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Categories: Biology: Microbiology, Energy: Alternative Fuels

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Researchers have produced an engineered tissue representing a simplified cerebral cortex by 3D printing human stem cells. When implanted into mouse brain slices, the structures became integrated with the host tissue. The technique may ultimately be developed into tailored repairs to treat brain injuries.

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A new study into sepsis in neonatal babies has uncovered the secrets of the bacteria’s success in causing this life-threatening condition. Using genomic sequencing, they have found how certain strains of bacteria that usually live harmlessly on the skin can evade control measures by colonizing babies’ guts. This will provide new ways to control this threat to babies’ health.

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In a breakthrough for environmentally friendly chemical production, researchers have developed an economical way to make succinic acid, an important industrial chemical, from sugarcane. The team has created a cost-effective, end-to-end pipeline for this valuable organic acid by engineering a tough, acid-tolerant yeast as the fermenting agent, avoiding costly steps in downstream processing. Succinic acid is a widely used additive for food and beverages and has diverse applications in agricultural and pharmaceutical products. This same pipeline can be used to produce other industrially important organic acids from crops rather than petroleum-based processes, significantly reducing greenhouse gas emissions.

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Gut microbes found in wild wolves may be the key to alleviating a debilitating gastrointestinal condition common to domestic dogs.

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Researchers have found that a genetic change that increases the risk of inflammation, through a process described as ‘explosive’ cell death, is carried by up to 3% of the global population.

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Scientists have characterized the genome of a metal-loving bacteria with an affinity for rare earth elements. The research paves the way towards replacing the harsh chemical processing of these elements with a benign practice called biosorption.

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Viruses in soil may not be as destructive to bacteria as once thought and could instead act like lawnmowers, culling older cells and giving space for new growth, according to research.

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An evolutionary gateway which helps pneumonia cells become resistant to antibiotics has been discovered.

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Altered measles and mumps viruses could be used as a platform to create a trivalent COVID-19 vaccine that triggers immunity to multiple variant strains of the SARS-CoV-2 virus, new research in animals suggests.

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Researchers have identified a new enzyme called PUCH, which plays a key role in preventing the spread of parasitic DNA in our genomes. These findings may reveal new insights into how our bodies detect and fight bacteria and viruses to prevent infections.

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Researchers identified and characterized a new cellular compartment in vertebrate cells that might be a precursor of today's eucaryotic nucleus. The study reveals that mammalian cells recognize, cluster, sort and keep extrachromosomal DNA -- like transfected plasmid DNA and endogenous circular DNAs originating from telomeres of the chromosome -- away from chromosomal DNA. That suggests that there is a cell autonomous genome defense system.

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Researchers have developed an improved way to test potential vaccines against bird flu.

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A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders. The tool is an enzyme, AsCas12f, which has been modified to offer the same effectiveness but at one-third the size of the Cas9 enzyme commonly used for gene editing. The compact size means that more of it can be packed into carrier viruses and delivered into living cells, making it more efficient.

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The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis. Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.

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Up to 15 percent of children and five percent of adults are affected by the chronic inflammatory skin disease atopic dermatitis. Despite advanced therapy measures, the severe itching and eczema, especially on the elbows or knees, cause great distress to the patients. Medical researchers have now discovered a new approach: bacteriophages, which colonize the skin as viral components of the microbiome and can drive the development of innovative atopic dermatitis therapies.

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A rare subtype of the world's most common parasite, Blastocystis, has been found to produce a unique by-product of its metabolism, which can cause gut inflammation under normal gut conditions.

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Recent discoveries in the field of epigenetics, the study of inheritance of traits that occur without changing the DNA sequence, have shown that chronological age in mammals correlates with epigenetic changes that accumulate during the lifetime of an individual. In humans, this observation has led to the development of epigenetic clocks, which are now extensively used as biomarkers of aging. While these clocks work accurately from birth until death, they are set back to zero in each new generation. Now, an international team shows that epigenetic clocks not only exist in plants, but that these clocks keep ticking accurately over many generations.

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Scrubbing behind the ears and between the toes may help keep the skin in those regions healthy, new research suggests. The microbiome, or the collection of microbes living on and in the human body, are known to play a role in human health and the skin is no different. A new study has shown that the composition of the skin microbiome varies across dry, moist and oily regions of the skin.

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Researchers have zeroed in on C. auris' uncanny ability to stick to everything from skin to catheters and made a startling discovery: it uses a protein similar to that used by barnacles and mollusks.

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Scientists have identified the source of antibiotic resistance that emerged within bacteria driving the ongoing Yemen cholera epidemic.