging, slowing cell degeneration and setting a record for life extension.
Published Pulling the plug on viral infections: CRISPR isn't just about cutting



CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses. A new study reveals a previously unrecognized player in one such system -- a membrane protein that enhances anti-viral defense. According to study authors, the finding upends the idea that CRISPR systems mount their defense only by degrading RNA and DNA in cells.
Published How dormant bacteria come back to life



Bacterial spores can survive for years, even centuries, without nutrients, resisting heat, UV radiation, and antibiotics. How inert, sleeping bacteria -- or spores -- spring back to life has been a century-long mystery. New research identifies how sensor proteins revive dormant bacteria. Discovery opens new routes to combat spore resistance to antibiotics and sterilization. Findings can inform novel strategies to prevent infections, food spoilage.
Published Prolonged droughts likely spelled the end for Indus megacities



New research has found evidence -- locked into an ancient stalagmite from a cave in the Himalayas -- of a series of severe and lengthy droughts which may have upturned the Bronze Age Indus Civilization.
Published Near-universal T cell immunity towards a broad range of bacteria



Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity. Scientists have discovered an exception to this rule. Namely, a group of divergent bacterial pathogens, including pneumococci, all share a small highly conserved protein sequence, which is both presented and recognized by human T cells in a conserved population-wide manner.
Published Luring the virus into a trap



Viruses like influenza A and Ebola invade human cells in a number of steps. Research teams investigated the final stages of viral penetration using electron tomography and computer simulations. So-called fusion pores, through which the viral genome is released into the host cell, play a central role in these processes. If they can be prevented from forming, the virus is also blocked. The Heidelberg scientists describe previously unknown mechanisms, which might lead to new approaches to prevent infections.
Published Searching for ancient bears in an Alaskan cave led to an important human discovery



Genetic analysis links 3,000-year-old bone found in cave to modern Alaska Natives.
Published Researchers reveal an ancient mechanism for wound repair



The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.
Published Researchers reveal a map to study novel form of cell-to-cell communication



An international team of researchers lays the foundation to examine how extracellular RNA and its carrier proteins found in bodily fluids function in a healthy as well as a diseased setting, potentially providing a means to accurately implement early detection and monitor disease processes.
Published Synthetic biology meets fashion in engineered silk



Engineers developed a method to create synthetic spider silk at high yields while retaining strength and toughness using mussel foot proteins.
Published Reinforcement learning: From board games to protein design



An AI strategy proven adept at board games like Chess and Go, reinforcement learning, has now been adapted for a powerful protein design program. The results show that reinforcement learning can do more than master board games. When trained to solve long-standing puzzles in protein science, the software excelled at creating useful molecules. In one experiment, proteins made with the new approach were found to be more effective at generating useful antibodies in mice than were previous methods. If this method is applied to the right research problems, it likely could accelerate progress in a variety of scientific fields.
Published AI system can generate novel proteins that meet structural design targets



A new machine-learning system can generate protein designs with certain structural features, and which do not exist in nature. These proteins could be utilized to make materials that have similar mechanical properties to existing materials, like polymers, but which would have a much smaller carbon footprint.
Published Engineering the next generation of cell and gene therapies



Investigators are developing a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using engineered stem cells that may eventually lead to personalized treatments.
Published Simple addition to corn bran could boost grain's nutritional value 15-35%



What if, by adding a couple of cell layers inside a corn kernel, the grain could become significantly richer in essential nutrients like iron, zinc, and protein? Such an improvement could benefit people who rely on corn for a large portion of their diet, as in many parts of the global south.