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Categories: Biology: Molecular, Paleontology: Early Mammals and Birds
Published Fungus-fighting protein could help overcome severe autoimmune disease and cancer
(via sciencedaily.com) Original source A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, eczema and other chronic disorders, new research has found. The discovery could pave the way for new and more effective drugs, without the nasty side effects of existing treatments. In addition to helping to manage severe autoimmune conditions, the breakthrough could also help treat all types of cancer.
Published Influx of water and salts propel immune cells through the body
(via sciencedaily.com) Original source Researchers have shown that an influx of water and ions into immune cells allows them to migrate to where they're needed in the body.
Published From infamy to ingenuity: Bacterial hijack mechanisms as advanced genetic tools
(via sciencedaily.com) Original source Researchers have uncovered the intricate molecular mechanism used by parasitic phytoplasma bacteria, known for inducing 'zombie-like' effects in plants.
Published 'Shocking' discovery: Electricity from electric eels may transfer genetic material to nearby animals
(via sciencedaily.com) Original source Researchers have discovered that electric eels can alter the genes of tiny fish larvae with their electric shock. Their findings help to better understand electroporation, a method by which genes can be transported using electricity.
Published Sugar permeation discovered in plant aquaporins
(via sciencedaily.com) Original source Aquaporins, which move water through membranes of plant cells, were not thought to be able to permeate sugar molecules, but researchers have observed sucrose transport in plant aquaporins for the first time, challenging this theory.
Published Macrophages 'eat' insulin-producing cells to regulate insulin after mice have given birth
(via sciencedaily.com) Original source Pregnancy brings a rise in pancreatic beta cells -- the cells that produce insulin. Shortly after birth, these cells return to their normal levels. The mechanisms behind this process had remained a mystery. But now a research group has revealed that white blood cells called macrophages 'eat' these cells.
Published Researchers have cracked the cellular code on protein folding, offering hope for new therapeutic avenues for many diseases
(via sciencedaily.com) Original source While we often think of diseases as caused by foreign bodies -- bacteria or viruses -- there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team of researchers recently leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy.
Published New technique efficiently offers insight into gene regulation
(via sciencedaily.com) Original source Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.
Published Unlocking the secret strength of marine mussels
(via sciencedaily.com) Original source How do you create strong, yet quick-release connections between living and non-living tissues? This is a question that continues to puzzle bioengineers who aim to create materials that bond together for advanced biomedical applications. Looking to nature for inspiration, this research zeroed in on the marine mussel byssus, a fibrous holdfast, which these bivalve mollusks use to anchor themselves in seashore habitats.
Published Shedding light on the synthesis of sugars before the origin of life
(via sciencedaily.com) Original source Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical pathway compatible with early Earth conditions, by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding life's origin.
Published Unknown animals were leaving bird-like footprints in Late Triassic Southern Africa
(via sciencedaily.com) Original source Ancient animals were walking around on bird-like feet over 210 million years ago, according to a new study.
Published Clever dosage control mechanism of biallelic genes
(via sciencedaily.com) Original source Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.
Published Key protein in blood vessel's growth identified
(via sciencedaily.com) Original source New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these family of proteins may lead to vascular malformations and the precise understanding of the whole process is instrumental in opening the door to new therapeutic approaches in the future.
Published Releasing brakes on biocatalysis
(via sciencedaily.com) Original source Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.
Published Scientists harness flower 'super power' to pave the way for new drug treatments
(via sciencedaily.com) Original source Researchers have developed a way of joining up the head and tail of a protein, making it more stable and easier to get into cells.
Published Scientist discovers potential brain link between stress, emotional eating
(via sciencedaily.com) Original source Scientists describe how they identified a molecule that may trigger over-consumption of comfort foods after a threatening event.
Published New clues into the head-scratching mystery of itch
(via sciencedaily.com) Original source Scientists show for the first time that bacteria can cause itch by activating nerve cells in the skin. The findings can inform new therapies to treat itch that occurs in inflammatory skin conditions like eczema and dermatitis.
Published Earliest known European common hippopotamus fossil reveals their Middle Pleistocene dispersal
(via sciencedaily.com) Original source Modern hippos first dispersed in Europe during the Middle Pleistocene, according to a new study.
Published Nutrient found in beef and dairy improves immune response to cancer
(via sciencedaily.com) Original source Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study.
Published Team discovers rules for breaking into Pseudomonas
(via sciencedaily.com) Original source Researchers report that they have found a way to get antibacterial drugs through the nearly impenetrable outer membrane of Pseudomonas aeruginosa, a bacterium that -- once it infects a person -- is notoriously difficult to treat.