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Categories: Anthropology: Early Humans, Biology: Microbiology

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Herpes is not only unpleasant but it can, in some cases, also have dangerous complications and life-threatening consequences. A research team has now introduced a completely new approach for treating herpes. Their method is based on the inhibition of an enzyme that is needed for the release of newly formed virus particles from infected cells.

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Scientists have identified a key part of a mechanism that annotates genetic information before it is passed from fathers to their offspring. The findings shed new light on genomic imprinting, a fundamental, biological process in which a gene from one parent is switched off while the copy from the other parent remains active. Errors in imprinting are linked to a host of diseases, such as the rare disease Silver-Russell syndrome along with certain cancers and diabetes.

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New 'hypervirulent' strains of the bacterium Klebsiella pneumoniae have emerged in healthy people in community settings, prompting a research group to investigate how the human immune system defends against infection. After exposing the strains to components of the human immune system in a laboratory 'test tube' setting, scientists found that some strains were more likely to survive in blood and serum than others, and that neutrophils (white blood cells) are more likely to ingest and kill some strains than others.

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Mold and diseases caused by fungi can greatly impact the shelf life of fruit and vegetables. However, some fungi benefit their hosts by aiding plant survival. Colletotrichum tofieldiae (Ct) is a root mold which typically supports continued plant development even when the plant is starved of phosphorus, an important nutrient for photosynthesis and growth. Researchers studied a unique pathogenic strain of the fungi, called Ct3, which conversely inhibits plant growth.

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Researchers report that the flexible shoulders and elbows that allow us to throw a football or reach a high shelf may have evolved as a natural braking system that let our primate ancestors get out of trees without dying. The researchers used sports-analysis software to compare the climbing movements of chimpanzees and small monkeys called mangabeys. While the animals climb up trees similarly, the researchers found that the shallow, rounded shoulder joints and shortened elbow bones that chimps have -- similar to humans -- allow them to fully extend their arms above their heads when climbing down, holding onto branches like a person going down a ladder to support their greater weight. When early humans left forests for the grassy savanna, these versatile appendages would have been essential for gathering food and using tools for hunting and defense. The findings are among the first to identify the significance of 'downclimbing' in the evolution of apes and early humans.

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Plant-based alternatives such as tempeh and bean burgers provide protein-rich options for those who want to reduce their meat consumption. However, replicating meat's flavors and aromas has proven challenging, with companies often relying on synthetic additives. A recent study unveils a potential solution: onions, chives and leeks that produce natural chemicals akin to the savory scents of meat when fermented with common fungi.

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New research shows that being infected with multiple strains of the Chagas-inducing parasite may hinder the disease's progression.

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Every year, respiratory syncytial viruses (RSV) cause countless respiratory infections worldwide. For infants, young children and people with preexisting conditions, the virus can be life-threatening. The team has explored ways to reduce the risk of infection. Their findings show that -- when used correctly -- alcohol-based hand sanitizers and commercially available surface disinfectants provide good protection against transmission of the virus via surfaces.

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Important progress for RNA research: A team has discovered a new ribozyme that can label RNA molecules in living cells.

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A new study has shown that a subtype of avian flu virus, endemic in poultry farms in China, is undergoing mutational changes, which could increase the risk of the disease being passed on to humans.

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Cancers, degenerative diseases: deregulation of our cells' internal communication pathways is at the root of many conditions. Microtubules -- microscopic protein filaments -- play a crucial role in controlling these exchanges. However, their mechanisms remain poorly understood. A team has identified a new mechanism, involving two proteins, that governs their growth. The discovery opens up unprecedented prospects for the development of new treatments that can act at the very heart of cells.

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A new international study has shown mpox (formerly known as monkeypox) infections to be less severe among those who are vaccinated or had a previous infection in 2022, underlining the importance and effectiveness of vaccination.

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Resistant starch is a nondigestible fiber that ferments in the large intestine, and consumption of it has previously been shown to have a positive effect on metabolism in animal studies. Now, a 4-month randomized controlled trial in people with non-alcoholic fatty liver disease (NAFLD) indicates that daily intake of resistant starch can alter gut bacteria composition and lower liver triglycerides and liver enzymes associated with liver injury and inflammation.

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A 'living material,' made of a natural polymer combined with genetically engineered bacteria, could offer a sustainable and eco-friendly solution to clean pollutants from water. Researchers developed their living material using a seaweed-based polymer and bacteria that have been programmed to produce an enzyme that transforms various organic pollutants into harmless compounds. In tests, heir material decontaminated water solutions tainted with a pollutant from textile manufacturing: indigo carmine, a blue dye that is used to color denim.

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Researchers have discovered some new and surprising ways that viral RNA and influenza virus are detected by human lung cells, which has potential implications for treating people affected by such viruses.

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Researchers have developed an automated version of the viral plaque assay, the gold-standard method for detecting and quantifying viruses.

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Researchers have developed a method for forecasting the short-term progression of an epidemic using extremely limited amounts of data.

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Patulin is a harmful mycotoxin produced by fungi typically found in damaged fruits, including apples, pears, and grapes. In a recent breakthrough, researchers identified a new filamentous fungal strain that can degrade patulin by transforming it into less toxic substances. Their findings provide important insights into the degradation mechanisms for patulin found in nature, and can lead to new ways of controlling patulin toxicity in our food supplies.

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Researchers generated large scale gene expression data to investigate the molecular networks that operate in one of the closest algal relatives of land plants, a humble single-celled alga called Mesotaenium endlicherianum.

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Antibiotic-resistant bacteria get extra nutrients and thrive when the drugs kill 'good' bacteria in the gut, according to new research that could lead to better patient risk assessment and 'microbiome therapeutics' treatments to help combat antibiotic-resistant bacteria.