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Categories: Archaeology: General, Chemistry: Biochemistry

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Antibody drug discovery is an extremely laborious and tedious process. Epitope Binning-seq, a novel method, introduces a groundbreaking approach by enabling simultaneous analysis of multiple antibodies. Using a fluorescently labeled reference antibody (rAb), this method employs flow cytometry to identify similar epitope-binding query antibodies (qAbs). Next-generation sequencing of fluorescence-negative cells then groups qAbs with epitopes akin to the rAb into epitope bins. This innovative technique holds immense potential in enhancing antibody drug discovery process.

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Scientists used CRISPR/Cas9 to increase gene expression in rice by changing its upstream regulatory DNA. While other studies have used the technology to knock out or decrease the expression of genes, this study, is an unbiased gene-editing approach to increase gene expression and downstream photosynthetic activity. The approach is more difficult than transgenic breeding, but could potentially preempt regulatory issues by changing DNA already within the plant, allowing the plants to get in the hands of farmers sooner.

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Ancient apes in Germany co-existed by partitioning resources in their environment, according to a new study.

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New camera chip design allows for optimizing each pixel's timing to maximize signal to noise ratio when tracking real-time visual indicator of neural voltage.

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A research team has developed a liquid metal-based electronic logic device that mimics the intelligent prey-capture mechanism of Venus flytraps. Exhibiting memory and counting properties, the device can intelligently respond to various stimulus sequences without the need for additional electronic components. The intelligent strategies and logic mechanisms in the device provide a fresh perspective on understanding 'intelligence' in nature and offer inspiration for the development of 'embodied intelligence'.

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Little is yet known about the health effects of nanoparticles on pregnancy. An interdisciplinary team is currently analyzing the risks for babies in the womb. Using a lab model, the researchers were able to determine that certain nanoparticles impair the release of chemical messengers in the placenta and thus the formation of blood vessels.

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Advanced technologies enable the controlled release of medicine to specific cells in the body. Scientists argue these same technologies must be applied to agriculture if growers are to meet increasing global food demands.

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Some say the next step in human evolution will be the integration of technology with flesh. Now, researchers have used virtual reality to test whether humans can feel embodiment -- the sense that something is part of one's body -- toward prosthetic 'hands' that resemble a pair of tweezers. They report that participants felt an equal degree of embodiment for the tweezer-hands and were also faster and more accurate in completing motor tasks in virtual reality than when they were equipped with a virtual human hand.

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They bedeviled ancient Greek navies, helped shipwreck Christopher Columbus, aided in the sinking of the Spanish Armada and caused the wharves in San Francisco Bay to collapse into the sea, but until now, scientists have been unable to pinpoint exactly how shipworms -- a family of mollusks -- are able to cause such damage. A team of researchers has discovered that a population of symbiotic microbes, living in an overlooked sub-organ of the gut called the 'typhlosole,' have the ability to secrete the enzymes needed to digest lignin -- the toughest part of wood.

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Bronze cauldrons were used by the inhabitants of the Mongolian steppe around 2,700 years ago to process animal blood and milk. This is shown by a protein analysis of archaeological finds from this period.

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A collaborative team of researchers has made a cracking discovery with the potential to make a significant impact in the sustainable recovery of rare earth elements (REEs), which are in increasing demand for use in green energy technologies. The team found that humble eggshell waste could recover REES from water, offering a new, environmentally friendly method for their extraction.

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A team of researchers has developed a new method for target DNA sequence amplification, testing and analysis.

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Researchers have discovered how networks of neurons in fruit flies transform simple brain signals into coordinated actions. This sheds light on the neural mechanisms underlying complex behaviors for potential application in robotics.

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Engineers have developed a model that combines machine learning and collaborative robotics to accelerate the design of aerogel materials used in wearable heating applications.

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Previous research has demonstrated that adding tin to beta-type titanium alloys improves their strength. But scientists have yet to understand the reasons for this. Now, a research team has pinpointed the exact mechanisms behind this phenomenon.

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Nanoscale electron transfer (ET) in solids is fundamental to the development of multifunctional materials. However, ET in solids is not yet clearly understood. Now, researchers achieved a direct observation of solid-state ET through X-ray crystal analysis by fabricating a novel double-walled non-covalent crystalline nanotube, which can absorb electron donor molecules and maintain its crystalline structure during ET. This innovative approach can lead to the design of novel functional materials soon.

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Researchers uncover how the halogen bond can be exploited to direct sequential dynamics in the multi-functional crystals, offering crucial insights for developing ultrafast-response times for multilevel optical storage.

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A perspective piece describes innovative strategies that significantly reduce both resource consumption and fossil fuel emissions.

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Polarized light waves spin clockwise or counterclockwise as they travel, with one direction behaving differently than the other as it interacts with molecules. This directionality, called chirality or handedness, could provide a way to identify and sort specific molecules for use in biomedicine applications, but researchers have had limited control over the direction of the waves -- until now.

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A new computational machine learning method developed by computational biologists can help researchers discover spatial patterns of gene expression in diseased tissue.