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Categories: Biology: Biotechnology, Biology: Botany
Published A comprehensive derivative synthesis method for development of new antimicrobial drugs
(via sciencedaily.com) Original source A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.
Published Opening the right doors: 'Jumping gene' control mechanisms revealed
(via sciencedaily.com) Original source International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of 'jumping genes.' DDM1 makes 'jumping genes' more accessible for transcription-suppressing chemical marks to be deposited. Because a variant of this protein exists in humans, the discovery provides insight into genetic conditions caused by such 'jumping gene' mutations.
Published Wild plants and crops don't make great neighbors, research finds
(via sciencedaily.com) Original source Native plants and non-native crops do not fare well in proximity to one another, attracting pests that spread diseases in both directions, according to two new studies.
Published First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin
(via sciencedaily.com) Original source An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted. This unprecedented level of structural detail was retained because the mammoth underwent freeze-drying shortly after it died, which meant that its DNA was preserved in a glass-like state.
Published Novel genome editing approach restores hearing in adult preclinical models with genetic deafness
(via sciencedaily.com) Original source Researchers restored hearing in preclinical mouse models with a specific form of inherited deafness called DFNA50 caused by mutations in microRNA, by using a novel in vivo CRISPR genome editing approach. Since mouse and human microRNAs have identical sequences, the researchers hope this work can one day be translated into applications for humans.
Published Atlas of proteins reveals inner workings of cells
(via sciencedaily.com) Original source Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.
Published Not so simple: Mosses and ferns offer new hope for crop protection
(via sciencedaily.com) Original source Mosses, liverworts, ferns and algae may offer an exciting new research frontier in the global challenge of protecting crops from the threat of disease.
Published Phage-derived enzyme targets E. faecalis biofilms to mitigate acute graft-versus-host disease
(via sciencedaily.com) Original source Acute graft-versus-host disease occurs when donor immune cells attack the recipient's tissues after an allogeneic hematopoietic stem cell transplantation (allo-HCT). Researchers recently identified a bacteriophage-derived enzyme called endolysin capable of targeting biofilms formed by Enterococcus faecalis. Their findings offer hope for tailored interventions in allo-HCT.
Published Discovery could help reduce adverse side effects of popular next-generation obesity medications
(via sciencedaily.com) Original source By teasing apart the therapeutic benefits from the adverse effects of new generation obesity medications, researchers found a population of neurons in the brain that controls food intake without causing nausea in an animal model.
Published Big gain in battle against harmful bacteria
(via sciencedaily.com) Original source An unexpected find has enabled important progress to be made in the battle against harmful bacteria.
Published The plague may have caused the downfall of the Stone Age farmers
(via sciencedaily.com) Original source Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe's populations long before the major plague outbreaks of the Middle Ages, new research shows.
Published Tackling the challenge of coca plant ID: Wild vs cultivated for cocaine
(via sciencedaily.com) Original source A new paper reveals that it's not as straightforward as it might seem. Despite decades of data collection by the United Nations Office on Drugs and Crime (UNODC), which has been valuable to monitor changes in areas occupied by illegal coca plantations in South America, there is no reliable scientific method to distinguish between different types of coca plants.
Published Archaeologists report earliest evidence for plant farming in east Africa
(via sciencedaily.com) Original source A trove of ancient plant remains excavated in Kenya helps explain the history of plant farming in equatorial eastern Africa, a region long thought to be important for early farming but where scant evidence from actual physical crops has been previously uncovered.
Published Study examines tree adaptability to climate change
(via sciencedaily.com) Original source Many trees could expand their ranges by more than 25 percent based on their potential temperature tolerances.
Published New one-step method to make multiple edits to a cell's genome
(via sciencedaily.com) Original source A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.
Published First local extinction in the US due to sea level rise, study suggests
(via sciencedaily.com) Original source The United States has lost its only stand of the massive Key Largo tree cactus in what researchers believe is the first local extinction of a species caused by sea level rise in the country.
Published How a plant app helps identify the consequences of climate change
(via sciencedaily.com) Original source A research team has developed an algorithm that analyses observational data from a plant identification app. The novel approach can be used to derive ecological patterns that could provide valuable information about the effects of climate change on plants.
Published Ancient dingo DNA shows modern dingoes share little ancestry with modern dog breeds
(via sciencedaily.com) Original source A study of ancient dingo DNA revealed that the distribution of modern dingoes across Australia, including those on K'gari (formerly Fraser Island), pre-dates European colonization and interventions like the dingo-proof fence.
Published New bio-based tool quickly detects concerning coronavirus variants
(via sciencedaily.com) Original source Researchers have developed a bioelectric device that can detect and classify new variants of coronavirus to identify those that are most harmful. It has the potential to do the same with other viruses, as well.
Published Genomic data integration improves prediction accuracy of apple fruit traits
(via sciencedaily.com) Original source Genotyping techniques can be used to select fruit trees with desired traits at the seedling stage, increasing the efficiency of fruit tree breeding. However, so far, there are multiple different genotyping systems, each generating distinct datasets. In a recent study, Japanese scientists revealed that integrating genomic data obtained with different genotyping systems can effectively combine with historical data, leveraging the accuracy of genomic predictions.