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Categories: Biology: Microbiology, Environmental: Wildfires

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Scientists have discovered that bacteria can pair up their defense systems to create a formidable force, greater than the sum of its parts, to fight off attack from phage viruses. Understanding how bacteria react to this type of virus is a big step in combating antimicrobial resistance.

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A chemical compound essential to all living things has been synthesized in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life.

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Researchers have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens. Bacteria exposed to higher levels of antibiotics often harbor multiple identical copies of protective antibiotic resistance genes which are linked to 'jumping genes' that can move from strain to strain. Duplicate genes provide a mechanism for resistance to spread and enable evolving resistance to new drugs.

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Forests in the coolest, wettest parts of the western Pacific Northwest are likely to see the biggest increases in burn probability, fire size and number of blazes as the climate continues to get warmer and drier.

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Mice that received fecal implants from donors that had their ovaries removed gained more fat mass and had greater expression of liver genes associated with inflammation, Type 2 diabetes, fatty liver disease and atherosclerosis. The findings may shed light on the greater incidence of metabolic dysfunction in postmenopausal women.

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Researchers have discovered that damage to the cell membrane promotes cellular senescence, or cell aging.

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A professor has demonstrated a connection between viral damage to the gut and premature biological aging.

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About a decade ago, researchers began to observe a recurring challenge in their research: Some of the compounds they were developing to harness energy from bacteria were instead killing the microbes. Not good if the objective of the project was to harness the metabolism of living bacteria to produce electricity.

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To learn about the first organisms on our planet, researchers have to analyze the rocks of the early Earth. These can only be found in a few places on the surface of the Earth. The Pilbara Craton in Western Australia is one of these rare sites: there are rocks there that are around 3.5 billion years old containing traces of the microorganisms that lived at that time. A research team has now found new clues about the formation and composition of this ancient biomass, providing insights into the earliest ecosystems on Earth.

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Scientists discovered antibodies that protect against a host of lethal snake venoms.

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Researchers have discovered that a mutation in the cellulose making machinery of E. coli bacteria allows them to cause severe disease in people -- 'good' bacteria make cellulose and 'bad' bacteria can't. The mutations stopped the E. coli making the cell-surface carbohydrate cellulose and this led to increased inflammation in the intestinal tract of the host, resulting in a breakdown of the intestinal barrier, so the bacteria could spread through the body. Understanding how bacteria spread from intestinal reservoirs to the rest of the body is important in preventing infections and tackling antibiotic resistance.

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The delivery of experimental materials to individual cells with exactness and exclusivity has long been an elusive and much sought-after ability in biology. With it comes the promise of deciphering many longstanding secrets of the cell. A research team has now successfully shown how small molecules and single nanoparticles can be applied directly onto the surface of cells. In the study the scientists describe their technique as a ' kiss' (microkiss) -- an easy and cost-effective new method, unlocking new possibilities in single-cell science with a view towards next generation therapeutic applications.

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Researchers evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples collected from 90 whales and dolphins stranded in Georgia and Florida from 2007 to 2021.

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A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.

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Findings more than a decade in the making reveal a rich diversity of beneficial fungi living in boreal forest trees, with implications for the health of forests.

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Texas A&M researchers combine food-grade wax with essential oils to defend produce from bacteria.

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Mounting evidence suggests that the secret to understanding human health and combating metabolic diseases lies hidden within the microscopic world of our gut bacteria. Recent research reveals that a specific fatty acid produced by gut bacteria directly influences fat metabolism in animals. This research is pivotal as it sheds light on the complex interplay between the diet, gut microbiota, and host metabolic health, offering insights that could open new avenues in our approach to managing metabolic disorders.

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Purple sulfur bacteria (PSB) convert light energy into chemical energy through photosynthesis. Interestingly, certain species can photosynthesize even in environments with low-calcium levels. Using cryo-electron microscopy, researchers unveiled the structure of light-harvesting complexes and elucidated the mechanism that facilitates photosynthesis under low-calcium conditions.

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Researchers found that PD-1-enhanced DNA vaccination can induce sustained virus-specific CD8+ T cell immunity in an AIDS monkey model. The vaccinated monkeys remained free of AIDS for six years and achieved virologic control without the need for combination antiretroviral therapy (cART), a treatment used to suppress viral replication in individuals living with human immunodeficiency virus (HIV). The study also found that polyfunctional and broadly reactive effector-memory virus-specific T cells were maintained in the protected experimental macaques for over six years. The findings provide supporting evidence that the PD-1-enhanced DNA vaccine strategy holds promise as a third-generation DNA vaccine for AIDS prevention and immunotherapy.

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A pharmacy associate professor has developed a novel nanomedicine loaded with genetic material called small interfering RNAs (siRNA) to fight human immunodeficiency virus (HIV) using gene therapy.