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Categories: Biology: Microbiology, Engineering: Biometric
Published Preventing spread of parasitic DNA in our genomes
(via sciencedaily.com) Original source Researchers have identified a new enzyme called PUCH, which plays a key role in preventing the spread of parasitic DNA in our genomes. These findings may reveal new insights into how our bodies detect and fight bacteria and viruses to prevent infections.
Published A hygiene program for chromosomes
(via sciencedaily.com) Original source Researchers identified and characterized a new cellular compartment in vertebrate cells that might be a precursor of today's eucaryotic nucleus. The study reveals that mammalian cells recognize, cluster, sort and keep extrachromosomal DNA -- like transfected plasmid DNA and endogenous circular DNAs originating from telomeres of the chromosome -- away from chromosomal DNA. That suggests that there is a cell autonomous genome defense system.
Published To prepare for next pandemic, researchers tackle bird flu
(via sciencedaily.com) Original source Researchers have developed an improved way to test potential vaccines against bird flu.
Published Small but mighty new gene editor
(via sciencedaily.com) Original source A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders. The tool is an enzyme, AsCas12f, which has been modified to offer the same effectiveness but at one-third the size of the Cas9 enzyme commonly used for gene editing. The compact size means that more of it can be packed into carrier viruses and delivered into living cells, making it more efficient.
Published Allergy study on 'wild' mice challenges the hygiene hypothesis
(via sciencedaily.com) Original source The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis. Now, an article challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice.
Published Atopic dermatitis: Viruses discovered as new therapy option
(via sciencedaily.com) Original source Up to 15 percent of children and five percent of adults are affected by the chronic inflammatory skin disease atopic dermatitis. Despite advanced therapy measures, the severe itching and eczema, especially on the elbows or knees, cause great distress to the patients. Medical researchers have now discovered a new approach: bacteriophages, which colonize the skin as viral components of the microbiome and can drive the development of innovative atopic dermatitis therapies.
Published Gut inflammation caused by substance secreted by microbe
(via sciencedaily.com) Original source A rare subtype of the world's most common parasite, Blastocystis, has been found to produce a unique by-product of its metabolism, which can cause gut inflammation under normal gut conditions.
Published Timing plant evolution with a fast-ticking epigenetic clock
(via sciencedaily.com) Original source Recent discoveries in the field of epigenetics, the study of inheritance of traits that occur without changing the DNA sequence, have shown that chronological age in mammals correlates with epigenetic changes that accumulate during the lifetime of an individual. In humans, this observation has led to the development of epigenetic clocks, which are now extensively used as biomarkers of aging. While these clocks work accurately from birth until death, they are set back to zero in each new generation. Now, an international team shows that epigenetic clocks not only exist in plants, but that these clocks keep ticking accurately over many generations.
Published Skin behind the ears and between the toes can host a collection of unhealthy microbes
(via sciencedaily.com) Original source Scrubbing behind the ears and between the toes may help keep the skin in those regions healthy, new research suggests. The microbiome, or the collection of microbes living on and in the human body, are known to play a role in human health and the skin is no different. A new study has shown that the composition of the skin microbiome varies across dry, moist and oily regions of the skin.
Published Solving a sticky, life-threatening problem
(via sciencedaily.com) Original source Researchers have zeroed in on C. auris' uncanny ability to stick to everything from skin to catheters and made a startling discovery: it uses a protein similar to that used by barnacles and mollusks.
Published Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered
(via sciencedaily.com) Original source Scientists have identified the source of antibiotic resistance that emerged within bacteria driving the ongoing Yemen cholera epidemic.
Published Did animal evolution begin with a predatory lifestyle?
(via sciencedaily.com) Original source Surprising findings on the development of sea anemones suggest that a predatory lifestyle molded their evolution and had a significant impact on the origin of their nervous system. The researchers were able to show that the young life stages (larvae) of the small sea anemone Aiptasia actively feed on living prey and are not dependent on algae. To capture its prey, the anemone larvae use specialized stinging cells and a simple neuronal network.
Published A lethal parasite's secret weapon: Infecting non-immune cells
(via sciencedaily.com) Original source The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.
Published Malaria: Treatment of Plasmodium falciparum malaria patients under threat in the Horn of Africa
(via sciencedaily.com) Original source Diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests and treatment with artemisinin derivatives, the main component of the malaria treatments recommended by the World Health Organization (WHO), are under threat in the Horn of Africa. Scientists have detected the emergence and spread in Eritrea of parasites with both artemisinin resistance and genome modifications that prevent their detection with rapid diagnostic tests, thereby jeopardizing malaria control and elimination campaigns in the region and potentially elsewhere in Africa.
Published Polyps as pixels: Innovative technique maps biochemistry of coral reefs
(via sciencedaily.com) Original source Using an innovative new approach to sampling corals, researchers are now able to create maps of coral biochemistry that reveal with unprecedented detail the distribution of compounds that are integral to the healthy functioning of reefs.
Published An advance in cryo-EM could be a significant boon for research on potential cancer therapies
(via sciencedaily.com) Original source A technology called cryo-electron microscopy enables scientists to see the atomic structure of biological molecules in high resolution. But to date, it has been ineffective for imaging small molecules. A team of biochemists devised a solution that makes it possible to hold small protein molecules in place while they're being imaged, which will enable cryo-EM to produce much clearer images of such molecules. The advance is significant because small and medium-sized protein molecules are an area of focus in research on potential new drugs for cancer and other diseases.
Published Capturing CO2 with electricity: A microbial enzyme inspires electrochemistry
(via sciencedaily.com) Original source Humanity continuously emits greenhouse gases and thereby worsens global warming. Increasing research efforts go into developing strategies to convert these gases, such as carbon dioxide (CO2), into valuable products. CO2 accumulates dramatically over the years and is chemically very stable, thus challenging to transform. Yet, for billions of years, some microbes have actively captured CO2 using highly efficient enzymes. Scientists have now isolated one of these enzymes. When the enzyme was electronically branched on an electrode, they observed the conversion of CO2 to formate with perfect efficiency. This phenomenon will inspire new CO2-fixation systems because of its remarkable directionality and rates.
Published Sperm swimming is caused by the same patterns that are believed to dictate zebra stripes
(via sciencedaily.com) Original source Patterns of chemical interactions are thought to create patterns in nature such as stripes and spots. This new study shows that the mathematical basis of these patterns also governs how sperm tail moves.
Published Tiny CRISPR tool could help shred viruses
(via sciencedaily.com) Original source Scientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy.
Published Novel bacterial proteins from seafloor shine light on climate and astrobiology
(via sciencedaily.com) Original source Researchers have unveiled a remarkable discovery: the identification of novel bacterial proteins that play a vital role in the formation and stability of methane clathrates, which trap gigatons of greenhouse gas beneath the seafloor. These newfound proteins not only suppress methane clathrate growth as effectively as toxic chemicals used in drilling but also prove to be eco-friendly and scalable. This innovative breakthrough not only promises to enhance environmental safety in natural gas transportation but also sheds light on the potential for similar biomolecules to support life beyond Earth.