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Categories: Biology: Molecular, Paleontology: Early Mammals and Birds

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Researchers used computational modeling to reveal finer details surrounding the outer shell of the COVID-19 virus. The work expands the scientific community's understanding of SARS-COV-2, and could lead to more refined antiviral therapies and better vaccines.

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The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.

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A group of researchers discovered that the rhodopsin -- a protein in the eye that detects light -- of whale sharks has changed to efficiently detect blue light, which penetrates deep-sea water easily. The amino acid substitutions -- one of which is counterintuitively associated with congenital stationary night blindness in humans -- aid in detecting the low levels of light in the deep-sea. Although these changes make the whale shark rhodopsin less thermally stable the deep-sea temperature, allows their rhodopsin to keep working. This suggests that the unique adaptation evolved to function in the low-light low-temperature environment where whale sharks live.

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Researchers discover that actin acts in the cell nucleus and is partly responsible for the expression of male sexual characteristics.

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Researchers identify the most promising advancements and greatest challenges of artificial mitochondria and chloroplasts. The team describes the components required to construct synthetic mitochondria and chloroplasts and identifies proteins as the most important aspects for molecular rotary machinery, proton transport, and ATP production. The authors believe it is important to create artificial cells with biologically realistic energy-generation methods that mimic natural processes; replicating the entire cell could lead to future biomaterials.

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A team of scientists designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

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To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team of scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.

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Squids and octopuses are masters of camouflage. But some aspects of how they become reversibly transparent are still 'unclear,' because researchers can't culture cephalopod skin cells in the lab. Now, researchers have replicated the tunable transparency of squid skin in mammalian cells, which are more easily cultured.

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Researchers have developed a hybrid micro-robot, the size of a single biological cell (about 10 microns across), that can be controlled and navigated using two different mechanisms -- electric and magnetic. The micro-robot is able to navigate between different cells in a biological sample, distinguish between different types of cells, identify whether they are healthy or dying, and then transport the desired cell for further study, such as genetic analysis.

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A parasite which has devastating impacts on agriculture and human health is the first pathogen to have its proteins located and mapped within its cells -- providing clues to their function and helping to identify potential drug targets.

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MitoQ, a mitochondrial antioxidant that is available to the public as a diet supplement, was found in a mouse study to reverse the detrimental effects that HIV and antiretroviral therapy (ART) have on mitochondria in the brain, heart, aorta, lungs, kidney and liver.

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Researchers have found that the body's process of removing old and damaged cell parts, is also an essential part of tackling infections that take hold within our cells, like TB. If this natural process can be harnessed with new treatments, it could present an alternative to, or improve use of antibiotics, especially where bacteria have become resistant to existing drugs.

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Researchers have uncovered a key role for a new type of cell in touch detection in the skin of the fruit fly.

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Damage in the human genome can be repaired. But this works better in germ cells, sperm and eggs, than in normal body cells. Responsible for this is the DREAM protein complex, which prevents the activation of all available repair mechanisms. A research team has now shown that normal body cells can also be repaired better once this complex has been deactivated. In the long run, the scientists hope to develop better therapies to prevent cancer and aging-associated diseases.

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Scientists have significantly advanced the race to control plant responses to temperature on a rapidly warming planet. Key to this breakthrough is miRNA, a molecule nearly 200,000 times smaller than the width of a human hair.

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Some plants can survive months without water, only to turn green again after a brief downpour. A recent study shows that this is not due to a 'miracle gene.' Rather, this ability is a consequence of a whole network of genes, almost all of which are also present in more vulnerable varieties.

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Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. Researchers have now described a distinct and novel subset of memory B cells that predict long-lived antibody responses to influenza vaccination in humans. These effector memory B cells appear to be poised for a rapid serum antibody response upon secondary challenge one year later.

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Researchers have developed a handheld sensor that tests perspiration for cortisol and provides results in eight minutes, a key advance in monitoring a hormone whose levels are a marker for many illnesses including various cancers.

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Researchers have 'hacked' the earliest stages of photosynthesis, the natural machine that powers the vast majority of life on Earth, and discovered new ways to extract energy from the process, a finding that could lead to new ways of generating clean fuel and renewable energy.

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Deleting a gene that promotes magnesium transport into mitochondria (which are cells' power plants) resulted in more efficient metabolism of sugar and fat in the energy centers. The result: skinny, healthy mice. Now the research team, has developed a small-molecule drug that accomplishes the same effect in mice.