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Categories: Biology: Molecular, Paleontology: Fossils

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Researchers have created a new version of a microbe to compete economically with E. coli -- a bacteria commonly used as a research tool due to its ability to synthesize proteins -- to conduct low-cost and scalable synthetic biological experiments.

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A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them. The findings highlight how close -- yet still far -- researchers have come to developing a cure for HIV-1.

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Researchers have pinpointed the group of neurons in the nerve cord -- a structure analogous to our spinal cord -- that produce and pattern the fly's two major courtship songs. They've also measured neuronal activity in these cells while flies were singing to understand how these neurons control each type of song.

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The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.

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Scientists examined hundreds of birds in museum collections and discovered a suite of feather characteristics that all flying birds have in common. These 'rules' provide clues as to how the dinosaur ancestors of modern birds first evolved the ability to fly, and which dinosaurs were capable of flight.

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Snail shells are often colorful and strikingly patterned. This is due to pigments that are produced in special cells of the snail and stored in the shell in varying concentrations. Fossil shells, on the other hand, are usually pale and inconspicuous because the pigments are very sensitive and have already decomposed. Residues of ancient color patterns are therefore very rare. This makes a new discovery all the more astonishing: researchers found pigments in twelve-million-year-old fossilized snail shells.

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Nearly 400 exceptionally well-preserved fossils dating back 470 million years have been discovered in the south of France by two amateur paleontologists. The discovery provides unprecedented information on the polar ecosystems of the Ordovician period.

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Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.

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A new study identifies numerous pathways by which the gut microbiome may change the immune system.

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Researchers have identified a new approach to controlling bacterial infections. The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system (CBASS), is a natural mechanism used by certain bacteria to protect themselves from viral attacks. Bacteria self-destruct as a means to prevent the spread of virus to other bacterial cells in the population.

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A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.

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The rivers of Australia, which once flowed across its now dry interior, used to host a range of bizarre animals -- including a sleek predatory lobe-finned fish with large fangs and bony scales. The newly described fossil fish discovered in remote fossil fields west of Alice Springs has been named Harajicadectes zhumini by palaeontologists.

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Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.

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Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.

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A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.

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The algae P. antarctica has two forms of the enzyme that makes the amino acid methionine, one needing B12, and one that is slower, but doesn't need it. This means it has the ability to adapt and survive with low B12 availability. The presence of the MetE gene in P. antarctica gives the algae the ability to adapt to lower vitamin B12 availability, giving it a potential advantage to bloom in the early austral spring when bacterial production is low. P. antarctica takes in the CO2 and releases oxygen through photosynthesis. Understanding its ability to grow in environments with low vitamin B12 availability can help climate modelers make more accurate predictions.

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Seeing a glycoprotein on the envelope of the HIV virus snap open and shut in mere millionths of a second is giving investigators a new handle on the surface of the virus that could lead to broadly neutralizing antibodies for an AIDS vaccine. Being able to attach an antibody specifically to this little structure that would prevent it from popping open would be key.

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A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.

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In the fossil record, trees typically are preserved with only their trunks. They don't usually include any leaves to show what their canopies and overall forms may have looked like. In a new study, researchers describe fossilized trees from New Brunswick, Canada with a surprising and unique three-dimensional crown shape.

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Disrupted function of 'cleaning cells' in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not. A study describes this newly discovered mechanism.