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Categories: Biology: Molecular, Paleontology: Fossils

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Established treatments for cancer and other diseases often focus on inhibiting harmful enzymes to mitigate their effects. However, a more innovative approach has emerged: harnessing the cell's natural waste disposal system not just to deactivate but to entirely eradicate these proteins. Researchers have previously demonstrated the efficacy of this approach through two distinct methods. Now they unveil a third system capable of targeting and disposing of previously inaccessible proteins.

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Mounting evidence suggests that the secret to understanding human health and combating metabolic diseases lies hidden within the microscopic world of our gut bacteria. Recent research reveals that a specific fatty acid produced by gut bacteria directly influences fat metabolism in animals. This research is pivotal as it sheds light on the complex interplay between the diet, gut microbiota, and host metabolic health, offering insights that could open new avenues in our approach to managing metabolic disorders.

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Purple sulfur bacteria (PSB) convert light energy into chemical energy through photosynthesis. Interestingly, certain species can photosynthesize even in environments with low-calcium levels. Using cryo-electron microscopy, researchers unveiled the structure of light-harvesting complexes and elucidated the mechanism that facilitates photosynthesis under low-calcium conditions.

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A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.

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In a new study, paleontologists describe the oldest-known leaf-nosed bat fossils, which were found along the banks of the Panama Canal. They're also the oldest bat fossils from Central America, preserved 20-million years ago when Panama and the rest of North America were separated from southern landmass by a seaway at least 120 miles wide.

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By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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Consuming over 22% of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation and drive the disease risk, new study showed.

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Until recently, Orthacanthus gracilis could have been considered the 'John Smith' of prehistoric shark names, given how common it was. Three different species of sharks from the late Paleozoic Era -- about 310 million years ago -- were mistakenly given that same name, causing lots of grief to paleontologists who studied and wrote about the sharks through the years and had trouble keeping them apart. But now a professor has finished the arduous task of renaming two of the three sharks -- and in the process rediscovered a wealth of fossil fishes that had been stored at a museum for years but had been largely forgotten.

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Palaeontological analysis shows that a renowned fossil thought to show soft tissue preservation is in fact just paint. The fossil discovered in 1931 was thought to be an important specimen for understanding early reptile evolution. While not all of the celebrated fossil is a forgery, scientists urge caution in how the fossil is utilized in future.

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Researchers have identified a protein that evolved concurrently with the emergence of cellular compartments crucial for the multiplication of the toxoplasmosis pathogen.

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New research has shown that the tropical subsurface ocean gained oxygen during the Paleocene-Eocene Thermal Maximum (commonly referred to as PETM). During this short-lived interval of time in Earth s history that occurred 56 million years ago the average temperatures rose by up to six degrees within a few thousand years.

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When the female gametes in plants become fertilized, a signal from the sperm activates cell division, leading to the formation of new plant seeds. This activation can also be deliberately triggered without fertilization, as researchers have shown. Their findings open up new avenues for the asexual propagation of crop plants.

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Researchers report that ancient viruses may be to thank for myelin -- and, by extension, our large, complex brains. The team found that a retrovirus-derived genetic element or 'retrotransposon' is essential for myelin production in mammals, amphibians, and fish. The gene sequence, which they dubbed 'RetroMyelin,' is likely a result of ancient viral infection, and comparisons of RetroMyelin in mammals, amphibians, and fish suggest that retroviral infection and genome-invasion events occurred separately in each of these groups.

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A new study explores the weight great fossil sites have on our understanding of evolutionary relationships between fossil groups and quantified the power these sites have on our understanding of evolutionary history. Surprisingly, the authors discovered that the wind-swept sand deposits of the Late Cretaceous Gobi Desert's extraordinarily diverse and well-preserved fossil lizard record shapes our understanding of their evolutionary history more than any other site on the planet.

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A research team has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer's disease brain neurons.

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Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.

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White blood cells known as neutrophils feature a nucleus that is structured strikingly different than most nuclei. These unique shapes permit neutrophils to travel all over the body to combat invading pathogens. Scientists have now deciphered the shapeshifting puzzle of the neutrophil nucleus.

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From lab-grown chicken to cricket-derived protein, these innovative alternatives offer hope for a planet struggling with the environmental and ethical impacts of industrial agriculture. Now, scientists add a new recipe to the list -- cultured beef rice -- by growing animal muscle and fat cells inside rice grains. The method results in a nutritious and flavorful hybrid food that, once commercialized, could offer a more affordable protein alternative with a smaller carbon footprint.

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Scientists have determined how the well-known plant hormone ethylene is crucial in controlling the angle at which roots grow. The findings can be used to engineer plants and crops that withstand the environmental stresses of climate change and drought, and perhaps to create plants that remove carbon dioxide from the atmosphere and store it deep underground to help mitigate climate change.

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Scientists develop novel underwater bio-adhesive patches with mussel adhesive protein.