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Categories: Biology: Microbiology, Engineering: Biometric
Published New, modified CRISPR protein can fit inside virus used for gene therapy
(via sciencedaily.com) Original source Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells.
Published Scientists invent 'living bioelectronics' that can sense and heal skin
(via sciencedaily.com) Original source Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.
Published Novel virus identified in zebrafish from the pet trade causes disease in laboratory fish
(via sciencedaily.com) Original source Zebrafish in the pet trade are asymptomatic carriers of previously undescribed microbes, including a novel virus that causes hemorrhaging in infected laboratory fish, researchers report.
Published Indian Ocean surface temperature could help anticipate dengue outbreaks
(via sciencedaily.com) Original source Although dengue outbreaks cannot be prevented, it is possible to anticipate them. Scientists have recently identified a global climate indicator that may help improve predictions about the magnitude of dengue outbreaks several months in advance. This indicator, which can be used for any world region, is based on temperature fluctuations at the surface of the Indian Ocean. Obtaining reliable long-term predictions could facilitate efforts to tackle this infection, which has been on the rise for several decades and threatens half of the world's population.
Published Antibiotic pollution disrupts the gut microbiome and blocks memory in aquatic snails
(via sciencedaily.com) Original source Antibiotics prevent snails from forming new memories by disrupting their gut microbiome -- the community of beneficial bacteria found in their guts.
Published Researchers expose new symbiosis origin theories, identify experimental systems for plant life
(via sciencedaily.com) Original source Research work on symbiosis -- a mutually beneficial relationship between living organisms -- is pushing back against the newer theory of a 'single-origin' of root nodule symbiosis (RNS) -- that all symbiosis between plant root nodules and nitrogen-fixing bacteria stems from one point--instead suggesting a 'multiple-origin' theory of sybiosis which opens a better understanding for genetically engineering crops.
Published hnRNPM, a guardian of the integrity of cellular protein production
(via sciencedaily.com) Original source Researchers have discovered that the protein hnRNPM prevents the cell from making mistakes while it is producing new proteins, which helps maintain the integrity of this vital process.
Published Editing without 'cutting': Molecular mechanisms of new gene-editing tool revealed
(via sciencedaily.com) Original source New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms contributes greatly to designing gene-editing tools accurate enough for gene therapy treatments.
Published Chicken feathers to deliver chemotherapy drugs and repair enzymes
(via sciencedaily.com) Original source A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
Published New antibiotic kills pathogenic bacteria, spares healthy gut microbes
(via sciencedaily.com) Original source Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.
Published New research approach: Exploring the mouthfeel of food with a microscope
(via sciencedaily.com) Original source A new perspectives article focuses on different ways to study the mouthfeel of food using atomic force microscopy to better understand the biophysical mechanisms that contribute to taste sensations in a broader sense. New findings in this area could drive the development of health-promoting products that contain less salt, fat, sugar and calories but still have a convincing mouthfeel.
Published Orchids support seedlings through 'parental nurture' via shared underground fungal networks
(via sciencedaily.com) Original source Orchid plants nurture their seedlings via an underground fungal network, new research has revealed.
Published Scent detection dogs discern odour molecules better than previously thought
(via sciencedaily.com) Original source According to a recent study, dogs trained to detect scent may be able to identify significantly lower concentrations of odour molecules than has previously been documented.
Published Bird flu: Diverse range of vaccines platforms 'crucial' for enhancing human pandemic preparedness
(via sciencedaily.com) Original source Review of research to-date suggests vaccination remains the most effective strategy for avian influenza prevention and control in humans, despite varying vaccine efficacy across strains.
Published Intermittent fasting shows promise in improving gut health, weight management
(via sciencedaily.com) Original source Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction. The findings could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published Scientists uncover a multibillion-year epic written into the chemistry of life
(via sciencedaily.com) Original source Life evolved from simple geochemical processes present on the early Earth. However, the details of this transformation remain a mystery. In this study, researchers modeled the emergence of metabolic pathways from simple geochemical precursors and concluded that surprisingly few reactions in the history of metabolism may have been lost to time.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Finnish Vole fever spreading further south
(via sciencedaily.com) Original source Researchers have discovered that bank voles in southern Sweden (Sk ne) carry a virus that can cause hemorrhagic fever in humans. This finding was made more than 500 km south of the previously known range. 'We were surprised that such high proportion of the relatively few voles that we caught were actually carrying a hantavirus that makes people ill', says infection disease doctor. The virus strain discovered in Sk ne appears to be more closely related to strains from Finland and Karelia than to the variants found in northern Sweden and Denmark.
Published High H5N1 influenza levels found in mice given raw milk from infected dairy cows
(via sciencedaily.com) Original source Mice administered raw milk samples from dairy cows infected with H5N1 influenza experienced high virus levels in their respiratory organs and lower virus levels in other vital organs, according to new findings. The results suggest that consumption of raw milk by animals poses a risk for H5N1 infection and raises questions about its potential risk in humans.