Showing 20 articles starting at article 1
Categories: Biology: Molecular
Published Strength training activates cellular waste disposal
(via sciencedaily.com) Original source The elimination of damaged cell components is essential for the maintenance of the body's tissues and organs. An international research team has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such mechanisms. The findings could form the basis for new therapies for heart failure and nerve diseases, and even afford benefits for manned space missions.
Published Revealing DNA behavior in record time
(via sciencedaily.com) Original source Studying how single DNA molecules behave helps us to better understand genetic disorders and design better drugs. Until now however, examining DNA molecules one-by-one was a slow process. Biophysicists have developed a technique that speeds up screening of individual DNA molecules at least a thousand times. With this technology, they can measure millions of DNA molecules within a week instead of years to decades.
Published Engineers design lookalike drug carrier to evade lung's lines of defense
(via sciencedaily.com) Original source Managing hard-to-treat respiratory illnesses like asthma and pulmonary fibrosis just got easier if a new drug-carrying molecule is as sneaky as its inventors think.
Published Gut molecule slows fat burning during fasting
(via sciencedaily.com) Original source In a struggle that probably sounds familiar to dieters everywhere, the less a Caenorhabditis elegans (C. elegans) worm eats, the more slowly it loses fat. Now, scientists have discovered why: a small molecule produced by the worms' intestines during fasting travels to the brain to block a fat-burning signal during this time.
Published Next time you beat a virus, thank your microbial ancestors
(via sciencedaily.com) Original source When you get infected with a virus, some of the first weapons your body deploys to fight it were passed down to us from our microbial ancestors billions of years ago. According to new research, two key elements of our innate immune system came from a group of microbes called Asgard archaea.
Published Life from a drop of rain: New research suggests rainwater helped form the first protocell walls
(via sciencedaily.com) Original source New research shows that rainwater could have helped create a meshy wall around protocells 3.8 billion years ago, a critical step in the transition from tiny beads of RNA to every bacterium, plant, animal, and human that ever lived.
Published Engineered Bacteria make thermally stable plastics similar to polystyrene and PET
(via sciencedaily.com) Original source Bioengineers around the world have been working to create plastic-producing microbes that could replace the petroleum-based plastics industry. Now, researchers have overcome a major hurdle: getting bacteria to produce polymers that contain ring-like structures, which make the plastics more rigid and thermally stable. Because these molecules are usually toxic to microorganisms, the researchers had to construct a novel metabolic pathway that would enable the E. coli bacteria to both produce and tolerate the accumulation of the polymer and the building blocks it is composed of. The resulting polymer is biodegradable and has physical properties that could lend it to biomedical applications such as drug delivery, though more research is needed.
Published Benefits and downside of fasting
(via sciencedaily.com) Original source Researchers identified a signaling pathway in mice that boosts intestinal stem cells' regeneration abilities after fasting. When cancerous mutations occurred during this regenerative period, mice were more likely to develop early-stage intestinal tumors.
Published Self-repairing mitochondria use novel recycling system
(via sciencedaily.com) Original source A newly identified identified cellular mechanism allows mitochondria to recycle localized damage and maintain healthy function.
Published Surprising mechanism for removing dead cells identified
(via sciencedaily.com) Original source A tandem signaling process turns ordinary cells into an efficient cleanup crew.
Published Compound in rosemary extract can reduce cocaine sensitivity
(via sciencedaily.com) Original source A team of researchers has discovered that an antioxidant found in rosemary extract can reduce volitional intakes of cocaine by moderating the brain's reward response, offering a new therapeutic target for treating addiction.
Published Researchers teaching artificial intelligence about frustration in protein folding
(via sciencedaily.com) Original source Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial intelligence (AI) technology has made it possible to predict what proteins look like in their resting state, figuring out how they move is still challenging because there is not enough direct data from experiments on protein motions to train the neural networks.
Published Deadly sea snail toxin could be key to making better medicines
(via sciencedaily.com) Original source Scientists are finding clues for how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.
Published Gut microbial pathway identified as target for improved heart disease treatment
(via sciencedaily.com) Original source Researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study found phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.
Published New insights on how bird flu crosses the species barrier
(via sciencedaily.com) Original source The avian influenza virus needs to mutate to cross the species barrier and to infect and replicate within mammalian cells. Scientists have now deciphered the structure of the avian influenza virus's polymerase when it interacts with a human protein essential for the virus to replicate within the cell. The structure of this replication complex provides important information about the mutations that avian influenza polymerase must undergo to adapt to mammals, including humans. These results can help scientists monitor the evolution and adaptability of bird flu strains, such as H5N1 or H7N9, towards infecting other species.
Published Searching old stem cells that stay young forever
(via sciencedaily.com) Original source The sea anemone Nematostella vectensis is potentially immortal. Using molecular genetic methods, developmental biologists have now identified possible candidates for multipotent stem cells in the sea anemone for the first time. These stem cells are regulated by evolutionary highly conserved genes.
Published Preliminary study shows potential of Manuka honey as a nutraceutical for breast cancer
(via sciencedaily.com) Original source A new study found that Manuka honey could potentially be an alternative, natural option for breast cancer prevention and treatment -- particularly for estrogen receptor (ER)-positive breast cancer, the most common subtype of breast cancer that accounts for about 70-80% of all breast cancer cases.
Published Probiotics during pregnancy shown to help moms and babies
(via sciencedaily.com) Original source Giving probiotics to pregnant mice can enhance both the immune system and behavior of the mothers and their offspring.
Published Zebrafish use surprising strategy to regrow spinal cord
(via sciencedaily.com) Original source A new study maps out a detailed atlas of all the cells involved in regenerating the zebrafish spinal cord. In an unexpected finding, the researchers showed that survival and adaptability of the severed neurons themselves is required for full spinal cord regeneration. Surprisingly, the study showed that stem cells capable of forming new neurons play a complementary role but don t lead the process.
Published Surprise finding in study of environmental bacteria could advance search for better antibiotics
(via sciencedaily.com) Original source Researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial cell's 'envelope' or enclosure is key to its survival, the finding could advance the search for new and better antibiotics.