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Categories: Biology: Marine, Biology: Molecular
Published A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA
(via sciencedaily.com) Original source CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.
Published Unique characteristics of previously unexplored protein discovered
(via sciencedaily.com) Original source Research achieves scientific breakthrough in understanding cell division.
Published Immune system in the spotlight
(via sciencedaily.com) Original source Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system. For analysis of the necessary complex antigen processing and transport processes in real time, researchers have developed a 'cage' that is opened with light to release trapped antigens at a specific place and time.
Published Loss of oxygen in lakes and oceans a major threat to ecosystems, society, and planet
(via sciencedaily.com) Original source Oxygen is a fundamental requirement of life, and the loss of oxygen in water, referred to as aquatic deoxygenation, is a threat to life at all levels. In fact, researchers describe how ongoing deoxygenation presents a major threat to the stability of the planet as a whole.
Published New ways to study spinal cord malformations in embryos
(via sciencedaily.com) Original source Scientists have successfully created mechanical force sensors directly in the developing brains and spinal cords of chicken embryos, which they hope will improve understanding and prevention of birth malformations such as spina bifida.
Published A better way to make RNA drugs
(via sciencedaily.com) Original source RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste. Researchers report a new, enzyme-based RNA synthesis method that can produce strands of RNA with both natural and modified nucleotides without the environmental hazards.
Published Muscle machine: How water controls the speed of muscle contraction
(via sciencedaily.com) Original source The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study.
Published Hatcheries can boost wild salmon numbers but reduce diversity, studies find
(via sciencedaily.com) Original source The ability of salmon hatcheries to increase wild salmon abundance may come at the cost of reduced diversity among wild salmon, according to a new study.
Published Nanoplastics and 'forever chemicals' disrupt molecular structures, functionality
(via sciencedaily.com) Original source Researchers have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS) -- commonly known as forever chemicals -- disrupt biomolecular structure and function. The work shows that the compounds can alter proteins found in human breast milk and infant formulas -- potentially causing developmental issues downstream.
Published Opening the right doors: 'Jumping gene' control mechanisms revealed
(via sciencedaily.com) Original source International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of 'jumping genes.' DDM1 makes 'jumping genes' more accessible for transcription-suppressing chemical marks to be deposited. Because a variant of this protein exists in humans, the discovery provides insight into genetic conditions caused by such 'jumping gene' mutations.
Published Urban seagulls still prefer seafood
(via sciencedaily.com) Original source Seagull chicks raised on an 'urban' diet still prefer seafood.
Published First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin
(via sciencedaily.com) Original source An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted. This unprecedented level of structural detail was retained because the mammoth underwent freeze-drying shortly after it died, which meant that its DNA was preserved in a glass-like state.
Published A new species of extinct crocodile relative rewrites life on the Triassic coastline
(via sciencedaily.com) Original source The surprising discovery of a new species of extinct crocodile relative from the Triassic Favret Formation of Nevada, USA, rewrites the story of life along the coasts during the first act of the Age of Dinosaurs. The new species Benggwigwishingasuchus eremicarminis reveals that while giant ichthyosaurs ruled the oceans, the ancient crocodile kin known as pseudosuchian archosaurs ruled the shores across the Middle Triassic globe between 247.2 and 237 million years ago.
Published Atlas of proteins reveals inner workings of cells
(via sciencedaily.com) Original source Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.
Published The detection of a massive harmful algal bloom in the Arctic prompts real-time advisories to western Alaskan communities
(via sciencedaily.com) Original source A summer 2022 research cruise that detected a massive and highly toxic harmful algal bloom (HAB) in the Bering Strait has provided a dramatic example of science that utilized new technology to track a neurotoxic HAB and effectively communicate that information in real-time to protect remote communities in coastal Alaska.
Published Big gain in battle against harmful bacteria
(via sciencedaily.com) Original source An unexpected find has enabled important progress to be made in the battle against harmful bacteria.
Published New one-step method to make multiple edits to a cell's genome
(via sciencedaily.com) Original source A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.
Published Whale remains tracked to highlight sustainable disposal benefits
(via sciencedaily.com) Original source A new study highlights the sustainable, cultural and ecosystem benefits of offshore removal or decomposition of whale remains. The study tracked the remains of a humpback whale that was intercepted before washing up on the shoreline, then repositioned 30km offshore and fitted with a satellite tag that tracked its position as it drifted with the wind and currents for 6 days before falling to the seabed.
Published Groundbreaking study reveals oceanic seabirds chase tropical cyclones
(via sciencedaily.com) Original source A new study reveals that the rare Desertas Petrels (Pterodroma deserta), a wide-ranging seabird in the North Atlantic, exhibit unique foraging behaviors during hurricane season. Contrary to other pelagic seabirds, these petrels do not avoid intense tropical cyclones but instead exploit the dynamic conditions for their benefit, providing new insights into the impact of cyclones on open ocean marine life.
Published 'Sacrifice' of virus data clears the path to open a disease discovery pipeline
(via sciencedaily.com) Original source Tens of millions of still-unknown or misunderstood viruses can cause diseases -- including new pandemics -- and affect the health of valuable terrestrial and marine environments. Now a new pipeline to investigate the 'virosphere,' or all the genomes of viruses and bacteriophages (viruses that attack bacteria) of the world, has been developed by an international collaboration.