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Categories: Biology: Molecular, Offbeat: Earth and Climate

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Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.

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Researchers have discovered that a worm commonly used in the study of biology uses a set of proteins unlike those seen in other studied organisms to protect the ends of its DNA.

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Multidrug-resistant bacterial infections that cannot be treated by any known antibiotics pose a serious global threat. A research team has now introduced a method for the development of novel antibiotics to fight resistant pathogens. The drugs are based on protein building blocks with fluorous lipid chains.

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Scientists are amazed at the discovery of a bristle worm with such sharp-seeing eyes that they can measure up to those of mammals and octopuses. The researchers suspect that these marine worms may have a secretive language, which uses UV light only seen by their own species. The advanced vision of such a primitive creature helps to finally settle an epic debate about the evolution of eyes.

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Researchers developed a foundational language model to decode mRNA sequences and optimize those sequences for vaccine development. The tool shows broader promise as a means for studying molecular biology.

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During archaeological excavations in the Schoningen open-cast coal mine in 1994, the discovery of the oldest, remarkably well-preserved hunting weapons known to humanity caused an international sensation. Spears and a double-pointed throwing stick were found lying between animal bones about ten meters below the surface in deposits at a former lakeshore. In the years that followed, extensive excavations have gradually yielded numerous wooden objects from a layer dating from the end of a warm interglacial period 300,000 years ago. The findings suggested a hunting ground on the lakeshore.

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Human activity is changing the way water flows between the Earth and atmosphere in complex ways and with likely long-lasting consequences that are hard to picture. Researchers enlisted water scientists from around the globe to write story-based scenarios about the possible futures humanity is facing but perhaps can't quite comprehend yet. The results are part of a creative pathway to understand atmospheric water research with an eye towards the potential economic and policy issues that may be just beyond the horizon.

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Biophysicists have demonstrated how heat flows through rock fissures could have created the conditions for the emergence of life.

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Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.

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A new study finds that UCYN-A, a species of nitrogen-fixing cyanobacteria, may be evolving organelle-like characteristics.

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Researchers have discovered a new bacterial killer that can target common lung infection caused by Burkholderia bacteria that has exciting potential for biotechnological applications.

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A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study reveals the role of a sugar called sialic acid in this invasion process. The findings have major implications for malaria vaccine and drug development.

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A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication by assuring faithful transmision of genetic materials when cells divide, the complexity of their genomic organization had been almost impossible to study. The lack of centromere sequences hindered exploration of how these regions help maintain genetic integrity. Now, advanced technologies have shown scientists how greatly centromeres differ in size and structure.

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There is room for just one small bottle in the world's first refrigerator that is cooled with artificial muscles made of nitinol, a nickel-titanium alloy. But the mini-prototype is groundbreaking: it shows that elastocalorics is becoming a viable solution for practical applications. This climate-friendly cooling and heating technology is far more energy-efficient and sustainable than current methods.

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A group of scholars calculated the amount of energy used by AI tools for the tasks of writing and illustrating and compared it to the average amount of energy humans use for the same processes. Their results showed artificial intelligence results in hundreds of times less carbon emissions than humans. This does not mean, however, that AI can or should replace humans in those tasks, simply that its energy usage is less. The better approach is a partnership between humans and AI, the authors write.

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Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.

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Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.

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Biologists have uncovered a quality control timing mechanism tied to cell division. The 'stopwatch' function keeps track of mitosis and acts as a protective measure when the process takes too long, preventing the formation of cancerous cells.

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Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.

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Researchers have developed an organic photovoltaic film that is both waterproof and flexible, allowing a solar cell to be put onto clothes and still function correctly after being rained on or even washed.