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Categories: Biology: Microbiology, Geoscience: Earth Science
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published How the 'home' environment influences microbial interactions
(via sciencedaily.com) Original source A new study shows that real-world ocean conditions make a huge difference in how viral infection affects host bacteria. The findings indicate it is very important to study cells and virocells under nutrient conditions that more closely resemble what they encounter in nature.
Published Promethium bound: Rare earth element's secrets exposed
(via sciencedaily.com) Original source Scientists have uncovered the properties of a rare earth element that was first discovered 80 years ago at the very same laboratory, opening a new pathway for the exploration of elements critical in modern technology, from medicine to space travel.
Published Smoke covered 70% of California during biggest wildfire years
(via sciencedaily.com) Original source As much as 70 percent of California was covered by wildfire smoke during parts of 2020 and 2021, according to a new study.
Published Milk samples from the 1940s shed new light on antibiotic resistance
(via sciencedaily.com) Original source Researchers started with 50 samples collected from 1941 to 1947, and they found that the samples contained seven different Streptococcus species, including two subspecies of S. dysgalactiae. Interestingly, the researchers found some of the samples were resistant to the antibiotic tetracycline and did not carry antibiotic resistance genes typically seen in today's antibiotic-resistant bacterial strains. Since these samples were collected prior to the antibiotic era, the results add to a growing body of literature showing that antibiotic resistance occurred naturally before humans discovered and began to use antibiotics.
Published New insights into the degradation dynamics of organic material in the seafloor
(via sciencedaily.com) Original source Many processes in the deep sea are not yet well understood, and the role of microbial communities in particular is often a big unknown. This includes, for example, how organic material that sinks from the water surface to the ocean floor is metabolised -- an important building block for a better understanding of the global carbon cycle.
Published Study finds widespread 'cell cannibalism,' related phenomena across tree of life
(via sciencedaily.com) Original source Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.
Published Conservation of nature's strongholds needed to halt biodiversity loss
(via sciencedaily.com) Original source To achieve global biodiversity targets, conservationists and governments must prioritize the establishment and effective management of large, interconnected protected areas with high ecological integrity, researchers argue in a new essay.
Published Body lice may be bigger plague spreaders than previously thought
(via sciencedaily.com) Original source A new laboratory study suggests that human body lice are more efficient at transmitting Yersinia pestis, the bacterium that causes plague, than previously thought, supporting the possibility that they may have contributed to past pandemics.
Published Alaska's rusting waters: Pristine rivers and streams turning orange
(via sciencedaily.com) Original source Dozens of Alaska's rivers and streams are turning orange. The staining could be the result of minerals exposed by thawing permafrost and climate change, finds a new study.
Published Drug-like inhibitor shows promise in preventing flu
(via sciencedaily.com) Original source Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place? Now, scientists have designed drug-like molecules to do just that, by thwarting the first stage of influenza infection.
Published Regional differences in bird diversity in agroforestry systems
(via sciencedaily.com) Original source The diversity and ecological functionality of bird communities in tropical agroforestry systems are shaped by the surrounding landscape, in particular the extent and composition of the forest.
Published How plants 'mate' for life and repel other suitors
(via sciencedaily.com) Original source Researchers have used a unique microscopic technique to examine the dynamics of pollen tubes in the Arabidopsis plant. They were able to observe the mechanism of one-to-one pollen tube guidance, a process that ensures successful pollination of plants. This process is influenced by multi-step repelling and attracting signals. The results are important for the cultivation of crops, especially under unfavorable environmental conditions.
Published Hope for a cure for visceral leishmaniasis, an often fatal infectious disease
(via sciencedaily.com) Original source Leishmaniasis is a tropical disease affecting a growing number of people worldwide. Each year, between 700,000 and 1 million new cases are reported. Caused by a protozoan parasite of the genus Leishmania, which is transmitted to humans by the simple bite of a sand fly, leishmaniasis comprises three clinical forms, of which the visceral form is the most serious. If left untreated, visceral leishmaniasis, also known as black fever, is almost always fatal.
Published Matcha mouthwash inhibits bacteria that causes periodontitis
(via sciencedaily.com) Original source Matcha, a finely ground green tea powder, may help keep bacteria that causes periodontitis at bay.
Published Researchers find unique adaptations of fungus associated with bee bread
(via sciencedaily.com) Original source The past attempts of honey bee researchers to inventory the fungal diversity in honey bee colonies revealed that Aspergillus flavus is frequently found in hives. In a new study, researchers have discovered that this fungus is uniquely adapted to survive in bee colonies.
Published Rabies outbreaks in Costa Rica cattle linked to deforestation
(via sciencedaily.com) Original source Deforestation in Costa Rica raises the risk of cattle becoming infected with rabies by vampire bats, finds a new study.
Published Studies reveal cell-by-cell changes caused when pig hearts and kidneys are transplanted into humans
(via sciencedaily.com) Original source Two new studies detail the changes seen at the single-cell level in pig organs and recipient human bodies before, during, and just after the xenotransplantation surgeries in the decedents.
Published Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
(via sciencedaily.com) Original source Although periodontitis is an extremely prevalent disorder, it is challenging to conduct detailed and comprehensive analyses of its progression at the cellular level. Recently, researchers developed an improved periodontitis mouse model that simplifies the collection and analysis of multiple periodontal tissue types. Using this model, they clarified the role of an important signaling pathway in the inflammatory response of periodontal tissue, paving the way for better diagnostic and therapeutic strategies for periodontitis.
Published Highly sensitive fiber optic gyroscope senses rotational ground motion around active volcano
(via sciencedaily.com) Original source Researchers have built a prototype fiber optic gyroscope for high resolution, real-time monitoring of ground rotations caused by earthquakes in the active volcanic area of Campi Flegrei in Naples, Italy. A better understanding of the seismic activity in this highly populated area could improve risk assessment and might lead to improved early warning systems.