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Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Bioinformatics: Researchers develop a new machine learning approach      (via sciencedaily.com)     Original source 

To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular
Published

A novel pathway regulating lipid biosynthesis by fatty acids      (via sciencedaily.com)     Original source 

Sterol regulatory element-binding proteins (SREBPs) play a crucial role in lipid biosynthesis. In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid biosynthesis. Moreover, the team unveiled, for the first time, that the biosynthesis process of fatty acid in the liver is activated by saturated fatty acids and inhibited by polyunsaturated fatty acids, providing new insights into the intricate workings of this cleavage system.

Biology: Cell Biology Biology: Genetics Biology: Microbiology Biology: Molecular
Published

New insights into what helps Salmonella cause infections      (via sciencedaily.com)     Original source 

In a new study, researchers have discovered how a system of proteins, called TamAB, helps Salmonella survive under the harsh conditions inside macrophages.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Molecular Chemistry: Biochemistry
Published

3D in vitro human atherosclerosis model for high-throughput drug screening      (via sciencedaily.com)     Original source 

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Offbeat: General Offbeat: Plants and Animals
Published

Researchers create light-powered yeast, providing insights into evolution, biofuels, cellular aging      (via sciencedaily.com)     Original source 

Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular Chemistry: Biochemistry Chemistry: General Chemistry: Organic Chemistry Chemistry: Thermodynamics
Published

Spying on a shape-shifting protein      (via sciencedaily.com)     Original source 

Researchers are using crystallography to gain a better understanding of how proteins shapeshift. The knowledge can provide valuable insight into stopping and treating diseases.

Biology: Biochemistry Biology: Cell Biology Biology: Genetics Biology: Molecular Environmental: General Environmental: Water Geoscience: Earth Science Geoscience: Geochemistry Geoscience: Geology
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Study uncovers potential origins of life in ancient hot springs      (via sciencedaily.com)     Original source 

A research team investigated how the emergence of the first living systems from inert geological materials happened on the Earth, more than 3.5 billion years ago. Scientists found that by mixing hydrogen, bicarbonate, and iron-rich magnetite under conditions mimicking relatively mild hydrothermal vent results in the formation of a spectrum of organic molecules, most notably including fatty acids stretching up to 18 carbon atoms in length.

Biology: Biochemistry Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Microbiology Biology: Molecular Paleontology: Fossils Paleontology: General
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Even the oldest eukaryote fossils show dazzling diversity and complexity      (via sciencedaily.com)     Original source 

The sun has just set on a quiet mudflat in Australia's Northern Territory; it'll set again in another 19 hours. A young moon looms large over the desolate landscape. No animals scurry in the waning light. No leaves rustle in the breeze. No lichens encrust the exposed rock. The only hint of life is some scum in a few puddles and ponds. And among it lives a diverse microbial community of our ancient ancestors.

Biology: Biochemistry Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Lab-grown retinas explain why people see colors dogs can't      (via sciencedaily.com)     Original source 

With human retinas grown in a petri dish, researchers discovered how an offshoot of vitamin A generates the specialized cells that enable people to see millions of colors, an ability that dogs, cats, and other mammals do not possess. The findings increase understanding of color blindness, age-related vision loss, and other diseases linked to photoreceptor cells. They also demonstrate how genes instruct the human retina to make specific color-sensing cells, a process scientists thought was controlled by thyroid hormones.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Protein complex discovered to control DNA repair      (via sciencedaily.com)     Original source 

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.

Biology: Biochemistry Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Marine Biology: Molecular Environmental: Water Geoscience: Geochemistry Geoscience: Geography
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Toxic algae blooms: Study assesses potential health hazards to humans      (via sciencedaily.com)     Original source 

Water samples from 20 sites were tested using a panel of immortalized human cell lines corresponding to the liver, kidney and brain to measure cytotoxicity. Results show that each control toxin induced a consistent pattern of cytotoxicity in the panel of human cell lines assayed. Known toxins were seen only during blooms. Because cell toxicity was seen in the absence of blooms, it suggests that there might be either emergent toxins or a combination of toxins present at those times. Findings suggest that other toxins with the potential to be harmful to human health may be present in the lagoon.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Genetics Biology: Microbiology Biology: Molecular
Published

A new type of plant metalloreductase maintains root growth under low phosphorus      (via sciencedaily.com)     Original source 

Phosphorus is essential for undisturbed plant growth and development. However, in many soils, phosphorus is only poorly available. One mechanism used by plants to increase phosphorus availability is the release of malate, an organic acid, which can form complexes with iron or aluminium in the soil, thereby liberating sorbed phosphate. However, this response can also result in iron overaccumulation, which can inhibit root growth.

Biology: Biochemistry Biology: General Biology: Marine Ecology: Nature Ecology: Sea Life Geoscience: Environmental Issues Geoscience: Geochemistry Geoscience: Geography Geoscience: Oceanography
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Focus on biological processes does not capture the whole picture      (via sciencedaily.com)     Original source 

The ocean plays a crucial role in the storage of carbon dioxide (CO2). The so-called marine biological carbon pump is an important research topic in this context. However a key component is often overlooked. Colleagues outline why it is insufficient to focus solely on biological processes when investigating the accumulation of CO2 in the ocean by the biological carbon pump.

Biology: Marine Biology: Zoology Environmental: Ecosystems
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A red knot's character is formed in first year of life      (via sciencedaily.com)     Original source 

In any group of red knots, respective individuals exhibit a remarkable array of distinct character types. Birds with an exploratory character are motivated to investigate their environment and readily explore unfamiliar areas. Meanwhile, birds with inactive character types are content to remain in familiar territory. Interestingly, the birds do not appear to hatch with predetermined character types. Their characters are formed later, in the first year of life, as a result of their experiences in the Wadden Sea.

Biology: Marine Ecology: Extinction Ecology: General Ecology: Research Ecology: Sea Life Environmental: Ecosystems
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In hot water: Coral resilience in the face of climate change      (via sciencedaily.com)     Original source 

Researchers have been studying the effects of climate change on coral reefs. Monitoring two coral species off the coast of Hawaii, one team found that local adaptations in response to near-severe heat stress allowed certain populations to endure such events.

Biology: Marine Biology: Zoology Ecology: Sea Life Environmental: Ecosystems Environmental: General Environmental: Water Geoscience: Earth Science Geoscience: Environmental Issues Geoscience: Geography Geoscience: Oceanography
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Acidity of Antarctic waters could double by century's end, threatening biodiversity      (via sciencedaily.com)     Original source 

Without drastically reducing global emissions, the Antarctic Ocean could become too acidic for hundreds of species living there, many already endangered by rising temperatures and sea ice loss.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
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Smart skin bacteria are able to secrete and produce molecules to treat acne      (via sciencedaily.com)     Original source 

An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.

Biology: Cell Biology Biology: Developmental Biology: General Biology: Marine Biology: Zoology Ecology: Sea Life Offbeat: General Offbeat: Plants and Animals
Published

Stranger than friction: A force initiating life      (via sciencedaily.com)     Original source 

As the potter works the spinning wheel, the friction between their hands and the soft clay helps them shape it into all kinds of forms and creations. In a fascinating parallel, sea squirt oocytes (immature egg cells) harness friction within various compartments in their interior to undergo developmental changes after conception.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Ecology: Animals
Published

Large-scale mapping of pig genes could pave the way for new human medicines      (via sciencedaily.com)     Original source 

Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities. This new knowledge can be used to ensure healthier pigs for farmers and can help the pharmaceutical industry breed better laboratory pigs for testing new medicines.