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Categories: Archaeology: General, Biology: Molecular

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Certain stem cells have a unique ability to move between growth compartments in hair follicles, but get stuck as people age and so lose their ability to mature and maintain hair color, a new study shows.

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Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei. DNA tension plays a surprising role in this. Nanoscientists now publish how they have visualized this.

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A hitherto unknown mechanism for DNA folding is described in a new study. The findings provide new insights into chromosomal processes that are vital to both normal development and to prevent disease.

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Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases. This has led to a growing demand for selective, efficient, and safe ways of delivering siRNA in cells. Now, in a cooperation between the Universities of Amsterdam and Leiden, researchers have developed dedicated molecular nanocages for siRNA delivery. In a paper just out in the Journal Chem they present nanocages that are easy to prepare and display tuneable siRNA delivery characteristics.

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Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail. This technology has potential uses in tissue engineering, regenerative medicine, and understanding how the body works. The scientists applied their new method to control the glow of a green fluorescent protein derived from Japanese eel muscle.

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Researchers have discovered how long ago the Australian Nullarbor plain dried out, with a new approach shedding light on how ancient climate change altered some of the driest regions of our planet.

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A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study now shows how two molecular mechanisms can work together make the bacterium extra resistant.

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Research has traced the evolutionary adaptations of octopus and squid sensing capabilities. The researchers describe for the first time the structure of an octopus chemotactile receptor, which octopus arms use for taste-by-touch exploration of the seafloor.

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The Xiongnu, contemporaries of Rome and Egypt, built their nomadic empire on the Mongolian steppe 2,000 years ago, emerging as Imperial China's greatest rival and even inspiring the construction of China's Great Wall. In a new study, researchers find that the Xiongnu were a multiethnic empire, with high genetic diversity found across the empire and even within individual extended elite families. At the fringes of the empire, women held the highest positions of power, and the highest genetic diversity was found among low-status male servants, giving clues to the process of empire building that gave rise to Asia's first nomadic imperial power.

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Researchers describe how the Epstein-Barr virus exploits genomic weaknesses to cause cancer while reducing the body's ability to suppress it.

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Origin-of-life chemists propose that glyoxylate could have been the original source of sugars on the 'prebiotic' Earth

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A research team has recently made a significant discovery about the evolutionary age of different type of cells in a small animal called Caenorhabditis elegans (C. elegans). By using single-cell transcriptomic data and refined phylostratigraphy, the team determines the transcriptomic age of individual cells, which means they are able to estimate the evolutionary origin of different cells based on the age of the genes expressed in the cells.

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The question of how prehistoric populations obtained sustainable food in the barren heights of the Tibetan Plateau has long attracted academic and popular interest. A new study highlights the critical role of dairy pastoralism in opening the plateau up to widespread, long-term human habitation.

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In a series of experiments, a team of researchers have compared de novo proteins with random-sequence proteins, looking at their stability and solubility. The results are set to advance basic research in this new field.

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Acylceramides and protein-bound ceramides are vital for the formation of the oral barrier in mice, similar to their role in skin, protecting from infection.

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Scientists have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers. With dietary restrictions, these processes could be reversed.

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Material left on the seafloor by bronze-age underwater volcanic eruptions is helping researchers better understand the size, hazards and climate impact of their parent eruptions, according to new research.

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Researchers discovered that males of the yellow crazy ant have maternal and paternal genomes in different cells of their body and are thus chimeras.

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Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

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New research investigates how cells divide, particularly in the fibrous environment of living tissue. Cells are typically studied in a flat environment, and the difference between flat and fibrous landscapes opens new windows into the behavior of cells and the diseases that impact them.