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Categories: Biology: Microbiology, Geoscience: Earth Science

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Scientists have amassed genome data for dozens of 'magic mushroom' isolates and cultivars, with the goal to learn more about how their domestication and cultivation has changed them. The findings may point the way to the production of intriguing new cultivars, say the researchers.

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While we often think of diseases as caused by foreign bodies -- bacteria or viruses -- there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team of researchers recently leveraged the power of cutting-edge technology, including an innovative technique called glycoproteomics, to unlock the carbohydrate-based code that governs how certain classes of proteins form themselves into the complex shapes necessary to keep us healthy.

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Researchers have developed a new technique called MAbID. This allows them to simultaneously study different mechanisms of gene regulation, which plays a major role in development and disease. MAbID offers new insights into how these mechanisms work together or against each other.

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New research has revealed a previously unknown process through which pathogens are able to defeat a cell's defense mechanisms with physical force. The discovery represents a potential game-changer in the fight against intracellular pathogens, which cause infectious diseases such as tuberculosis, malaria and chlamydia.

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A simple-to-apply, needle-free vaccine patch is being developed to protect people from the potentially deadly mosquito-borne Zika virus.

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Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical pathway compatible with early Earth conditions, by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding life's origin.

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For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don't hurt.

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Identifying how and why Antarctica's major ice sheets behaved the way they did in the early Miocene could help inform understanding of the sheets' behavior under a warming climate. Together, the ice sheets lock a volume of water equivalent to more than 50 meters of sea level rise and influence ocean currents that affect marine food webs and regional climates. Their fate has profound consequences for life nearly everywhere on Earth.  

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A recent study demonstrates how dripstones can be crucial for reconstructing past climates. The new approach can provide a detailed picture of the climate around early human occupations in South Africa.

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Playing an essential foundational role in an ecosystem, plants contribute to the well-being of human health by helping create resources like food and medicine. Therefore, to better understand how plants can maintain resiliency in the face of challenges like climate change, researchers recently developed an innovative mathematical model that can provide fast and reliable predictions of how far wind can carry a plant's seeds.

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Farmland often harbors a multitude of pathogens which attack plants and reduce yields. A research team has now shown that inoculating the soil with mycorrhizal fungi can help maintain or even improve yields without the use of additional fertilizers or pesticides. In a large-scale field trial, plant yield increased by up to 40 percent.

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A new study tackles the mystery of why bacteria often carry diverse ranges of weapons. The findings show that different weapons are best suited to different competition scenarios. Short-range weapons help bacteria to invade established communities; long-range weapons are useful once established.

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Researchers have discovered that growing bacteria on agar mixed with organs is an efficient and effective way to study infectious pathogens.

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A new bacterial species discovered at the deep-sea hydrothermal vent site 'Crab Spa' provides a deeper understanding of bacterial evolution.

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The San Joaquin Valley in California has experienced vast variability in climate extremes, with droughts and floods that were more severe and lasted longer than what has been seen in the modern record, according to a new study of 600 years of tree rings from the valley.

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The Second Plague Pandemic of the mid-14th century, also known as the Black Death, killed 30-60 percent of the European population and profoundly changed the course of European history. New research suggests that this plague, potentially through resulting changes in diet and hygiene, may also be associated with a shift in the composition of the human oral microbiome toward one that contributes to chronic diseases in modern-day humans.  

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Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

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Fruit and vegetables contain a variety of plant natural products such as flavonoids, which give fruits their colour and are said to have health-promoting properties. Most plant natural products occur in nature as glycosides, i.e. chemical compounds with sugars. In order for humans to absorb the healthy plant natural products, the sugar must be split off in the intestine. Microorganisms in the intestinal flora help to speed up the process. So-called C-glycosides, i.e. plant natural products with a carbon-based bond to a sugar, would even be practically indigestible without the intestinal microbes (e.g. nothofagin in rooibos tea).

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Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.

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A landmark study into the geological timescale distribution of sediment and nutrients over 500 million years shows that species biodiversity on Earth is driven by landscape dynamics.