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Categories: Biology: Microbiology, Energy: Alternative Fuels

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Researchers have developed a method to use an image generation AI model to create realistic images of single cells, which are then used as 'synthetic data' to train an AI model to better carry out single-cell segmentation.

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Researchers are using artificial intelligence to uncover the link between the gut microbiome and Alzheimer's disease. Previous studies showed that Alzheimer's disease patients have changes in their gut bacteria as the disease develops. The study outlines a computational method to determine how bacterial byproducts called metabolites interact with receptors on cells and contribute to Alzheimer's disease.

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In a scientific breakthrough, researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

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Researchers used structured light and switchable fluorescent molecules to reduce the background light from the out-of-plane regions of microscope samples. This method allowed for the acquisition of images that surpassed the conventional resolution limit, and it may be useful for further study of cell clusters and other biological systems.

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An international team has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle. This is the first time that all the proteins of an organism have been tracked across the cell cycle, which required a combination of deep learning and high-throughput microscopy.

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Some pathogens hide inside human cells to enhance their survival. Researchers have uncovered a unique tactic certain bacteria use to spread in the body without being detected by the immune system. In their study, they reveal the crucial role of a bacterial nanomachine in this infection process.

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Scientists have located and identified alterations in the monkeypox virus genome that potentially correlate with changes in the virus's transmissibility observed in the 2022 outbreak.

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A new DC-DC power converter is superior to previous designs and paves the way for more efficient, reliable and sustainable energy storage and conversion solutions. The development can efficiently interface with a wide range of energy sources while enhancing system stability and simplicity at an unprecedented efficiency.

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Researchers have revealed the regulatory mechanism of a specific protein, TRBP, that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development of antiviral therapies and nucleic acid medicines to treat genetic disorders.

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Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.

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A heart attack will leave a permanent scar on a human heart, yet other animals, including zebrafish, can clear cardiac scar tissue and regrow damaged muscle as adults. Biologists sheds new light on how zebrafish heal heart tissue by comparing how this species responds to heart injury with medaka, a fish species that cannot regenerate cardiac tissue.

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Researchers have identified a potential new treatment for persistent neurological symptoms of Lyme disease, commonly seen even after antibiotic use. The study found that fibroblast growth factor receptor inhibitors, previously studied in cancer, significantly reduced inflammation and cell death in infected brain and nerve tissues.

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The annual influenza vaccine has become less effective on average over time. One reason may be reduced vaccine efficacy in people with obesity than those with a healthier body mass index (BMI), while the number of people with high BMI grows. Findings showed switching mice to a healthy diet four weeks before influenza vaccination protected 100% from a later flu exposure, despite still having a high BMI.

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Animal and plant populations have been extensively studied, which has helped to understand ecosystem processes and evolutionary adaptations. However, this has not been the case with microbial populations due to the impossibility of isolating, culturing and analyzing the genetic content of the different species and their individuals in the laboratory. Therefore, although it is known that populations of microorganisms include a great diversity, this remains largely uncharacterized.

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The origin of life continues to remain a matter of debate. The ribonucleic acid (RNA) world hypothesis proposes that 'ribozymes' which store genetic information and possess catalytic functions may have supported the activities of early life forms. Now, researchers explore how RNA elongation is regulated allosterically, shedding light on its impact on early life processes and offering insights into the fabrication of arbitrary RNA nanostructures with various modern applications.

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Wind power is a source of energy that is both affordable and renewable. However, decision-makers have been reluctant to invest in wind energy due to a perception that wind farms require a lot of land compared to electric power plants driven by fossil fuels. Research was based on the assessment of the land-use of close to 320 wind farms in the U.S. paints a very different picture.

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It's not a single pesticide or virus stressing honey bees, and affecting their health, but exposure to a complex web of multiple interacting stressors encountered while at work pollinating crops, found new research. Scientists have been unable to explain increasing colony mortality, even after decades of research examining the role of specific pesticides, parasitic mites, viruses or genetics. This led the research team to wonder if previous studies were missing something by focusing on one stressor at a time.

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The growing need for antibiotic-free products has challenged producers to decrease or completely stop using antimicrobials as feed supplements in the diet of broiler chickens to improve feed efficiency, growth rate and intestinal health. A research team conducted a study of natural feed additives that are promising alternatives to substitute for antimicrobial growth promoters.

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Researchers have discovered toxic protein particles, shaped like umbrellas, that soil bacteria known as Streptomyces secrete to squelch competitors in their crowded microbial communities, especially others of their own species. What makes these newly detected antibacterial toxins different is that, unlike the Streptomyces' small-molecule antibiotics, umbrella toxins are large complexes composed of multiple proteins. They are also far more specific in the bacteria they target. They tend to go after bacteria that form branching filaments, an usual growth pattern among bacteria. The scientists are intrigued by the potential clinical clinical applications of this discovery, because they suspect the pathogens that cause tuberculosis and diphtheria might be sensitive to umbrella toxins.

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Trying to hit a target size before dividing seems like the best strategy for maintaining a precise cell size, but bacteria don't do that. Now we know why.