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Categories: Biology: Marine, Biology: Molecular
Published Researchers apply quantum computing methods to protein structure prediction
(via sciencedaily.com) Original source Researchers recently published findings that could lay the groundwork for applying quantum computing methods to protein structure prediction.
Published hnRNPM, a guardian of the integrity of cellular protein production
(via sciencedaily.com) Original source Researchers have discovered that the protein hnRNPM prevents the cell from making mistakes while it is producing new proteins, which helps maintain the integrity of this vital process.
Published Editing without 'cutting': Molecular mechanisms of new gene-editing tool revealed
(via sciencedaily.com) Original source New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms contributes greatly to designing gene-editing tools accurate enough for gene therapy treatments.
Published Chicken feathers to deliver chemotherapy drugs and repair enzymes
(via sciencedaily.com) Original source A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
Published Researchers improve satellite surveillance of emperor penguins
(via sciencedaily.com) Original source New phenological and behavioral models will help scientists collect more accurate counts of emperor penguins. Emperor penguins are at the top of the food web. They are a reflection of how lower levels of the marine food web are being impacted by climate change. Systematic data collection on the biological component of ecosystems is still in its infancy, especially in harsh environments, in which consistent and repeatable research is particularly hard to achieve.
Published Some species may tolerate climate change better than expected
(via sciencedaily.com) Original source A new model reassesses the proportion of terrestrial and marine species threatened with extinction by climate change. While the forecasts of traditional models estimate that the diversity of terrestrial species in tropical areas could decrease by 54% between now and 2041-2060, this model is more moderate, predicting a decrease of 39%. Nevertheless, this proportion remains alarming and confirms the importance of taking urgent measures to mitigate climate change and its impact on biodiversity.
Published Marine Protected Areas don't line up with core habitats of rare migratory fish, finds new research
(via sciencedaily.com) Original source 62% of Marine Protected Areas (MPAs) designated to protect rare migratory fish species are outside of their core habitats, according to a new modeling study.
Published Intermittent fasting shows promise in improving gut health, weight management
(via sciencedaily.com) Original source Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction. The findings could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.
Published The secret sex life of coral revealed
(via sciencedaily.com) Original source Corals play an essential role in ocean ecosystems, and like many organisms, they are under threat from climate change and other human activities. To better protect coral, it's first necessary to understand them, in particular their reproductive life cycle, which only happens once a year. For the first time, researchers have produced a model for coral spawning, based on various environmental factors. They achieved this by tapping an often overlooked source of aquatic knowledge, an aquarium.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'Cloaked' proteins deliver cancer-killing therapeutics into cells
(via sciencedaily.com) Original source Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Global activity of seafloor biodiversity mapped
(via sciencedaily.com) Original source A team of scientists has used artificial intelligence (AI) to map the activities of seafloor invertebrate animals, such as worms, clams and shrimps, across all the oceans of the world.
Published Investigating the origin of circatidal rhythms in freshwater snails
(via sciencedaily.com) Original source While most organisms have biological clocks synchronized with the day-night cycle (circadian rhythms), marine animals in tidal areas have also developed circatidal rhythms to align with the tidal cycle. Comparing the activity and genetic expression of snails from tidal and non-tidal areas, researchers demonstrate that circatidal rhythms develop as snails adapt to tidal environments. These findings highlight the flexibility of biological clocks, enabling organisms to adjust their rhythms according to the environment.
Published Observing mammalian cells with superfast soft X-rays
(via sciencedaily.com) Original source Researchers have developed a new technique to view living mammalian cells. The team used a powerful laser, called a soft X-ray free electron laser, to emit ultrafast pulses of illumination at the speed of femtoseconds, or quadrillionths of a second. With this they could capture images of carbon-based structures in living cells for the first time, before the soft X-ray radiation damaged them.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development
(via sciencedaily.com) Original source Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Novel approach to interrogate tissue-specific protein-protein interactions
(via sciencedaily.com) Original source Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published Biodiversity in crabs: More than counting species
(via sciencedaily.com) Original source Researchers compare the shield shapes of crabs and find unexpected differentiation.
Published Constantly on the hunt for food: Harbor porpoises more vulnerable than previously thought
(via sciencedaily.com) Original source Constantly on the hunt for food: Harbor porpoises more vulnerable than previously thought to the disturbances from humans. The small whales spend more than 60 percent of their day hunting small fish to stay warm in the cold waters. New research shows that harbor porpoises spend little energy on this hunting strategy, but that it makes them vulnerable to human disturbance.
Published Tracking down the genetic causes of lupus to personalize treatment
(via sciencedaily.com) Original source Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.