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Categories: Anthropology: General, Biology: Microbiology

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Researchers have discovered a strong immunological effect of the molecule LecB -- and a way to prevent it.

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New research in mice shows bacteria hijack communication between nerve and immune cells in the meninges -- the protective layers that shield the brain from infection. The experiments detail step by step how bacteria activate pain receptors and initiate a signaling cascade that disables immune cells and culminates in bacterial invasion of the brain. The findings provide much-needed understanding into a critical window during the early stages of bacterial invasion when intervention could halt the spread of infection. The results point to therapeutic pathways for new treatments of bacterial meningitis, an often-fatal disease that can leave survivors with serious neurologic damage.

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A new study reports on genomic data from a 23,000-year-old individual who lived in what was probably the warmest place of Europe at the peak of the last Ice Age. The oldest human genome recovered from the southern tip of Spain adds an important piece of the puzzle to the genetic history of Europe.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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A detailed atlas of gene expression in the zebrafish brain.

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Researchers have identified gut bacteria that are associated with dementia with Lewy bodies. Changing the levels of three bacteria, Collinsella, Ruminococcus, and Bifidobacterium, may delay the onset and progression of this neurodegenerative disease.

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In 2011, scientists recorded a previously unknown feeding strategy in whales around the world. Now, researchers in Australia think they may have found evidence of this behaviour being described in ancient accounts of sea creatures, recorded more than 2,000 years ago. They believe that misunderstandings of these descriptions contributed to myths about medieval sea monsters. Whales are known lunge at their prey when feeding, but recently whales have been spotted at the surface of the water with their jaws open at right angles, waiting for shoals of fish to swim into their mouths. A clip of this strategy was captured in 2021 and went viral on Instagram. This strategy seems to work for the whales because the fish think they have found a place to shelter from predators, not realising they are swimming into danger. It's not known why this strategy has only recently been identified, but scientists speculate that it's a result of changing environmental conditions -- or that whales are being more closely monitored than ever before by drones and other modern technologies.

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Cartilaginous fish have changed much more in the course of their evolutionary history than previously believed. Evidence for this thesis has been provided by new fossils of a ray-like shark, Protospinax annectans, which demonstrate that sharks were already highly evolved in the Late Jurassic.

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A research team has shown that, as early as the first days of infection, HIV is able to create reservoirs where it will hide and persist during antiretroviral therapy.

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By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today -- including plants, animals, and humans.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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Scientists who study the origins and evolution of the plague have examined hundreds of ancient human teeth from Denmark, seeking to address longstanding questions about its arrival, persistence and spread within Scandinavia.

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A team has developed a method for selectively manipulating genetically engineered cells with ultrasound.

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People often associate Escherichia coli with contaminated food, but E. coli has long been a workhorse in biotechnology. Scientists have now demonstrated that the bacterium has further value as part of a system to detect heavy metal contamination in water.

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Researchers have published a method for 3D-printing an ink that contains calcium carbonate-producing bacteria. The 3D-printed mineralized bio-composite is unprecedentedly strong, light, and environmentally friendly, with a range of applications from art to biomedicine.

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It was the height of summer 2022 when the calls started coming in. Scores of dead deer suddenly littered rural properties and park preserves, alarming the public and inconveniencing landowners. According to officials at the Urbana Park District, it was Epizootic Hemorrhagic Disease (EHD), a midge-borne viral illness that pops up in white-tailed deer populations around the state every few years. And when susceptible deer are infected, they die within days. Now, scientists have found gene variants in deer associated with the animals' susceptibility to EHD.

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Fungal pathogens that cause pine ghost canker are infecting conifer trees in urban forests of Southern California, scientists found.

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Scientists recently announced the invention of a nanowire 10,000 times thinner than a human hair that can be cheaply grown by common bacteria and tuned to 'smell' a vast array of chemical tracers -- including those given off by people afflicted with a wide range of medical conditions, such as asthma and kidney disease. Thousands of these specially tuned wires, each sniffing out a different chemical, can be layered onto tiny, wearable sensors, allowing healthcare providers an unprecedented tool for monitoring potential health complications. Since these wires are grown by bacteria, they are organic, biodegradable and far greener than any inorganic nanowire.

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A recent excavation in Megiddo, Israel, unearthed the earliest example of a particular type of cranial surgery in the Ancient Near East -- and potentially one of the oldest examples of leprosy in the world.