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Categories: Biology: Molecular, Offbeat: Plants and Animals
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published Australian study proves 'humans are planet's most frightening predator'
(via sciencedaily.com) Original source A new study demonstrates that kangaroos, wallabies and other Australian marsupials fear humans far more than any other predator.
Published New AI accurately predicts fly behavior
(via sciencedaily.com) Original source Researchers trained an AI model to accurately predict male fruit flies' courtship behavior in response to any sight of a female. This breakthrough offers new insight into how the brain processes visual data and may someday pave the way for artificial vision technology.
Published Cuddled cows who work as therapy animals showed a strong preference for women compared to men, study finds
(via sciencedaily.com) Original source A new study reveals that cows who are cuddled as therapy animals showed a strong preference for interactions with women when compared to men. In turn, the research, which opens a new era on whether some therapies may be initially stronger based upon gender and not procedure, highlighted that the women also reported greater attachment behaviors towards the steers.
Published Study finds widespread 'cell cannibalism,' related phenomena across tree of life
(via sciencedaily.com) Original source Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.
Published Detecting odors on the edge: Researchers decipher how insects smell more with less
(via sciencedaily.com) Original source While humans feature a sophisticated sense of smell, insects have a much more basic olfactory system. Yet they depend upon smell to survive. Scientists have figured out how fruit flies use a simple but efficient system to recognize odors, and the answer lies at the edges of their antennae.
Published Researchers discover hidden step in dinosaur feather evolution
(via sciencedaily.com) Original source Scientists discover 'zoned development' in dinosaur skin, with zones of reptile-style scales and zones of bird-like skin with feathers. A new dinosaur skin fossil has been found to be composed of silica -- the same as glass.
Published Studies reveal cell-by-cell changes caused when pig hearts and kidneys are transplanted into humans
(via sciencedaily.com) Original source Two new studies detail the changes seen at the single-cell level in pig organs and recipient human bodies before, during, and just after the xenotransplantation surgeries in the decedents.
Published Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
(via sciencedaily.com) Original source Although periodontitis is an extremely prevalent disorder, it is challenging to conduct detailed and comprehensive analyses of its progression at the cellular level. Recently, researchers developed an improved periodontitis mouse model that simplifies the collection and analysis of multiple periodontal tissue types. Using this model, they clarified the role of an important signaling pathway in the inflammatory response of periodontal tissue, paving the way for better diagnostic and therapeutic strategies for periodontitis.
Published Modern plant enzyme partners with surprisingly ancient protein
(via sciencedaily.com) Original source Scientists have discovered that a protein responsible for the synthesis of a key plant material evolved much earlier than suspected. This new research explored the origin and evolution of the biochemical machinery that builds lignin, a structural component of plant cell walls with significant impacts on the clean energy industry.
Published Sweet taste receptor affects how glucose is handled metabolically by humans
(via sciencedaily.com) Original source The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption and assimilation, as part of this system. A team found that stimulation and inhibition of the sweet receptor helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes.
Published Scientists discover mechanism of sugar signaling in plants
(via sciencedaily.com) Original source A paper describes how the moving parts of a particular plant protein control whether plants can grow and make energy-intensive products such as oil -- or instead put in place a series of steps to conserve precious resources. The study focuses specifically on how the molecular machinery is regulated by a molecule that rises and falls with the level of sugar -- plants' main energy source.
Published Plants restrict use of 'Tipp-Ex proteins'
(via sciencedaily.com) Original source Plants have special corrective molecules at their disposal that can make retrospective modifications to copies of genes. However, it would appear that these 'Tipp-Ex proteins' do not have permission to work in all areas of the cell, only being used in chloroplasts and mitochondria. A study has now explained why this is the case. It suggests that the correction mechanism would otherwise modify copies that have nothing wrong with them, with fatal consequences for the cell.
Published Fruit fly wing research offers window into birth defects
(via sciencedaily.com) Original source If fruit fly wings do not develop into the right shape, the flies will die. Researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.
Published Ancient arachnid from coal forests of America stands out for its spiny legs
(via sciencedaily.com) Original source The spiny legged 308-million-year-old arachnid Douglassarachne acanthopoda was discovered the famous Mazon Creek locality.
Published A new 'rule of biology' may have come to light, expanding insight into evolution and aging
(via sciencedaily.com) Original source A molecular biologist may have found a new 'rule of biology.' The rule challenges long-held notions that most living organisms prefer stability over instability because stability requires less energy and fewer resources.
Published New sensor gives unprecedented look at changes in cell's energy 'currency'
(via sciencedaily.com) Original source A new sensor is giving researchers the best look yet at ATP levels inside living cells, enabling scientists to study in greater detail than ever before how fluctuations in this cellular currency affect the cell and contribute to disease.
Published Otters, especially females, use tools to survive a changing world
(via sciencedaily.com) Original source Sea otters are one of the few animals that use tools to access their food, and a new study has found that individual sea otters that use tools -- most of whom are female -- are able to eat larger prey and reduce tooth damage when their preferred prey becomes depleted.
Published How neighboring whale families learn each other's vocal style
(via sciencedaily.com) Original source Researchers have developed a method to investigate sperm whale communication by determining their vocal style, finding that groups living in close proximity can develop similar styles to each other.
Published How did sabre-toothed tigers acquire their long upper canine teeth?
(via sciencedaily.com) Original source In a groundbreaking study an international team of scientists has investigated the evolutionary patterns behind the development of sabre teeth, with some unexpected results along the way.