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Categories: Biology: Microbiology, Environmental: Ecosystems
Published New approach to Epstein-Barr virus and resulting diseases



The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers. Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development



Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Mistaken identity cleared up of foodborne pathogen causing severe symptoms in children



Researchers have developed a quantitative real-time PCR-based detection method for the emerging zoonotic organism Escherichia albertii. They found that E. albertii survives in the human intestinal tract for about four weeks at least.
Published Novel approach to interrogate tissue-specific protein-protein interactions



Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published The global clean water crisis looms large



Water scarcity will intensify with climate and socioeconomic change, disproportionately impacting populations located in the Global South.
Published Tracking down the genetic causes of lupus to personalize treatment



Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.
Published Rising temperatures will significantly reduce streamflow in the upper Colorado river basin as groundwater levels fall



The Colorado River makes life possible in many Western cities and supports agriculture that sustains people throughout the country. Most of the river's water begins as snowmelt from the mountainous watersheds of Colorado, Utah, and Wyoming, and a warming climate will drastically reduce these streamflows, new research finds.
Published Future climate impacts put whale diet at risk



A new study predicts future climate change impacts could disrupt the krill-heavy diet that humpback whales in the southern hemisphere consume.
Published Beach erosion will make Southern California coastal living five times more expensive by 2050, study predicts



Southern California's iconic sandy coastlines are vanishing at an alarming rate, and it's a warning sign for coastal communities worldwide, new research suggests.
Published Exploring diversity in cell division



Animals and fungi predominantly use two different modes of cell division -- called open and closed mitosis, respectively. A new study has shown that different species of Ichthyosporea -- marine protists that are close relatives of both animals and fungi -- use either open and closed mitosis, closely correlated to whether the species has multinucleate life cycle stages. The study demonstrates the way animals do cell division might have evolved long before animals themselves did and how this is linked to an organism's life cycle.
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy



Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published How the 'home' environment influences microbial interactions



A new study shows that real-world ocean conditions make a huge difference in how viral infection affects host bacteria. The findings indicate it is very important to study cells and virocells under nutrient conditions that more closely resemble what they encounter in nature.
Published Smoke covered 70% of California during biggest wildfire years



As much as 70 percent of California was covered by wildfire smoke during parts of 2020 and 2021, according to a new study.
Published Milk samples from the 1940s shed new light on antibiotic resistance



Researchers started with 50 samples collected from 1941 to 1947, and they found that the samples contained seven different Streptococcus species, including two subspecies of S. dysgalactiae. Interestingly, the researchers found some of the samples were resistant to the antibiotic tetracycline and did not carry antibiotic resistance genes typically seen in today's antibiotic-resistant bacterial strains. Since these samples were collected prior to the antibiotic era, the results add to a growing body of literature showing that antibiotic resistance occurred naturally before humans discovered and began to use antibiotics.
Published New insights into the degradation dynamics of organic material in the seafloor



Many processes in the deep sea are not yet well understood, and the role of microbial communities in particular is often a big unknown. This includes, for example, how organic material that sinks from the water surface to the ocean floor is metabolised -- an important building block for a better understanding of the global carbon cycle.
Published Study finds widespread 'cell cannibalism,' related phenomena across tree of life



Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.
Published Conservation of nature's strongholds needed to halt biodiversity loss



To achieve global biodiversity targets, conservationists and governments must prioritize the establishment and effective management of large, interconnected protected areas with high ecological integrity, researchers argue in a new essay.
Published Body lice may be bigger plague spreaders than previously thought



A new laboratory study suggests that human body lice are more efficient at transmitting Yersinia pestis, the bacterium that causes plague, than previously thought, supporting the possibility that they may have contributed to past pandemics.
Published Alaska's rusting waters: Pristine rivers and streams turning orange



Dozens of Alaska's rivers and streams are turning orange. The staining could be the result of minerals exposed by thawing permafrost and climate change, finds a new study.
Published Drug-like inhibitor shows promise in preventing flu



Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.